Kisspeptin-10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway.

Li J, Chen J, Lu L, Gan B

Chemical biology & drug design1 Sept 2025Cited by 1 (Europe PMC)

PMID40944385DOI10.1111/cbdd.70169PepBankPUB-40944385

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with gestational diabetes, kisspeptin‑10 treatment improved fasting blood glucose levels.
In plain wordsIn rats with gestational diabetes, kisspeptin‑10 improved fasting blood sugar.
Peptide
Kisspeptin-10
Outcome
DecreaseFasting blood glucose
Study
ratn: not reported in source
GDM rats (high-fat diet plus streptozotocin)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Kp-10 treatment improved fasting blood glucose (FBG) levels
1 context sentence(design, population, supporting numbers)
Summary · context
We used GDM rat models (induced by a high-fat diet and streptozotocin) and high-glucose-treated HTR8/SVneo trophoblast cells to investigate Kp-10's effects on glucose metabolism, insulin signaling, and the cAMP/PKA pathway.
Report a problemFND-4094438502
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with gestational diabetes, kisspeptin‑10 treatment improved insulin sensitivity.
In plain wordsIn rats with gestational diabetes, kisspeptin‑10 improved insulin sensitivity.
Peptide
Kisspeptin-10
Outcome
IncreaseInsulin sensitivity
Study
ratn: not reported in source
GDM rats (high-fat diet plus streptozotocin)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Kp-10 treatment improved fasting blood glucose (FBG) levels, insulin sensitivity, and fetal outcomes, including increased fetal weight and decreased fetal blood glucose.
1 context sentence(design, population, supporting numbers)
Summary · context
We used GDM rat models (induced by a high-fat diet and streptozotocin) and high-glucose-treated HTR8/SVneo trophoblast cells to investigate Kp-10's effects on glucose metabolism, insulin signaling, and the cAMP/PKA pathway.
Report a problemFND-4094438503
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with gestational diabetes, kisspeptin‑10 treatment increased fetal weight.
In plain wordsIn rats with gestational diabetes, kisspeptin‑10 treatment increased fetal weight.
Peptide
Kisspeptin-10
Outcome
IncreaseFetal weight
Study
ratn: not reported in source
GDM rats (high-fat diet plus streptozotocin)
Outcome group
Body weight · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Kp-10 treatment improved fasting blood glucose (FBG) levels, insulin sensitivity, and fetal outcomes, including increased fetal weight and decreased fetal blood glucose.
1 context sentence(design, population, supporting numbers)
Summary · context
We used GDM rat models (induced by a high-fat diet and streptozotocin) and high-glucose-treated HTR8/SVneo trophoblast cells to investigate Kp-10's effects on glucose metabolism, insulin signaling, and the cAMP/PKA pathway.
Report a problemFND-4094438504
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with gestational diabetes, kisspeptin‑10 treatment decreased fetal blood glucose.
In plain wordsIn rats with gestational diabetes, kisspeptin‑10 treatment lowered fetal blood sugar.
Peptide
Kisspeptin-10
Outcome
DecreaseFetal blood glucose
Study
ratn: not reported in source
GDM rats (high-fat diet plus streptozotocin)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Kp-10 treatment improved fasting blood glucose (FBG) levels, insulin sensitivity, and fetal outcomes, including increased fetal weight and decreased fetal blood glucose.
1 context sentence(design, population, supporting numbers)
Summary · context
We used GDM rat models (induced by a high-fat diet and streptozotocin) and high-glucose-treated HTR8/SVneo trophoblast cells to investigate Kp-10's effects on glucose metabolism, insulin signaling, and the cAMP/PKA pathway.
Report a problemFND-4094438505
05AnimalAnimal study (in vivo)Mechanism
In rats with gestational diabetes, kisspeptin‑10 restored cAMP/PKA signaling in placental tissue.
In plain wordsIn rats with gestational diabetes, kisspeptin‑10 restored a cell-signalling pathway in the placenta.
Peptide
Kisspeptin-10
Outcome
IncreasecAMP/PKA signaling in placental tissue
Study
ratn: not reported in source
GDM rats (high-fat diet plus streptozotocin)
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Moreover, Kp-10 restored the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling pathway
1 context sentence(design, population, supporting numbers)
Summary · context
We used GDM rat models (induced by a high-fat diet and streptozotocin) and high-glucose-treated HTR8/SVneo trophoblast cells to investigate Kp-10's effects on glucose metabolism, insulin signaling, and the cAMP/PKA pathway.
Report a problemFND-4094438506
06AnimalAnimal study (in vivo)Mechanism
In rats with gestational diabetes, kisspeptin‑10 enhanced glucose uptake by upregulating Glut-4, Insr and Irs1 in placental tissue.
