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Study · Animal study (in vivo) · rat · 2025

8 results

Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.

Kern KA, DiBrog AM, Demieri E, Przybysz JT, Clark SD, Mietlicki-Baase EG

Physiology & behavior27 Sept 2025Cited by 1 (Europe PMC)

PMID41022243 (opens in a new tab)PMCIDPMC12614640 (opens in a new tab)DOI10.1016/j.physbeh.2025.115114 (opens in a new tab)PepBankPUB-41022243
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, peripheral pramlintide had no effect on progressive ratio responding for sucrose pellets.

    In plain wordsIn male rats, peripheral pramlintide did not change progressive ratio responding for sucrose pellets.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeProgressive ratio responding for sucrose
    Study

    ratsn: not reported in source

    Male rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rats).

    Source sentences

    Summary
    Results show that peripheral (IP) pramlintide had no effect on progressive ratio responding for sucrose pellets.
    1 context sentence
    Title · context
    Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, central pramlintide reduced active lever pressing for sucrose, even at doses below thresholds for intake and weight effects.

    In plain wordsIn male rats, central pramlintide reduced active lever pressing for sucrose.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseActive lever pressing for sucrose
    Study

    ratsn: not reported in source

    Male rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    In contrast, intracerebroventricular (ICV) pramlintide reduced active lever pressing, reinforcers earned, and breakpoint for sucrose, even at lower doses subthreshold for effects on 24 h chow intake and body weight change.
    1 context sentence
    Title · context
    Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, central pramlintide reduced sucrose reinforcers earned.

    In plain wordsIn male rats, central pramlintide reduced the number of sucrose rewards earned.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseSucrose reinforcers earned
    Study

    ratsn: not reported in source

    Male rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    In contrast, intracerebroventricular (ICV) pramlintide reduced active lever pressing, reinforcers earned, and breakpoint for sucrose, even at lower doses subthreshold for effects on 24 h chow intake and body weight change.
    1 context sentence
    Title · context
    Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, lower central pramlintide doses that reduced sucrose responding were subthreshold for effects on chow intake.

    In plain wordsIn male rats, lower central pramlintide doses that reduced sucrose responding did not affect chow intake.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeChow intake at subthreshold doses
    Study

    ratsn: not reported in source

    Male rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular · 24 hAs given in this study (rats).

    Source sentences

    Summary
    In contrast, intracerebroventricular (ICV) pramlintide reduced active lever pressing, reinforcers earned, and breakpoint for sucrose, even at lower doses subthreshold for effects on 24 h chow intake and body weight change.
    1 context sentence
    Title · context
    Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, lower central pramlintide doses that reduced sucrose responding were subthreshold for effects on body weight change.

    In plain wordsIn male rats, lower central pramlintide doses that reduced sucrose responding did not affect body weight change.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeBody weight change at subthreshold doses
    Study

    ratsn: not reported in source

    Male rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    In contrast, intracerebroventricular (ICV) pramlintide reduced active lever pressing, reinforcers earned, and breakpoint for sucrose, even at lower doses subthreshold for effects on 24 h chow intake and body weight change.
    1 context sentence
    Title · context
    Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, central pramlintide reduced the breakpoint for sucrose.

    In plain wordsIn male rats, central pramlintide reduced the breakpoint for sucrose rewards.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseBreakpoint for sucrose
    Study

    ratsn: not reported in source

    Male rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    In contrast, intracerebroventricular (ICV) pramlintide reduced active lever pressing, reinforcers earned, and breakpoint for sucrose, even at lower doses subthreshold for effects on 24 h chow intake and body weight change.
    1 context sentence
    Title · context
    Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.
  7. 07AnimalAnimal study (in vivo)Safety outcome

    In male rats, central pramlintide completely abolished lever pressing in many animals.

    In plain wordsIn male rats, central pramlintide completely stopped lever pressing in many animals.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseLever pressing abolition
    Study

    ratsn: not reported in source

    Male rats
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    However, lever pressing behavior was completely abolished for many rats, raising concern for unexpected motor effects.
    2 context sentences
    Summary · context
    In contrast, intracerebroventricular (ICV) pramlintide reduced active lever pressing, reinforcers earned, and breakpoint for sucrose, even at lower doses subthreshold for effects on 24 h chow intake and body weight change.
    Title · context
    Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.
  8. 08AnimalAnimal study (in vivo)Safety outcome

    In male rats, central pramlintide significantly reduced distance traveled at several timepoints in an open field test.

    In plain wordsIn male rats, central pramlintide reduced distance traveled during an open field test.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseDistance traveled
    Study

    ratsn: not reported in source

    Male rats
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    To test whether central pramlintide impacted locomotor activity, we conducted an open field study and found that ICV pramlintide significantly reduced distance traveled at several timepoints, suggesting suppressed locomotor activity.
    1 context sentence
    Title · context
    Central pramlintide administration potently suppresses operant responding for sucrose and locomotor activity in male rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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