Clinical efficacy and influence on the quality of life of children with precocious puberty treated by combination of cluster nursing and triptorelin.

Wang H, Chen J

Medicine1 Sept 2025

PMID40988204PMCIDPMC12459470DOI10.1097/md.0000000000044261PepBankPUB-40988204

Summary

This study evaluates clinical efficacy of cluster nursing plus triptorelin in pediatric precocious puberty and its impact on patient quality of life. A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled. To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics. The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen. The clinical efficacy, growth and development indicators, children's behavioral problems, quality of life, and the occurrence of adverse reactions were observed and compared between the 2 groups. The total effective rate after intervention was significantly higher in the study group (96.36%) than in the control group (85.45%) (P < .05). After intervention, bone age and predicted adult lifetime high level were increased in both groups compared with before intervention, luteinizing hormone and T were decreased compared with before intervention, the study group demonstrated significantly higher predicted adult height versus controls, while bone age, luteinizing hormone, and T levels were significantly lower versus controls (P < .05). Post-intervention depression scores, social withdrawal, hyperactivity and aggression in both groups were lower than before intervention, and the scores of depression, social withdrawal, hyperactivity, and aggression in the study group were lower than those in the control group (P < .05). After intervention, scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, living environment, anxiety experience, and depression experience in both groups were higher than before intervention, and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05). Post-intervention adverse reaction incidence was 3.64% lower in the study group versus controls (10.91%) (P < .05). The combination of cluster nursing and triptorelin therapy can effectively control the growth and development of children with precocious puberty, improve their behavior problems and quality of life. It has high safety and effectiveness and is worthy of popularization and application.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study18

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone18

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, cluster nursing plus triptorelin increased the effective rate versus standard care.
In plain wordsIn children with precocious puberty, cluster nursing plus triptorelin increased the effective rate versus standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseTotal effective rate
Study
n = 110
Comparator
standard care
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Effective rate
96.36%
combined intervention
Effective rate
85.45%
control
Source sentences
Summary
The total effective rate after intervention was significantly higher in the study group (96.36%) than in the control group (85.45%) (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820401
02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, cluster nursing plus triptorelin increased predicted adult height versus standard care.
In plain wordsIn children with precocious puberty, predicted adult height was higher with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePredicted adult height
Study
n = 110
Comparator
standard care
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
the study group demonstrated significantly higher predicted adult height versus controls, while bone age, luteinizing hormone, and T levels were significantly lower versus controls (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820402
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, bone age was lower with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, bone age was lower with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseBone age
Study
n = 110
Comparator
standard care
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
the study group demonstrated significantly higher predicted adult height versus controls, while bone age, luteinizing hormone, and T levels were significantly lower versus controls (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820403
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, LH was lower with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, LH was lower with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLuteinizing hormone
Study
n = 110
Comparator
standard care
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
the study group demonstrated significantly higher predicted adult height versus controls, while bone age, luteinizing hormone, and T levels were significantly lower versus controls (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820404
05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, T levels were lower with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, T levels were lower with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseT levels
Study
n = 110
Comparator
standard care
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
the study group demonstrated significantly higher predicted adult height versus controls, while bone age, luteinizing hormone, and T levels were significantly lower versus controls (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820405
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, depression scores were lower with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, depression scores were lower with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseDepression behavior score
Study
n = 110
Comparator
standard care
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Post-intervention depression scores, social withdrawal, hyperactivity and aggression in both groups were lower than before intervention, and the scores of depression, social withdrawal, hyperactivity, and aggression in the study group were lower than those in the control group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820406
07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, social withdrawal scores were lower with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, social withdrawal scores were lower with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSocial withdrawal
Study
n = 110
Comparator
standard care
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Post-intervention depression scores, social withdrawal, hyperactivity and aggression in both groups were lower than before intervention, and the scores of depression, social withdrawal, hyperactivity, and aggression in the study group were lower than those in the control group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820407
08HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, hyperactivity scores were lower with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, hyperactivity scores were lower with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHyperactivity
Study
n = 110
Comparator
standard care
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Post-intervention depression scores, social withdrawal, hyperactivity and aggression in both groups were lower than before intervention, and the scores of depression, social withdrawal, hyperactivity, and aggression in the study group were lower than those in the control group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820408
09HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, aggression scores were lower with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, aggression scores were lower with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseAggression
Study
n = 110
Comparator
standard care
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Post-intervention depression scores, social withdrawal, hyperactivity and aggression in both groups were lower than before intervention, and the scores of depression, social withdrawal, hyperactivity, and aggression in the study group were lower than those in the control group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820409
10HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, family life scores were higher with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, family life scores were higher with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFamily life quality
Study
n = 110
Comparator
standard care
Outcome group
Quality of life · Whole body
Source sentences
Summary
and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820410
11HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, peer interaction scores were higher with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, peer interaction scores were higher with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePeer interaction quality
Study
n = 110
Comparator
standard care
Outcome group
Quality of life · Whole body
Source sentences
Summary
and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820411
12HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, school life scores were higher with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, school life scores were higher with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseSchool life quality
Study
n = 110
Comparator
standard care
Outcome group
Quality of life · Whole body
Source sentences
Summary
and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820412
13HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, living environment scores were higher with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, living environment scores were higher with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLiving environment quality
Study
n = 110
Comparator
standard care
Outcome group
Quality of life · Whole body
Source sentences
Summary
and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820413
14HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, self-knowledge scores were higher with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, self-knowledge scores were higher with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseSelf-knowledge quality
Study
n = 110
Comparator
standard care
Outcome group
Quality of life · Whole body
Source sentences
Summary
and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820414
15HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, physical emotion scores were higher with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, physical emotion scores were higher with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePhysical emotion quality
Study
n = 110
Comparator
standard care
Outcome group
Quality of life · Whole body
Source sentences
Summary
and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820415
16HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, anxiety quality-of-life scores were higher with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, anxiety quality-of-life scores were higher with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseAnxiety quality-of-life score
Study
n = 110
Comparator
standard care
Outcome group
Quality of life · Mental health and mood
Source sentences
Summary
and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820416
17HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In children with precocious puberty, depression quality-of-life scores were higher with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, depression quality-of-life scores were higher with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseDepression quality-of-life score
Study
n = 110
Comparator
standard care
Outcome group
Quality of life · Mental health and mood
Source sentences
Summary
and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820417
18HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialSafety outcome
In children with precocious puberty, adverse reactions were less frequent with cluster nursing plus triptorelin than with standard care.
In plain wordsIn children with precocious puberty, adverse reactions were less frequent with cluster nursing plus triptorelin than with standard care.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseAdverse reactions
Study
n = 110
Comparator
standard care
Outcome group
Adverse events · Whole body
Measurements
Adverse reaction incidence
3.64%
study group; source wording '3.64% lower in the study group'
Adverse reaction incidence
10.91%
control group
Source sentences
Summary
Post-intervention adverse reaction incidence was 3.64% lower in the study group versus controls (10.91%) (P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled.
Summary · context
To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics.
Summary · context
The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-4098820418

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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