Semaglutide Overdose in a Diabetic Patient: Suicidal Behavior and Multiorgan Failure.

Zamir D, Ovadia YS, Ben-Bassat O, Zamir M, Malnick SDH

The American journal of case reports24 Aug 2025Cited by 1 (Europe PMC)

PMID40849680PMCIDPMC12396086DOI10.12659/ajcr.947682PepBankPUB-40849680

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanCase report or seriesSafety outcome
In a 67-year-old man with diabetes, a self-injected semaglutide overdose was followed by multiorgan failure.
In plain wordsA 67-year-old man with diabetes who injected a month of semaglutide at once was admitted with failure of several organs.
Peptide
Semaglutide
Outcome
IncreaseMultiorgan failure after overdose
Study
n = 1
Outcome group
Adverse events · Whole body
Studied dose
weekly 1-mg regimen; monthly prescription injected at once, 4 times the permitted dose · self-injectionAs given in this study (human).
Source sentences
Summary
He presented with multiorgan failure, hypoglycemia, cholestatic liver dysfunction, and 2 duodenal ulcers, and reported weakness, appetite loss, epigastric pain, severe diarrhea, and melena over 2 weeks, and syncope the day before admission.
2 context sentences(design, population, supporting numbers)
Summary · context
CASE REPORT We describe a rare case of suicide-related behavior, adverse outcomes, and a self-injected Semaglutide overdose in a 67-year-old man with diabetes mellitus and overweight.
Summary · context
In further questioning, the patient recalled feeling moody and injecting his monthly Semaglutide prescription all at 1 time, 14 days before admission.
Report a problemFND-4084968001
02HumanCase report or seriesSafety outcome
In the same patient, the semaglutide overdose was followed by hypoglycemia.
In plain wordsAfter injecting a month of semaglutide at once, this man had low blood sugar.
Peptide
Semaglutide
Outcome
IncreaseHypoglycemia after overdose
Study
n = 1
Outcome group
Adverse events · Metabolic and weight
Studied dose
weekly 1-mg regimen; monthly prescription injected at once, 4 times the permitted dose · self-injectionAs given in this study (human).
Source sentences
Summary
He presented with multiorgan failure, hypoglycemia, cholestatic liver dysfunction, and 2 duodenal ulcers, and reported weakness, appetite loss, epigastric pain, severe diarrhea, and melena over 2 weeks, and syncope the day before admission.
2 context sentences(design, population, supporting numbers)
Summary · context
CASE REPORT We describe a rare case of suicide-related behavior, adverse outcomes, and a self-injected Semaglutide overdose in a 67-year-old man with diabetes mellitus and overweight.
Summary · context
In further questioning, the patient recalled feeling moody and injecting his monthly Semaglutide prescription all at 1 time, 14 days before admission.
Report a problemFND-4084968002
03HumanCase report or seriesSafety outcome
In the same patient, the semaglutide overdose was followed by cholestatic liver dysfunction.
In plain wordsAfter injecting a month of semaglutide at once, this man had a liver problem that slows bile flow.
Peptide
Semaglutide
Outcome
IncreaseCholestatic liver dysfunction after overdose
Study
n = 1
Outcome group
Adverse events · Liver
Studied dose
weekly 1-mg regimen; monthly prescription injected at once, 4 times the permitted dose · self-injectionAs given in this study (human).
Source sentences
Summary
cholestatic liver dysfunction, and 2 duodenal ulcers, and reported weakness, appetite loss, epigastric pain, severe diarrhea, and melena over 2 weeks, and syncope the day before admission.
2 context sentences(design, population, supporting numbers)
Summary · context
CASE REPORT We describe a rare case of suicide-related behavior, adverse outcomes, and a self-injected Semaglutide overdose in a 67-year-old man with diabetes mellitus and overweight.
Summary · context
In further questioning, the patient recalled feeling moody and injecting his monthly Semaglutide prescription all at 1 time, 14 days before admission.
Report a problemFND-4084968003
04HumanCase report or seriesSafety outcome
In the same patient, the semaglutide overdose was followed by 2 duodenal ulcers, which improved by discharge.
In plain wordsAfter injecting a month of semaglutide at once, this man had two ulcers in the upper gut, which improved by discharge.
Peptide
Semaglutide
Outcome
IncreaseDuodenal ulcers after overdose
Study
n = 1
Outcome group
Adverse events · Gastrointestinal
Studied dose
weekly 1-mg regimen; monthly prescription injected at once, 4 times the permitted dose · self-injectionAs given in this study (human).
Source sentences
Summary
and 2 duodenal ulcers, and reported weakness, appetite loss, epigastric pain, severe diarrhea, and melena over 2 weeks, and syncope the day before admission.
2 context sentences(design, population, supporting numbers)
Summary · context
His clinical status improved gradually, including duodenal ulcers upon discharge.
Summary · context
CASE REPORT We describe a rare case of suicide-related behavior, adverse outcomes, and a self-injected Semaglutide overdose in a 67-year-old man with diabetes mellitus and overweight.
Report a problemFND-4084968004
05HumanCase report or seriesSafety outcome
In the same patient, the overdose was followed over 2 weeks by appetite loss, epigastric pain, severe diarrhea and melena.
In plain wordsAfter injecting a month of semaglutide at once, this man had two weeks of appetite loss, stomach pain, severe diarrhea and black stools.
Peptide
Semaglutide
Outcome
IncreaseGastrointestinal symptoms after overdose (appetite loss, epigastric pain, severe diarrhea, melena)
Study
n = 1
Outcome group
Adverse events · Gastrointestinal
Studied dose
weekly 1-mg regimen; monthly prescription injected at once, 4 times the permitted dose · self-injectionAs given in this study (human).
Source sentences
Summary
reported weakness, appetite loss, epigastric pain, severe diarrhea, and melena over 2 weeks
2 context sentences(design, population, supporting numbers)
Summary · context
CASE REPORT We describe a rare case of suicide-related behavior, adverse outcomes, and a self-injected Semaglutide overdose in a 67-year-old man with diabetes mellitus and overweight.
Summary · context
In further questioning, the patient recalled feeling moody and injecting his monthly Semaglutide prescription all at 1 time, 14 days before admission.
Report a problemFND-4084968005
06HumanCase report or seriesSafety outcome
In the same patient, weakness and, the day before admission, syncope were reported after the semaglutide overdose.
In plain wordsAfter injecting a month of semaglutide at once, this man reported weakness and fainted the day before he went to hospital.
Peptide
Semaglutide
Outcome
IncreaseWeakness and syncope around overdose
Study
n = 1
Outcome group
Adverse events · Whole body
Studied dose
weekly 1-mg regimen; monthly prescription injected at once, 4 times the permitted dose · self-injectionAs given in this study (human).
Source sentences
Summary
He presented with multiorgan failure, hypoglycemia, cholestatic liver dysfunction, and 2 duodenal ulcers, and reported weakness, appetite loss, epigastric pain, severe diarrhea, and melena over 2 weeks, and syncope the day before admission.
Report a problemFND-4084968006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:04 UTC
Study results updated
Version 1
9 Oct 2026, 03:06 UTC
First added · source update from Europe PMC

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