In plain wordsIn rats with gestational diabetes, kisspeptin‑10 raised glucose-handling proteins in the placenta.
Peptide
Kisspeptin-10
Outcome
IncreaseGlut-4, Insr and Irs1 expression in placental tissue
Study
ratn: not reported in source
GDM rats (high-fat diet plus streptozotocin)
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
enhanced glucose uptake by upregulating Glut-4, Insr, and Irs1 expression in both placental tissues and HTR8/SVneo cells.
1 context sentence(design, population, supporting numbers)
Summary · context
We used GDM rat models (induced by a high-fat diet and streptozotocin) and high-glucose-treated HTR8/SVneo trophoblast cells to investigate Kp-10's effects on glucose metabolism, insulin signaling, and the cAMP/PKA pathway.
Report a problemFND-4094438507
07AnimalAnimal study (in vivo)Mechanism
The cAMP inhibitor SQ22536 reversed the anti-insulin-resistance effects of kisspeptin‑10, which implicates the cAMP/PKA pathway.
In plain wordsA signalling blocker reversed the effects of kisspeptin‑10, which points to the cAMP/PKA pathway as part of how it works.
Peptide
Kisspeptin-10
Outcome
Not applicableReversal of Kp-10 effects by cAMP inhibitor SQ22536
Study
n: not reported in source
GDM rats or HTR8/SVneo trophoblast cells (not specified in this sentence)
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
The effects of Kp-10 were reversed by the cAMP inhibitor SQ22536, confirming the involvement of the cAMP/PKA pathway in its anti-IR effects.
Report a problemFND-4094438510
08LabIn vitro (cells)Mechanism
In high-glucose-treated HTR8/SVneo trophoblast cells, kisspeptin‑10 restored cAMP/PKA signaling.
In plain wordsIn placental cells in the lab, kisspeptin‑10 restored a cell-signalling pathway.
Peptide
Kisspeptin-10
Outcome
IncreasecAMP/PKA signaling in trophoblast cells
Study
n: not reported in source
High-glucose-treated HTR8/SVneo trophoblast cells
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Moreover, Kp-10 restored the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling pathway and enhanced glucose uptake by upregulating Glut-4, Insr, and Irs1 expression in both placental tissues and HTR8/SVneo cells.
1 context sentence(design, population, supporting numbers)
Summary · context
We used GDM rat models (induced by a high-fat diet and streptozotocin) and high-glucose-treated HTR8/SVneo trophoblast cells to investigate Kp-10's effects on glucose metabolism, insulin signaling, and the cAMP/PKA pathway.
Report a problemFND-4094438508
09LabIn vitro (cells)Mechanism
In high-glucose-treated HTR8/SVneo trophoblast cells, kisspeptin‑10 enhanced glucose uptake by upregulating Glut-4, Insr and Irs1.
In plain wordsIn placental cells in the lab, kisspeptin‑10 increased glucose uptake and raised glucose-handling proteins.
Peptide
Kisspeptin-10
Outcome
IncreaseGlucose uptake and Glut-4, Insr and Irs1 expression in trophoblast cells
Study
n: not reported in source
High-glucose-treated HTR8/SVneo trophoblast cells
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
enhanced glucose uptake by upregulating Glut-4, Insr, and Irs1 expression in both placental tissues and HTR8/SVneo cells.
1 context sentence(design, population, supporting numbers)
Summary · context
We used GDM rat models (induced by a high-fat diet and streptozotocin) and high-glucose-treated HTR8/SVneo trophoblast cells to investigate Kp-10's effects on glucose metabolism, insulin signaling, and the cAMP/PKA pathway.
Report a problemFND-4094438509

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

10AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In rats with gestational diabetes, expression of the Kp-10 receptor Gpr54 was significantly lower in placental tissue and was associated with impaired glucose uptake and insulin resistance.
In plain wordsIn rats with gestational diabetes, the receptor for kisspeptin‑10 was lower in the placenta, along with poorer glucose uptake.
Peptide
Kisspeptin-10
Outcome
Not applicableGpr54 expression in placenta
Study
ratn: not reported in source
GDM rats (high-fat diet plus streptozotocin)
Outcome group
Receptor activity and mechanism · Metabolic and weight
Source sentences
Summary
Our results show that Gpr54 expression was significantly downregulated in the placental tissues of GDM rats, which was associated with impaired glucose uptake and IR.
1 context sentence(design, population, supporting numbers)
Summary · context
We used GDM rat models (induced by a high-fat diet and streptozotocin) and high-glucose-treated HTR8/SVneo trophoblast cells to investigate Kp-10's effects on glucose metabolism, insulin signaling, and the cAMP/PKA pathway.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-4094438501

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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