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Study · Not a test of the peptide alone · 2026

4 results

Association between blood nicotinamide adenine dinucleotide levels and blood laboratory parameters at baseline and after nicotinamide mononucleotide supplementation in middle-aged healthy individuals: post hoc analysis of a randomized, double-blinded, placebo-controlled clinical trial.

Kuerec AH, Wang W, Fokke KDM, Yi L, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V, Maier AB

GeroScience29 Oct 2025Cited by 1 (Europe PMC)

PMID41162813 (opens in a new tab)PMCIDPMC13355995 (opens in a new tab)DOI10.1007/s11357-025-01968-0 (opens in a new tab)PepBankPUB-41162813
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 01HumanNot a test of NMN (nicotinamide mononucleotide) aloneObservational studyOther

    In healthy middle-aged participants studied during NMN supplementation, increasing NAD was linked to higher hemoglobin.

    In plain wordsIn participants studied during NMN supplementation, increasing NAD was linked to higher hemoglobin.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseHemoglobin association with NAD change
    Study

    n: not reported in source

    Outcome group
    Blood counts and hematopoiesis · Whole body

    Measurements

    Hemoglobin association
    0.027%
    per 1 nM increase in NAD
    95% CI
    0.01 to 0.045%
    Hemoglobin association, per 1 nM increase in NAD

    Source sentences

    Summary
    Every 1 nM increase in the NAD level was associated with an increase in hemoglobin of 0.027% (95% CI: 0.01-0.045)
    1 context sentence
    Summary · context
    To assess associations between blood nicotinamide adenine dinucleotide (NAD) levels and laboratory parameters at baseline and after 60 days of nicotinamide mononucleotide (NMN) supplementation. Post hoc analysis of a randomized, double-blind, clinical trial of daily NMN (300, 600, or 900 mg) or plac…

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  2. 02HumanNot a test of NMN (nicotinamide mononucleotide) aloneObservational studyOther

    In healthy middle-aged participants studied during NMN supplementation, increasing NAD was linked to higher red blood cell counts.

    In plain wordsIn participants studied during NMN supplementation, increasing NAD was linked to higher red blood cell counts.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseRed blood cell association with NAD change
    Study

    n: not reported in source

    Outcome group
    Blood counts and hematopoiesis · Whole body

    Measurements

    Red blood cell association
    0.025%
    per 1 nM increase in NAD
    95% CI
    0.009 to 0.042%
    Red blood cell association, per 1 nM increase in NAD

    Source sentences

    Summary
    red blood cells (RBC) of 0.025% (95% CI: 0.009-0.042)
    2 context sentences
    Summary · context
    NMN-induced increases in blood NAD are associated with an increase in RBC parameters, potentially indicating enhanced oxygen-carrying capacity.
    Summary · context
    To assess associations between blood nicotinamide adenine dinucleotide (NAD) levels and laboratory parameters at baseline and after 60 days of nicotinamide mononucleotide (NMN) supplementation. Post hoc analysis of a randomized, double-blind, clinical trial of daily NMN (300, 600, or 900 mg) or plac…

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  3. 03HumanNot a test of NMN (nicotinamide mononucleotide) aloneObservational studyOther

    In healthy middle-aged participants studied during NMN supplementation, increasing NAD was linked to higher mean corpuscular hemoglobin concentration.

    In plain wordsIn participants studied during NMN supplementation, increasing NAD was linked to higher mean corpuscular hemoglobin concentration.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMean corpuscular hemoglobin concentration association
    Study

    n: not reported in source

    Outcome group
    Blood counts and hematopoiesis · Whole body

    Measurements

    Mean corpuscular hemoglobin concentration association
    0.016 g/dL
    per 1 nM increase in NAD
    95% CI
    0.008 to 0.025 g/dL
    Mean corpuscular hemoglobin concentration association, per 1 nM increase in NAD

    Source sentences

    Summary
    mean corpuscular hemoglobin concentration of 0.016 g/dL (95% CI: 0.008-0.025)
    2 context sentences
    Summary · context
    NMN-induced increases in blood NAD are associated with an increase in RBC parameters, potentially indicating enhanced oxygen-carrying capacity.
    Summary · context
    To assess associations between blood nicotinamide adenine dinucleotide (NAD) levels and laboratory parameters at baseline and after 60 days of nicotinamide mononucleotide (NMN) supplementation. Post hoc analysis of a randomized, double-blind, clinical trial of daily NMN (300, 600, or 900 mg) or plac…

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  4. 04HumanNot a test of NMN (nicotinamide mononucleotide) aloneObservational studyOther

    In healthy middle-aged participants studied during NMN supplementation, increasing NAD was linked to higher uric acid.

    In plain wordsIn participants studied during NMN supplementation, increasing NAD was linked to higher uric acid.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseUric acid association with NAD change
    Study

    n: not reported in source

    Outcome group
    Blood counts and hematopoiesis · Whole body

    Measurements

    Uric acid association
    0.02%
    per 1 nM increase in NAD
    95% CI
    0.003 to 0.038%
    Uric acid association, per 1 nM increase in NAD

    Source sentences

    Summary
    and uric acid of 0.02% (95%CI: 0.003-0.038).
    1 context sentence
    Summary · context
    To assess associations between blood nicotinamide adenine dinucleotide (NAD) levels and laboratory parameters at baseline and after 60 days of nicotinamide mononucleotide (NMN) supplementation. Post hoc analysis of a randomized, double-blind, clinical trial of daily NMN (300, 600, or 900 mg) or plac…

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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