In adults with suboptimal weight loss after metabolic bariatric surgery, daily liraglutide gave more weight loss than placebo at 12 months (between-group difference 7.1 kg).
In plain wordsIn adults who lost too little weight after weight-loss surgery, liraglutide gave more weight loss than placebo after 12 months.
- Peptide
- Liraglutide
- Outcome
- DecreaseWeight loss at 12 months
- Study
n = 48
- Comparator
- Placebo
- Analysis
- Primary
- Outcome group
- Body weight · Metabolic and weight
- Studied dose
- Self-titrated by participants · 12 monthsAs given in this study (human).
Measurements
- weight loss
- 5.7 kg
- liraglutide group
- between-group difference
- 7.1 kg
- liraglutide vs placebo
Source sentences
At 12 months, mean (SE) weight loss in the liraglutide group was 5.7 (1.1) kg with a mean (SD) weight gain of 1.4 (1.2) kg in the placebo group (between-group difference, 7.1 kg [95% CI, 3.9-10.3 kg]; P < .001).
2 context sentences(design, population, supporting numbers)
This prospective, double-blinded, single-center randomized clinical trial compared the effect of daily liraglutide with placebo in adults treated at an academic surgical department.
The study included 24 participants in each arm (liraglutide arm: mean [SD] age, 48.7 [10.5] years; 22 [92%] female; placebo arm: mean [SD] age, 43.6 [11.4] years; 20 [83%] female).