Skip to content

Study · Animal study (in vivo) · mouse · 2025

5 results

Retatrutide improves steatohepatitis in an accelerated mouse model of diet-induced steatohepatitis with a fructose binge.

Viebahn GK, Khurana A, Freund L, Chilin-Fuentes D, Jepsen K, Rosenthal SB, Chatterjee S, Ellenrieder V, Hsu CL, Schnabl B, Hartmann P

American journal of physiology. Gastrointestinal and liver physiology7 Oct 2025Cited by 3 (Europe PMC)

PMID41056349 (opens in a new tab)PMCIDPMC12643026 (opens in a new tab)DOI10.1152/ajpgi.00164.2025 (opens in a new tab)PepBankPUB-41056349
Source linkPubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with diet-induced steatohepatitis, a 2-week retatrutide intervention significantly reduced body weight compared with vehicle.

    In plain wordsIn female mice with fatty liver disease, 2 weeks of retatrutide lowered body weight compared with vehicle.

    Peptide
    Retatrutide
    Outcome
    DecreaseBody weight
    Study

    mousen: not reported in source

    31-day Western diet, fructose and sucrose model of diet-induced steatohepatitis (C57BL/6N, female)
    Comparator
    Vehicle
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Retatrutide intervention over the final 2 weeks of the 31-day mouse model significantly reduced body weight, ALT levels, hepatic triglycerides and cholesterol, and hepatic inflammatory markers in female mice compared with their vehicle-treated counterparts.
    1 context sentence
    Summary · context
    C57BL/6N mice were subjected to a single fructose binge (10 mg/g body wt), or a new 31-day mouse model of diet-induced steatohepatitis using a Western diet, fructose, and sucrose in the drinking water, and a final fructose binge with or without retatrutide.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with diet-induced steatohepatitis, retatrutide significantly reduced ALT levels compared with vehicle.

    In plain wordsIn female mice with fatty liver disease, retatrutide lowered the liver enzyme ALT compared with vehicle.

    Peptide
    Retatrutide
    Outcome
    DecreaseAlanine aminotransferase (ALT)
    Study

    mousen: not reported in source

    31-day Western diet, fructose and sucrose model of diet-induced steatohepatitis (C57BL/6N, female)
    Comparator
    Vehicle
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Retatrutide intervention over the final 2 weeks of the 31-day mouse model significantly reduced body weight, ALT levels, hepatic triglycerides and cholesterol, and hepatic inflammatory markers in female mice compared with their vehicle-treated counterparts.
    1 context sentence
    Summary · context
    C57BL/6N mice were subjected to a single fructose binge (10 mg/g body wt), or a new 31-day mouse model of diet-induced steatohepatitis using a Western diet, fructose, and sucrose in the drinking water, and a final fructose binge with or without retatrutide.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with diet-induced steatohepatitis, retatrutide significantly reduced hepatic triglycerides compared with vehicle.

    In plain wordsIn female mice with fatty liver disease, retatrutide lowered liver fat (triglycerides) compared with vehicle.

    Peptide
    Retatrutide
    Outcome
    DecreaseHepatic triglycerides
    Study

    mousen: not reported in source

    31-day Western diet, fructose and sucrose model of diet-induced steatohepatitis (C57BL/6N, female)
    Comparator
    Vehicle
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Retatrutide intervention over the final 2 weeks of the 31-day mouse model significantly reduced body weight, ALT levels, hepatic triglycerides and cholesterol, and hepatic inflammatory markers in female mice compared with their vehicle-treated counterparts.
    1 context sentence
    Summary · context
    C57BL/6N mice were subjected to a single fructose binge (10 mg/g body wt), or a new 31-day mouse model of diet-induced steatohepatitis using a Western diet, fructose, and sucrose in the drinking water, and a final fructose binge with or without retatrutide.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with diet-induced steatohepatitis, retatrutide significantly reduced hepatic cholesterol compared with vehicle.

    In plain wordsIn female mice with fatty liver disease, retatrutide lowered liver cholesterol compared with vehicle.

    Peptide
    Retatrutide
    Outcome
    DecreaseHepatic cholesterol
    Study

    mousen: not reported in source

    31-day Western diet, fructose and sucrose model of diet-induced steatohepatitis (C57BL/6N, female)
    Comparator
    Vehicle
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Retatrutide intervention over the final 2 weeks of the 31-day mouse model significantly reduced body weight, ALT levels, hepatic triglycerides and cholesterol, and hepatic inflammatory markers in female mice compared with their vehicle-treated counterparts.
    1 context sentence
    Summary · context
    C57BL/6N mice were subjected to a single fructose binge (10 mg/g body wt), or a new 31-day mouse model of diet-induced steatohepatitis using a Western diet, fructose, and sucrose in the drinking water, and a final fructose binge with or without retatrutide.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with diet-induced steatohepatitis, retatrutide significantly reduced hepatic inflammatory markers compared with vehicle.

    In plain wordsIn female mice with fatty liver disease, retatrutide lowered liver inflammation markers compared with vehicle.

    Peptide
    Retatrutide
    Outcome
    DecreaseHepatic inflammatory markers
    Study

    mousen: not reported in source

    31-day Western diet, fructose and sucrose model of diet-induced steatohepatitis (C57BL/6N, female)
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Liver
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Retatrutide intervention over the final 2 weeks of the 31-day mouse model significantly reduced body weight, ALT levels, hepatic triglycerides and cholesterol, and hepatic inflammatory markers in female mice compared with their vehicle-treated counterparts.
    1 context sentence
    Summary · context
    C57BL/6N mice were subjected to a single fructose binge (10 mg/g body wt), or a new 31-day mouse model of diet-induced steatohepatitis using a Western diet, fructose, and sucrose in the drinking water, and a final fructose binge with or without retatrutide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.