In T2D inadequately controlled with metformin, liraglutide reportedly did not restore the odour-induced POC-sensorimotor-middle temporal circuit after 16 weeks; no significance test or formal drug-superiority contrast was stated.
In plain wordsIn T2D inadequately controlled with metformin, liraglutide reportedly did not restore olfactory-circuit integration after 16 weeks; an exact comparative significance test was unstated.
- Peptide
- Liraglutide
- Outcome
- Direction not reportedOdour-induced functional integration of the POC circuit
- Study
n: not reported in source
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
After 16 weeks, dapagliflozin restored odour-induced functional integration of the POC-sensorimotor cortex-middle temporal cortex circuit (Gaussian random field correction applied), whereas liraglutide and acarbose did not.
3 context sentences(design, population, supporting numbers)
The 16-week randomised, prospective, parallel-group, and open-label trial included 36 patients with T2D inadequately controlled with metformin, who were randomised (1:1:1) to receive dapagliflozin, liraglutide or acarbose.
Meanwhile, 36 healthy controls were recruited.
All participants underwent olfactory task functional magnetic resonance imaging, along with a battery of olfactory and cognitive tests, both at baseline and postintervention.