Prostate T2-weighted spin-echo MRI with and without glucagon: a paired scan quality assessment.

Hassanzadeh S, Borisch EA, Froemming AT, Kawashima A, Takahashi N, Riederer SJ

Abdominal radiology (New York)13 Oct 2025Cited by 1 (Europe PMC)

PMID41081882PMCIDPMC13590124DOI10.1007/s00261-025-05215-0PepBankPUB-41081882

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In prostate MRI patients, scans with and without glucagon showed no significant overall differences across all 33 subjects.
In plain wordsIn prostate MRI patients, scan quality did not significantly differ overall between scans with and without glucagon.
Peptide
Glucagon
Outcome
No significant changeOverall prostate MRI scan quality
Study
n = 33
Comparator
Scans without glucagon
Outcome group
Diagnostic imaging quality · Reproductive and sexual health
Studied dose
1 mg · subcutaneousAs given in this study (human).
Source sentences
Summary
Across all 33 subjects, no significant differences were found between glucagon and non-glucagon scans.
2 context sentences(design, population, supporting numbers)
Summary · context
At our institution patients undergoing a clinical prostate MRI exam receive 1 mg of subcutaneous glucagon before scanning.
Summary · context
From February 15, 2024 to February 11, 2025 33 such patients were recruited to undergo an additional, research exam without glucagon.
Report a problemFND-4108188201
02HumanNon-randomized trialEfficacy outcome
In prostate MRI patients with low acquisition-time ratios, glucagon scans improved diagnostic quality versus scans without glucagon (p = 0.048).
In plain wordsIn prostate MRI patients with low scan-time ratios, glucagon improved diagnostic quality compared with scans without glucagon.
Peptide
Glucagon
Outcome
IncreaseDiagnostic quality in low acquisition-time-ratio subgroup
Study
n = 16
Comparator
Scans without glucagon
Outcome group
Diagnostic imaging quality · Reproductive and sexual health
Studied dose
1 mg · subcutaneousAs given in this study (human).
Measurements
P value
0.048
diagnostic quality
Source sentences
Summary
In the low-T_rel group the glucagon scans provided significantly improved diagnostic quality (p = 0.048), PI-QUALv2 sum (p = 0.049), motion scores (p = 0.047), and reader preference (p = 0.042).
3 context sentences(design, population, supporting numbers)
Summary · context
However, the observed negative correlation between glucagon preference and T_rel (p = 0.026) led to stratification into low-T_rel (N = 16) and high-T_rel (N = 17) groups.
Summary · context
At our institution patients undergoing a clinical prostate MRI exam receive 1 mg of subcutaneous glucagon before scanning.
Summary · context
From February 15, 2024 to February 11, 2025 33 such patients were recruited to undergo an additional, research exam without glucagon.
Report a problemFND-4108188203
03HumanNon-randomized trialEfficacy outcome
In prostate MRI patients with low acquisition-time ratios, glucagon improved PI-QUALv2 sum versus scans without glucagon (p = 0.049).
In plain wordsIn prostate MRI patients with low scan-time ratios, glucagon improved PI-QUALv2 scores compared with scans without glucagon.
Peptide
Glucagon
Outcome
IncreasePI-QUALv2 sum in low acquisition-time-ratio subgroup
Study
n = 16
Comparator
Scans without glucagon
Outcome group
Diagnostic imaging quality · Reproductive and sexual health
Studied dose
1 mg · subcutaneousAs given in this study (human).
Measurements
P value
0.049
PI-QUALv2 sum
Source sentences
Summary
In the low-T_rel group the glucagon scans provided significantly improved diagnostic quality (p = 0.048), PI-QUALv2 sum (p = 0.049), motion scores (p = 0.047), and reader preference (p = 0.042).
3 context sentences(design, population, supporting numbers)
Summary · context
However, the observed negative correlation between glucagon preference and T_rel (p = 0.026) led to stratification into low-T_rel (N = 16) and high-T_rel (N = 17) groups.
Summary · context
At our institution patients undergoing a clinical prostate MRI exam receive 1 mg of subcutaneous glucagon before scanning.
Summary · context
From February 15, 2024 to February 11, 2025 33 such patients were recruited to undergo an additional, research exam without glucagon.
