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Study · In vitro (cells) · 2025

11 results

Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer.

Shah H, Mohan AM, Buch L, Ramachandran AV, Pandya P

Scientific reports8 Oct 2025Cited by 1 (Europe PMC)

PMID41062590 (opens in a new tab)PMCIDPMC12508150 (opens in a new tab)DOI10.1038/s41598-025-19140-1 (opens in a new tab)PepBankPUB-41062590
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study11

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In triple-negative breast cancer cell lines, kisspeptin‑10 treatment significantly reduced cell viability.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 reduced cell viability.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCell viability
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kp-10 treatment significantly reduced cell viability and migration and induced a dose-dependent upregulation of KISS1 mRNA, suggesting a positive feedback loop.
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In triple-negative breast cancer cell lines, kisspeptin‑10 treatment significantly reduced cell migration.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 reduced cell migration.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCell migration
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kp-10 treatment significantly reduced cell viability and migration and induced a dose-dependent upregulation of KISS1 mRNA, suggesting a positive feedback loop.
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.
  3. 03LabIn vitro (cells)Mechanism

    In triple-negative breast cancer cell lines, kisspeptin‑10 induced a dose-dependent increase in KISS1 mRNA.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 increased KISS1 gene activity in a dose-dependent way.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKISS1 mRNA expression
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kp-10 treatment significantly reduced cell viability and migration and induced a dose-dependent upregulation of KISS1 mRNA, suggesting a positive feedback loop.
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.
  4. 04LabIn vitro (cells)Mechanism

    In triple-negative breast cancer cell lines, kisspeptin‑10 increased the transcription factors GATA2, CDX2 and FLI1.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 increased three gene-control proteins: GATA2, CDX2 and FLI1.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGATA2, CDX2 and FLI1 expression
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kp-10 modulated key transcription factors-upregulating GATA2, CDX2, and FLI1
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.
  5. 05LabIn vitro (cells)Mechanism

    In triple-negative breast cancer cell lines, kisspeptin‑10 decreased the transcription factor ZEB1.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 decreased the gene-control protein ZEB1.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseZEB1 expression
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Alongside this, Kp-10 modulated key transcription factors-upregulating GATA2, CDX2, and FLI1 while downregulating ZEB1-indicating a shift towards a less aggressive transcriptional state.
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.
  6. 06LabIn vitro (cells)Mechanism

    In triple-negative breast cancer cell lines, kisspeptin‑10 treatment increased E-cadherin and beta-catenin, consistent with reversal of epithelial-mesenchymal transition.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 raised E-cadherin and beta-catenin, markers of a less invasive state.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseE-cadherin and beta-catenin levels
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    EMT reversal was evident from increased E-cadherin and β-catenin, and reduced N-cadherin, CD44, and Vimentin.
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.
  7. 07LabIn vitro (cells)Mechanism

    In triple-negative breast cancer cell lines, kisspeptin‑10 treatment reduced N-cadherin, CD44 and Vimentin, consistent with reversal of epithelial-mesenchymal transition.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 lowered N-cadherin, CD44 and Vimentin, markers of an invasive state.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseN-cadherin, CD44 and Vimentin levels
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    EMT reversal was evident from increased E-cadherin and β-catenin, and reduced N-cadherin, CD44, and Vimentin.
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.
  8. 08LabIn vitro (cells)Mechanism

    In triple-negative breast cancer cell lines, kisspeptin‑10 upregulated the pro-apoptotic genes CASP3, CASP8, CASP9 and BAX.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 increased the activity of genes that drive cell death.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePro-apoptotic gene expression (CASP3, CASP8, CASP9, BAX)
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pro-apoptotic genes CASP3, CASP8, CASP9, and BAX were upregulated
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.
  9. 09LabIn vitro (cells)Mechanism

    In triple-negative breast cancer cell lines, kisspeptin‑10 suppressed BCL2.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 lowered BCL2, a gene that protects cells from death.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseBCL2 expression
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BCL2 was suppressed, suggesting activation of both apoptotic pathways.
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.
  10. 10LabIn vitro (cells)Mechanism

    In triple-negative breast cancer cell lines, metabolomics showed changes in pathways related to apoptosis, anti-angiogenesis and redox homeostasis after kisspeptin‑10.

    In plain wordsIn breast cancer cells in the lab, kisspeptin‑10 changed metabolic pathways linked to cell death, blood vessel growth and oxidative balance.

    Peptide
    Kisspeptin-10
    Outcome
    MixedMetabolomic pathways
    Study

    n: not reported in source

    MDA-MB-231 and MDA-MB-468 triple-negative breast cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Metabolomics profile unveiled the changes in pathways related to apoptosis, anti-angiogenesis, and redox homeostasis.
    1 context sentence
    Summary · context
    In this study, we investigated the effect of exogenous Kisspeptin-10 (Kp-10), on MDA-MB-231 and MDA-MB-468 cells.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 11Computer modelEndogenous levelIn silicoOther

    In-silico analyses showed reduced KISS1 expression in metastatic triple-negative breast cancer tissues.

    In plain wordsA computer analysis found less natural KISS1 activity in spreading triple-negative breast cancer tissue.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKISS1 expression in metastatic tumour tissue
    Study

    n: not reported in source

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In silico analyses confirmed reduced KISS1 expression in metastatic TNBC tissues

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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