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Study · Animal study (in vivo) · mouse · 2025

4 results

Administration of β-Nicotinamide Mononucleotide Attenuates Myocardial Dysfunction in Tail-Suspended Mice.

Gu W, Liu D, Wei L, Yang Z, Jiang S, Dai S, Cao T, Shen Z

Journal of cardiovascular pharmacology and therapeutics1 Jan 2025Cited by 2 (Europe PMC)

PMID40820325 (opens in a new tab)DOI10.1177/10742484251369609 (opens in a new tab)PepBankPUB-40820325
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In tail-suspended mice, NMN attenuated myocardial atrophy.

    In plain wordsIn mice with simulated microgravity, NMN reduced heart muscle atrophy.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMyocardial atrophy
    Study

    mousen: not reported in source

    tail-suspended C57BL/6 mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 mg/kg every other dayAs given in this study (mouse).

    Source sentences

    Summary
    Administration of NMN attenuates myocardial atrophy and preserves myocardial function in tail-suspended mice.
    2 context sentences
    Summary · context
    Simulated microgravity was induced by tail-suspension in C57BL/6 mice for 28 days.
    Summary · context
    NMN (100 mg/kg body weight) was given every other day after the onset of tail-suspension.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In tail-suspended mice, NMN preserved myocardial function.

    In plain wordsIn mice with simulated microgravity, NMN preserved heart function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedMyocardial function
    Study

    mousen: not reported in source

    tail-suspended C57BL/6 mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 mg/kg every other dayAs given in this study (mouse).

    Source sentences

    Summary
    Administration of NMN attenuates myocardial atrophy and preserves myocardial function in tail-suspended mice.
    2 context sentences
    Summary · context
    Simulated microgravity was induced by tail-suspension in C57BL/6 mice for 28 days.
    Summary · context
    NMN (100 mg/kg body weight) was given every other day after the onset of tail-suspension.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In tail-suspended mice, NMN cardioprotection was associated with reduced oxidative stress.

    In plain wordsIn mice with simulated microgravity, NMN heart protection was linked to reduced oxidative stress.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOxidative stress
    Study

    mousen: not reported in source

    tail-suspended C57BL/6 mice
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    100 mg/kg every other dayAs given in this study (mouse).

    Source sentences

    Summary
    These cardioprotective effects of NAD+ repletion were associated with the reduction of oxidative stress and improvement of autophagic flux.
    2 context sentences
    Summary · context
    Simulated microgravity was induced by tail-suspension in C57BL/6 mice for 28 days.
    Summary · context
    NMN (100 mg/kg body weight) was given every other day after the onset of tail-suspension.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In tail-suspended mice, NMN cardioprotection was associated with improved autophagic flux.

    In plain wordsIn mice with simulated microgravity, NMN heart protection was linked to improved cellular recycling.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedAutophagic flux
    Study

    mousen: not reported in source

    tail-suspended C57BL/6 mice
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    100 mg/kg every other dayAs given in this study (mouse).

    Source sentences

    Summary
    These cardioprotective effects of NAD+ repletion were associated with the reduction of oxidative stress and improvement of autophagic flux.
    2 context sentences
    Summary · context
    Simulated microgravity was induced by tail-suspension in C57BL/6 mice for 28 days.
    Summary · context
    NMN (100 mg/kg body weight) was given every other day after the onset of tail-suspension.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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