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Study · Case report or series · n = 2 · 2025

2 results

Lithium Toxicity and Altered Clearance Following Initiation of Semaglutide in Patients With Bipolar Disorder: A Case Series and Literature Review.

Al-Soleiti M, Leung JG, Mubaydeen T, Markota M, Abulseoud O, Singh B, Sola CL

Journal of clinical psychopharmacology26 Sept 2025Cited by 7 (Europe PMC)

PMID40999647 (opens in a new tab)PMCIDPMC12541346 (opens in a new tab)DOI10.1097/jcp.0000000000002090 (opens in a new tab)PepBankPUB-40999647
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanCase report or seriesSafety outcome

    In two patients on stable lithium, starting semaglutide was followed by significantly higher lithium levels and lithium toxicity despite stable renal function.

    In plain wordsIn two people taking lithium, lithium levels rose to toxic levels after semaglutide was started; case reports cannot prove cause.

    Peptide
    Semaglutide
    Outcome
    IncreaseLithium level and toxicity after semaglutide start (2 cases)
    Study

    n = 2

    Outcome group
    Adverse events · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In 2 cases, lithium levels increased significantly, leading to toxicity despite stable renal function and no changes in concurrent medications.
    1 context sentence
    Summary · context
    We present 3 cases involving patients on stable lithium regimens who were initiated on semaglutide, reviewing potential mechanisms underlying the interaction between them.
  2. 02HumanCase report or seriesSafety outcome

    In a third patient, a preemptive lithium dose reduction mitigated toxicity after semaglutide start, although lithium levels stayed higher than anticipated.

    In plain wordsIn one person taking lithium, lowering the lithium dose in advance avoided toxicity after semaglutide was started, though lithium levels still ran higher than expected.

    Peptide
    Semaglutide
    Outcome
    IncreaseLithium level after semaglutide start with preemptive lithium dose reduction (1 case)
    Study

    n = 1

    Outcome group
    Adverse events · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the third case, preemptive reductions in lithium dosage mitigated toxicity, although lithium levels remained higher than anticipated.
    1 context sentence
    Summary · context
    We present 3 cases involving patients on stable lithium regimens who were initiated on semaglutide, reviewing potential mechanisms underlying the interaction between them.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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