In adults with obesity and no diabetes, semaglutide 7.2 mg reduced bodyweight by 18.7% versus 3.9% with placebo at week 72.
In plain wordsIn adults with obesity, semaglutide 7.2 mg led to much more weight loss than placebo over 72 weeks.
- Peptide
- Semaglutide
- Outcome
- DecreasePercentage change in bodyweight at week 72, 7.2 mg vs placebo
- Study
n = 1,206
- Comparator
- Placebo
- Analysis
- Primary
- Outcome group
- Body weight · Metabolic and weight
- Studied dose
- 7.2 mg once weekly · subcutaneous · 72 weeksAs given in this study (human).
Measurements
- Mean bodyweight change
- −18.7%
- semaglutide 7.2 mg
- Mean bodyweight change
- −3.9%
- placebo
- Estimated treatment difference
- −14.8%
- 7.2 mg vs placebo
Source sentences
and with semaglutide 7·2 mg versus placebo (-18·7% [0·4] vs -3·9% [0·6]; -14·8% [-16·2 to -13·4]; p<0·0001).
2 context sentences(design, population, supporting numbers)
STEP UP was a phase 3b, randomised, double-blind, placebo-controlled and active-controlled trial conducted across 95 hospitals, specialist clinics, and medical centres in 11 countries in adults with BMI 30 kg/m2 or greater, without diabetes.
Participants were randomly assigned (5:1:1) to receive once-weekly subcutaneous semaglutide 7·2 mg, 2·4 mg, or placebo, with a lifestyle intervention, for 72 weeks.