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Study · Animal study (in vivo) · dog · 2026

5 results

Effect of kisspeptin with or without cabergoline on the estrus cycle and reproductive hormones in female dogs.

Bozkurt G, Agaoglu AR, Aslan S, Wehrend A, Cortu A, Tepik FZ, Schäfer-Somi S

Theriogenology11 Aug 2025Cited by 1 (Europe PMC)

PMID40816115 (opens in a new tab)DOI10.1016/j.theriogenology.2025.117633 (opens in a new tab)PepBankPUB-40816115
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anestrus female dogs, KP-10 given alone increased serum LH in a dose-dependent manner.

    In plain wordsIn dogs, kisspeptin given alone raised luteinizing hormone levels, and more so at the higher dose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum LH concentration
    Study

    dogn: not reported in source

    anestrus female dogs
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.5 and 1 μg/kg · intravenous · single doseAs given in this study (dog).

    Source sentences

    Summary
    LH and FSH concentrations increased significantly in a dose-dependent manner in groups receiving KP-10 alone (G4, G5)
    2 context sentences
    Summary · context
    Twenty-three clinically healthy anestrus female dogs were randomly allocated into five treatment groups.
    Summary · context
    KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In anestrus female dogs, KP-10 given alone increased serum FSH in a dose-dependent manner.

    In plain wordsIn dogs, kisspeptin given alone raised follicle-stimulating hormone levels, and more so at the higher dose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum FSH concentration
    Study

    dogn: not reported in source

    anestrus female dogs
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.5 and 1 μg/kg · intravenous · single doseAs given in this study (dog).

    Source sentences

    Summary
    LH and FSH concentrations increased significantly in a dose-dependent manner in groups receiving KP-10 alone (G4, G5)
    2 context sentences
    Summary · context
    Twenty-three clinically healthy anestrus female dogs were randomly allocated into five treatment groups.
    Summary · context
    KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In anestrus female dogs, estradiol increased in all groups, not only those given KP-10, and did not reach proestrus levels.

    In plain wordsIn dogs, estradiol rose in every group, including groups without kisspeptin, so the rise is not clearly due to kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableSerum estradiol
    Study

    dogn: not reported in source

    anestrus female dogs
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenous · single doseAs given in this study (dog).

    Source sentences

    Summary
    E2 levels increased in all groups, although not reaching proestrus levels.
    2 context sentences
    Summary · context
    Twenty-three clinically healthy anestrus female dogs were randomly allocated into five treatment groups.
    Summary · context
    KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In anestrus female dogs, KP-10 stimulated LH and FSH release but did not induce clinical estrus.

    In plain wordsIn dogs, kisspeptin raised reproductive hormones but did not bring on a clinical heat (estrus).

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeInduction of clinical estrus
    Study

    dogn: not reported in source

    anestrus female dogs
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.5 and 1 μg/kg · intravenous · single doseAs given in this study (dog).

    Source sentences

    Summary
    KP-10, particularly at 1 μg/kg (G3, G5), effectively stimulated LH and FSH release but did not induce clinical estrus.
    2 context sentences
    Summary · context
    Twenty-three clinically healthy anestrus female dogs were randomly allocated into five treatment groups.
    Summary · context
    KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In anestrus female dogs, only the group given 1 μg/kg KP-10 plus cabergoline had progesterone above 2 ng/mL on day 15.

    In plain wordsIn dogs, only the group given the higher kisspeptin dose with cabergoline had progesterone above 2 ng/mL on day 15.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum progesterone above 2 ng/mL on day 15
    Study

    dogn = 5

    anestrus female dogs
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Progesterone
    > 2 ng/mL
    G3 on day 15

    Source sentences

    Summary
    Only G3 exhibited a P4 increase above 2 ng/mL on day 15, suggesting possible luteinization.
    2 context sentences
    Summary · context
    Twenty-three clinically healthy anestrus female dogs were randomly allocated into five treatment groups.
    Summary · context
    KP-10 was administered intravenously as a single dose, while CB was given orally for 15 consecutive days.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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