Skip to content

Study · Animal study (in vivo) · rat · 2025

13 results

[Caffeoylquinic acids from Erigeron breviscapus ameliorates cognitive impairment and mitochondrial dysfunction in AD by activating PINK1/Parkin-mediated mitophagy].

Pu YZ, Chen HF, Wang XY, Su C

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica1 Jul 2025

PMID40904084 (opens in a new tab)DOI10.19540/j.cnki.cjcmm.20250219.402 (opens in a new tab)PepBankPUB-40904084
Publisher pagePubMedAsk about this study
Jump to 13 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In AD rats, NMN significantly improved learning and memory.

    In plain wordsIn rats with Alzheimer disease, NMN improved learning and memory.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedLearning and memory
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In AD rats, the administration of NMN or EBCQA significantly improved learning and memory, restored neuronal morphology in the hippocampus, increased autophagosome numbers, and upregulated the expression of PINK1, Parkin, Beclin 1, and the LC3-Ⅱ/LC3-Ⅰ ratio, while reducing p62 expression.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In AD rats, NMN restored hippocampal neuronal morphology.

    In plain wordsIn rats with Alzheimer disease, NMN restored nerve cell structure in the hippocampus.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedHippocampal neuronal morphology
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In AD rats, the administration of NMN or EBCQA significantly improved learning and memory, restored neuronal morphology in the hippocampus, increased autophagosome numbers, and upregulated the expression of PINK1, Parkin, Beclin 1, and the LC3-Ⅱ/LC3-Ⅰ ratio, while reducing p62 expression.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN increased autophagosome numbers.

    In plain wordsIn rats with Alzheimer disease, NMN increased autophagosome numbers.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAutophagosome number
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In AD rats, the administration of NMN or EBCQA significantly improved learning and memory, restored neuronal morphology in the hippocampus, increased autophagosome numbers, and upregulated the expression of PINK1, Parkin, Beclin 1, and the LC3-Ⅱ/LC3-Ⅰ ratio, while reducing p62 expression.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN increased PINK1 expression.

    In plain wordsIn rats with Alzheimer disease, NMN increased PINK1 expression.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePINK1 expression
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In AD rats, the administration of NMN or EBCQA significantly improved learning and memory, restored neuronal morphology in the hippocampus, increased autophagosome numbers, and upregulated the expression of PINK1, Parkin, Beclin 1, and the LC3-Ⅱ/LC3-Ⅰ ratio, while reducing p62 expression.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN increased Parkin expression.

    In plain wordsIn rats with Alzheimer disease, NMN increased Parkin expression.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseParkin expression
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In AD rats, the administration of NMN or EBCQA significantly improved learning and memory, restored neuronal morphology in the hippocampus, increased autophagosome numbers, and upregulated the expression of PINK1, Parkin, Beclin 1, and the LC3-Ⅱ/LC3-Ⅰ ratio, while reducing p62 expression.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN increased Beclin 1 expression.

    In plain wordsIn rats with Alzheimer disease, NMN increased Beclin 1 expression.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBeclin 1 expression
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In AD rats, the administration of NMN or EBCQA significantly improved learning and memory, restored neuronal morphology in the hippocampus, increased autophagosome numbers, and upregulated the expression of PINK1, Parkin, Beclin 1, and the LC3-Ⅱ/LC3-Ⅰ ratio, while reducing p62 expression.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN increased the LC3-Ⅱ/LC3-Ⅰ ratio.

    In plain wordsIn rats with Alzheimer disease, NMN increased the LC3-Ⅱ/LC3-Ⅰ ratio.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseLC3-II/LC3-I ratio
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In AD rats, the administration of NMN or EBCQA significantly improved learning and memory, restored neuronal morphology in the hippocampus, increased autophagosome numbers, and upregulated the expression of PINK1, Parkin, Beclin 1, and the LC3-Ⅱ/LC3-Ⅰ ratio, while reducing p62 expression.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN reduced p62 expression.

    In plain wordsIn rats with Alzheimer disease, NMN reduced p62 expression.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Decreasep62 expression
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In AD rats, the administration of NMN or EBCQA significantly improved learning and memory, restored neuronal morphology in the hippocampus, increased autophagosome numbers, and upregulated the expression of PINK1, Parkin, Beclin 1, and the LC3-Ⅱ/LC3-Ⅰ ratio, while reducing p62 expression.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN elevated hippocampal ATP content.

    In plain wordsIn rats with Alzheimer disease, NMN increased hippocampal ATP.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseHippocampal ATP
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, the treatment with NMN or EBCQA both elevated ATP content, mitochondrial respiratory chain complex Ⅰ, Ⅲ, and Ⅳ activities, and mitochondrial membrane potential in the hippocampus.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN elevated hippocampal mitochondrial respiratory chain complex Ⅰ activity.

    In plain wordsIn rats with Alzheimer disease, NMN increased hippocampal mitochondrial complex Ⅰ activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseComplex I activity
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, the treatment with NMN or EBCQA both elevated ATP content, mitochondrial respiratory chain complex Ⅰ, Ⅲ, and Ⅳ activities, and mitochondrial membrane potential in the hippocampus.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN elevated hippocampal mitochondrial respiratory chain complex Ⅲ activity.

    In plain wordsIn rats with Alzheimer disease, NMN increased hippocampal mitochondrial complex Ⅲ activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseComplex III activity
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, the treatment with NMN or EBCQA both elevated ATP content, mitochondrial respiratory chain complex Ⅰ, Ⅲ, and Ⅳ activities, and mitochondrial membrane potential in the hippocampus.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN elevated hippocampal mitochondrial respiratory chain complex Ⅳ activity.

    In plain wordsIn rats with Alzheimer disease, NMN increased hippocampal mitochondrial complex Ⅳ activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseComplex IV activity
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, the treatment with NMN or EBCQA both elevated ATP content, mitochondrial respiratory chain complex Ⅰ, Ⅲ, and Ⅳ activities, and mitochondrial membrane potential in the hippocampus.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In AD rats, NMN elevated hippocampal mitochondrial membrane potential.

    In plain wordsIn rats with Alzheimer disease, NMN increased hippocampal mitochondrial membrane potential.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    ratn: not reported in source

    Alzheimer disease rat model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, the treatment with NMN or EBCQA both elevated ATP content, mitochondrial respiratory chain complex Ⅰ, Ⅲ, and Ⅳ activities, and mitochondrial membrane potential in the hippocampus.
    1 context sentence
    Summary · context
    An AD rat model was established through intraperitoneal injection of D-galactose and intragastric administration of aluminum trichloride.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.