Report a problemFND-4108188204
04HumanNon-randomized trialEfficacy outcome
In prostate MRI patients with low acquisition-time ratios, glucagon improved motion scores versus scans without glucagon (p = 0.047).
In plain wordsIn prostate MRI patients with low scan-time ratios, glucagon improved motion scores compared with scans without glucagon.
Peptide
Glucagon
Outcome
IncreaseMotion scores in low acquisition-time-ratio subgroup
Study
n = 16
Comparator
Scans without glucagon
Outcome group
Diagnostic imaging quality · Reproductive and sexual health
Studied dose
1 mg · subcutaneousAs given in this study (human).
Measurements
P value
0.047
motion scores
Source sentences
Summary
In the low-T_rel group the glucagon scans provided significantly improved diagnostic quality (p = 0.048), PI-QUALv2 sum (p = 0.049), motion scores (p = 0.047), and reader preference (p = 0.042).
3 context sentences(design, population, supporting numbers)
Summary · context
However, the observed negative correlation between glucagon preference and T_rel (p = 0.026) led to stratification into low-T_rel (N = 16) and high-T_rel (N = 17) groups.
Summary · context
At our institution patients undergoing a clinical prostate MRI exam receive 1 mg of subcutaneous glucagon before scanning.
Summary · context
From February 15, 2024 to February 11, 2025 33 such patients were recruited to undergo an additional, research exam without glucagon.
Report a problemFND-4108188205
05HumanNon-randomized trialEfficacy outcome
In prostate MRI patients with low acquisition-time ratios, readers preferred glucagon scans over scans without glucagon (p = 0.042).
In plain wordsIn prostate MRI patients with low scan-time ratios, readers preferred glucagon scans over scans without glucagon.
Peptide
Glucagon
Outcome
IncreaseReader preference in low acquisition-time-ratio subgroup
Study
n = 16
Comparator
Scans without glucagon
Outcome group
Diagnostic imaging quality · Reproductive and sexual health
Studied dose
1 mg · subcutaneousAs given in this study (human).
Measurements
P value
0.042
reader preference
Source sentences
Summary
In the low-T_rel group the glucagon scans provided significantly improved diagnostic quality (p = 0.048), PI-QUALv2 sum (p = 0.049), motion scores (p = 0.047), and reader preference (p = 0.042).
3 context sentences(design, population, supporting numbers)
Summary · context
However, the observed negative correlation between glucagon preference and T_rel (p = 0.026) led to stratification into low-T_rel (N = 16) and high-T_rel (N = 17) groups.
Summary · context
At our institution patients undergoing a clinical prostate MRI exam receive 1 mg of subcutaneous glucagon before scanning.
Summary · context
From February 15, 2024 to February 11, 2025 33 such patients were recruited to undergo an additional, research exam without glucagon.
Report a problemFND-4108188206
06HumanObservational studyOther
In prostate MRI patients, preference for glucagon scans correlated negatively with the glucagon-to-non-glucagon acquisition-time ratio (p = 0.026).
In plain wordsIn prostate MRI patients, glucagon scans were linked to lower preference when they took longer relative to scans without glucagon.
Peptide
Glucagon
Outcome
DecreaseGlucagon preference versus acquisition-time ratio
Study
n = 33
Outcome group
Diagnostic imaging quality · Reproductive and sexual health
Studied dose
1 mg · subcutaneousAs given in this study (human).
Measurements
P value
0.026
correlation
Source sentences
Summary
However, the observed negative correlation between glucagon preference and T_rel (p = 0.026) led to stratification into low-T_rel (N = 16) and high-T_rel (N = 17) groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Results were stratified using the acquisition time ratio (T_rel) between the glucagon vs. non-glucagon scans.
Summary · context
At our institution patients undergoing a clinical prostate MRI exam receive 1 mg of subcutaneous glucagon before scanning.
Summary · context
From February 15, 2024 to February 11, 2025 33 such patients were recruited to undergo an additional, research exam without glucagon.
Report a problemFND-4108188202

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

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