Dual rescue mission: P-G3 dendrimer addresses ovarian and neuroendocrine roots of obesity-linked subfertility.

Nie Y, Kuang Z, Si J, Huang Y, Zeng Y, Shen X, Liu Y, Qiu L, Wang L

Journal of advanced research20 Nov 2025Cited by 1 (Europe PMC)

PMID41274638PMCIDPMC13453890DOI10.1016/j.jare.2025.11.040PepBankPUB-41274638

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-54 (metastin).

01AnimalNot a test of Kisspeptin-54 (metastin) aloneAnimal study (in vivo)Mechanism
In diet-induced obese female mice, P-G3 increased the LH pulse frequency in response to a kisspeptin‑54 challenge at the proestrus stage.
In plain wordsIn obese female mice, P-G3 made the pituitary respond more strongly to kisspeptin‑54, with more frequent LH pulses.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseLH pulse frequency after kisspeptin-54 challenge with P-G3
Study
mousen: not reported in source
diet-induced obese (DIO) female mouse model
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
LH pulse frequency increase
> 60%
proestrus
Source sentences
Summary
At the pituitary, P-G3 enhanced the responsiveness to kisspeptin-54, increasing LH pulse frequency and mean LH level by over 60 % at the proestrus stage.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted a diet-induced obese (DIO) female mouse model to investigate the effect of P-G3.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-4127463801
02AnimalNot a test of Kisspeptin-54 (metastin) aloneAnimal study (in vivo)Mechanism
In diet-induced obese female mice, P-G3 increased the mean LH level in response to a kisspeptin‑54 challenge at the proestrus stage.
In plain wordsIn obese female mice, P-G3 made the pituitary respond more strongly to kisspeptin‑54, with higher average LH.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMean LH level after kisspeptin-54 challenge with P-G3
Study
mousen: not reported in source
diet-induced obese (DIO) female mouse model
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Mean LH increase
> 60%
proestrus
Source sentences
Summary
At the pituitary, P-G3 enhanced the responsiveness to kisspeptin-54, increasing LH pulse frequency and mean LH level by over 60 % at the proestrus stage.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted a diet-induced obese (DIO) female mouse model to investigate the effect of P-G3.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-4127463802

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

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