Skip to content

Study · Animal study (in vivo) · mouse · 2025

13 results

Nicotinamide mononucleotide protects ovarian function and oocyte developmental competence during chemotherapy.

Shen L, Li H, Gong X, Zhang H, Zhao Y

Journal of ovarian research23 Aug 2025Cited by 2 (Europe PMC)

PMID40849491 (opens in a new tab)PMCIDPMC12374331 (opens in a new tab)DOI10.1186/s13048-025-01782-4 (opens in a new tab)PepBankPUB-40849491
Read at sourcePubMedAsk about this study
Jump to 13 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In CTX-treated mice, NMN increased ovarian NAD+ content.

    In plain wordsIn mice receiving CTX, NMN increased ovarian NAD+ compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOvarian NAD+
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation during CTX treatment increased NAD+ content in the ovary, improved ovarian reserve, enhanced endocrine function, reduced reactive oxygen species (ROS) levels, alleviated DNA damage, and reduced apoptosis.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In CTX-treated mice, NMN improved ovarian reserve.

    In plain wordsIn mice receiving CTX, NMN improved ovarian reserve compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedOvarian reserve
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation during CTX treatment increased NAD+ content in the ovary, improved ovarian reserve, enhanced endocrine function, reduced reactive oxygen species (ROS) levels, alleviated DNA damage, and reduced apoptosis.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In CTX-treated mice, NMN enhanced endocrine function.

    In plain wordsIn mice receiving CTX, NMN improved hormone function compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedEndocrine function
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation during CTX treatment increased NAD+ content in the ovary, improved ovarian reserve, enhanced endocrine function, reduced reactive oxygen species (ROS) levels, alleviated DNA damage, and reduced apoptosis.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In CTX-treated mice, NMN reduced ovarian ROS.

    In plain wordsIn mice receiving CTX, NMN reduced ovarian reactive oxygen species compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOvarian ROS
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation during CTX treatment increased NAD+ content in the ovary, improved ovarian reserve, enhanced endocrine function, reduced reactive oxygen species (ROS) levels, alleviated DNA damage, and reduced apoptosis.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In CTX-treated mice, NMN alleviated ovarian DNA damage.

    In plain wordsIn mice receiving CTX, NMN reduced ovarian DNA damage compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOvarian DNA damage
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation during CTX treatment increased NAD+ content in the ovary, improved ovarian reserve, enhanced endocrine function, reduced reactive oxygen species (ROS) levels, alleviated DNA damage, and reduced apoptosis.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In CTX-treated mice, NMN reduced ovarian apoptosis.

    In plain wordsIn mice receiving CTX, NMN reduced ovarian cell death compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOvarian apoptosis
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation during CTX treatment increased NAD+ content in the ovary, improved ovarian reserve, enhanced endocrine function, reduced reactive oxygen species (ROS) levels, alleviated DNA damage, and reduced apoptosis.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In CTX-treated mice, NMN improved two-cell embryo formation rates.

    In plain wordsIn mice receiving CTX, NMN increased two-cell embryo formation compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseTwo-cell embryo formation
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, this supplementation improved the rates of two-cell embryo and blastocyst formation, increased total cell counts, while decreasing ROS levels, DNA damage, and apoptosis in blastocysts.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In CTX-treated mice, NMN improved blastocyst formation rates.

    In plain wordsIn mice receiving CTX, NMN increased blastocyst formation compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBlastocyst formation
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, this supplementation improved the rates of two-cell embryo and blastocyst formation, increased total cell counts, while decreasing ROS levels, DNA damage, and apoptosis in blastocysts.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In CTX-treated mice, NMN increased blastocyst total cell counts.

    In plain wordsIn mice receiving CTX, NMN increased blastocyst cell counts compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBlastocyst cell count
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, this supplementation improved the rates of two-cell embryo and blastocyst formation, increased total cell counts, while decreasing ROS levels, DNA damage, and apoptosis in blastocysts.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In CTX-treated mice, NMN reduced blastocyst ROS levels.

    In plain wordsIn mice receiving CTX, NMN reduced blastocyst reactive oxygen species compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBlastocyst ROS
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, this supplementation improved the rates of two-cell embryo and blastocyst formation, increased total cell counts, while decreasing ROS levels, DNA damage, and apoptosis in blastocysts.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In CTX-treated mice, NMN reduced blastocyst DNA damage.

    In plain wordsIn mice receiving CTX, NMN reduced blastocyst DNA damage compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBlastocyst DNA damage
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, this supplementation improved the rates of two-cell embryo and blastocyst formation, increased total cell counts, while decreasing ROS levels, DNA damage, and apoptosis in blastocysts.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In CTX-treated mice, NMN reduced blastocyst apoptosis.

    In plain wordsIn mice receiving CTX, NMN reduced blastocyst cell death compared with CTX alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBlastocyst apoptosis
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, this supplementation improved the rates of two-cell embryo and blastocyst formation, increased total cell counts, while decreasing ROS levels, DNA damage, and apoptosis in blastocysts.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In CTX-treated mice, NMN protection may involve ovarian Banp and Rbm47 and oocyte Sgk1.

    In plain wordsIn mice receiving CTX, NMN protection may involve Banp, Rbm47, and Sgk1 genes.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedCandidate protective genes
    Study

    mousen: not reported in source

    CTX-treated female C57 mice
    Comparator
    CTX
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, the protective mechanisms of NMN may involve key genes such as Banp and Rbm47 in the ovarian tissue, along with serum/glucocorticoid-regulated kinase 1 (Sgk1) in oocytes.
    1 context sentence
    Summary · context
    Eight-week-old female C57 mice were underwent to a 14-day treatment protocol, receiving either saline, CTX, or CTX combined with NMN supplementation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.