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Study · Measured the body's own peptide · 2026

6 results

Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome: serum and skeletal muscle profile.

Kutuk IS, Akin S, Demirel H, Mumusoglu S, Ciftci T, Yildiz BO

Journal of endocrinological investigation4 Nov 2025Cited by 1 (Europe PMC)

PMID41186863 (opens in a new tab)DOI10.1007/s40618-025-02747-6 (opens in a new tab)PepBankPUB-41186863
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyEfficacy outcome

    In women with PCOS, serum humanin levels were significantly lower than in healthy controls.

    In plain wordsWomen with PCOS had lower natural humanin levels in their blood than healthy women.

    Peptide
    Humanin
    Outcome
    DecreaseSerum humanin in PCOS versus controls
    Study

    n = 80

    Comparator
    Healthy controls
    Outcome group
    Aging markers · Endocrine and hormones

    Measurements

    Serum humanin median
    474.9 pg/mL
    PCOS
    Serum humanin median
    672.3 pg/mL
    controls

    Source sentences

    Summary
    Serum humanin levels were significantly lower in the PCOS group than those in controls [Median (IQR):474.9 (313.0–633.5) pg/mL vs. 672.3 (481.7-764.6) pg/mL p < 0.001)].
    1 context sentence
    Summary · context
    Forty women with PCOS [(mean ± SD) age:21.8 ± 2.3 years, BMI:25.0 ± 4.8 kg/m2] and 40 age- and BMI-matched healthy controls were included.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In women with PCOS and controls, serum humanin correlated negatively with testosterone.

    In plain wordsWomen with higher natural humanin levels in their blood tended to have lower testosterone.

    Peptide
    Humanin
    Outcome
    DecreaseCorrelation of serum humanin with testosterone
    Study

    n = 80

    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Serum humanin showed negative correlations with testosterone
    1 context sentence
    Summary · context
    Forty women with PCOS [(mean ± SD) age:21.8 ± 2.3 years, BMI:25.0 ± 4.8 kg/m2] and 40 age- and BMI-matched healthy controls were included.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In women with PCOS and controls, serum humanin correlated negatively with 2 h insulin during OGTT.

    In plain wordsWomen with higher natural humanin levels in their blood tended to have lower insulin after a glucose drink.

    Peptide
    Humanin
    Outcome
    DecreaseCorrelation of serum humanin with 2 h insulin during OGTT
    Study

    n = 80

    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Serum humanin showed negative correlations with testosterone, 2 h insulin during OGTT, total cholesterol, LDL, and triglycerides.
    1 context sentence
    Summary · context
    Forty women with PCOS [(mean ± SD) age:21.8 ± 2.3 years, BMI:25.0 ± 4.8 kg/m2] and 40 age- and BMI-matched healthy controls were included.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In women with PCOS and controls, serum humanin correlated negatively with total cholesterol and LDL.

    In plain wordsWomen with higher natural humanin levels in their blood tended to have lower total cholesterol and LDL.

    Peptide
    Humanin
    Outcome
    DecreaseCorrelation of serum humanin with total cholesterol and LDL
    Study

    n = 80

    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Serum humanin showed negative correlations with testosterone, 2 h insulin during OGTT, total cholesterol, LDL, and triglycerides.
    1 context sentence
    Summary · context
    Forty women with PCOS [(mean ± SD) age:21.8 ± 2.3 years, BMI:25.0 ± 4.8 kg/m2] and 40 age- and BMI-matched healthy controls were included.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In women with PCOS and controls, serum humanin correlated negatively with triglycerides.

    In plain wordsWomen with higher natural humanin levels in their blood tended to have lower triglycerides.

    Peptide
    Humanin
    Outcome
    DecreaseCorrelation of serum humanin with triglycerides
    Study

    n = 80

    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Serum humanin showed negative correlations with testosterone, 2 h insulin during OGTT, total cholesterol, LDL, and triglycerides.
    1 context sentence
    Summary · context
    Forty women with PCOS [(mean ± SD) age:21.8 ± 2.3 years, BMI:25.0 ± 4.8 kg/m2] and 40 age- and BMI-matched healthy controls were included.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyEfficacy outcome

    In a subset of women, skeletal muscle humanin levels did not differ significantly between women with PCOS and controls.

    In plain wordsNatural humanin levels in muscle did not differ significantly between women with PCOS and healthy women.

    Peptide
    Humanin
    Outcome
    No significant changeSkeletal muscle humanin in PCOS versus controls
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Western blot analysis showed no significant difference in skeletal muscle humanin levels between PCOS and control groups (p = 0.71).
    2 context sentences
    Summary · context
    Vastus lateralis muscle biopsies were analyzed for humanin expression from a subset of patients and controls who consented to the procedure.
    Summary · context
    Forty women with PCOS [(mean ± SD) age:21.8 ± 2.3 years, BMI:25.0 ± 4.8 kg/m2] and 40 age- and BMI-matched healthy controls were included.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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