Cortexin modulates OPG/RANK/RANKL and TRPC1 expression in cerebral ischemia-reperfusion injury.

Guven C, Türk A, Koçak S, Zencirci B, Yalcin A, Aydın H, Doğukan M

Neurological research10 Aug 2025

PMID40783844DOI10.1080/01616412.2025.2536075PepBankPUB-40783844

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia-reperfusion injury, Cortexin significantly reduced serum total oxidant status.
In plain wordsIn rats with brain ischemia-reperfusion injury, Cortexin reduced blood oxidant status.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseSerum total oxidant status
Study
Wistar albino ratsn: not reported in source
cerebral ischemia-reperfusion injury
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
1 or 2 mg/kgAs given in this study (Wistar albino rats).
Source sentences
Summary
Cortexin significantly reduced TOS (p p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty-five male Wistar albino rats were divided into five groups: control, ischemia (45 minutes), I/R (7 days), I/R + 1 mg/kg Cortexin, and I/R + 2 mg/kg Cortexin.
Summary · context
Immunohistochemical staining was used to assess biomarker expression in brain tissue, while serum total oxidant status (TOS) and total antioxidant status (TAS) were measured using ELISA.
Report a problemFND-4078384401
02AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia-reperfusion injury, Cortexin increased serum total antioxidant status.
In plain wordsIn rats with brain ischemia-reperfusion injury, Cortexin increased blood antioxidant status.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseSerum total antioxidant status
Study
Wistar albino ratsn: not reported in source
cerebral ischemia-reperfusion injury
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
1 or 2 mg/kgAs given in this study (Wistar albino rats).
Source sentences
Summary
Cortexin significantly reduced TOS (p p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty-five male Wistar albino rats were divided into five groups: control, ischemia (45 minutes), I/R (7 days), I/R + 1 mg/kg Cortexin, and I/R + 2 mg/kg Cortexin.
Summary · context
Immunohistochemical staining was used to assess biomarker expression in brain tissue, while serum total oxidant status (TOS) and total antioxidant status (TAS) were measured using ELISA.
Report a problemFND-4078384402
03AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia-reperfusion injury, Cortexin at 2 mg/kg produced antioxidant status above control levels.
In plain wordsIn rats with brain ischemia-reperfusion injury, Cortexin at 2 mg/kg increased antioxidant status above control levels.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseSerum total antioxidant status at higher dose
Study
Wistar albino ratsn: not reported in source
cerebral ischemia-reperfusion injury
Comparator
control
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
2 mg/kgAs given in this study (Wistar albino rats).
Source sentences
Summary
Cortexin significantly reduced TOS (p p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty-five male Wistar albino rats were divided into five groups: control, ischemia (45 minutes), I/R (7 days), I/R + 1 mg/kg Cortexin, and I/R + 2 mg/kg Cortexin.
Summary · context
Immunohistochemical staining was used to assess biomarker expression in brain tissue, while serum total oxidant status (TOS) and total antioxidant status (TAS) were measured using ELISA.
Report a problemFND-4078384403
04AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia-reperfusion injury, Cortexin significantly decreased brain OPG expression.
In plain wordsIn rats with brain ischemia-reperfusion injury, Cortexin decreased brain OPG expression.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseBrain OPG expression
Study
Wistar albino ratsn: not reported in source
cerebral ischemia-reperfusion injury
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
1 or 2 mg/kgAs given in this study (Wistar albino rats).
Source sentences
Summary
Cortexin treatment significantly decreased expression of all markers (p < 0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
Immunohistochemical analysis revealed significantly elevated OPG, RANK, RANKL, and TRPC1 expression in ischemia and I/R groups (p < 0.001).
Summary · context
Thirty-five male Wistar albino rats were divided into five groups: control, ischemia (45 minutes), I/R (7 days), I/R + 1 mg/kg Cortexin, and I/R + 2 mg/kg Cortexin.
Summary · context
Immunohistochemical staining was used to assess biomarker expression in brain tissue, while serum total oxidant status (TOS) and total antioxidant status (TAS) were measured using ELISA.
Report a problemFND-4078384404
05AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia-reperfusion injury, Cortexin significantly decreased brain RANK expression.
In plain wordsIn rats with brain ischemia-reperfusion injury, Cortexin decreased brain RANK expression.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseBrain RANK expression
Study
Wistar albino ratsn: not reported in source
cerebral ischemia-reperfusion injury
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
1 or 2 mg/kgAs given in this study (Wistar albino rats).
Source sentences
Summary
Cortexin treatment significantly decreased expression of all markers (p < 0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
Immunohistochemical analysis revealed significantly elevated OPG, RANK, RANKL, and TRPC1 expression in ischemia and I/R groups (p < 0.001).
Summary · context
Thirty-five male Wistar albino rats were divided into five groups: control, ischemia (45 minutes), I/R (7 days), I/R + 1 mg/kg Cortexin, and I/R + 2 mg/kg Cortexin.
Summary · context
Immunohistochemical staining was used to assess biomarker expression in brain tissue, while serum total oxidant status (TOS) and total antioxidant status (TAS) were measured using ELISA.
Report a problemFND-4078384405
06AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia-reperfusion injury, Cortexin significantly decreased brain RANKL expression.
In plain wordsIn rats with brain ischemia-reperfusion injury, Cortexin decreased brain RANKL expression.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseBrain RANKL expression
Study
Wistar albino ratsn: not reported in source
cerebral ischemia-reperfusion injury
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
1 or 2 mg/kgAs given in this study (Wistar albino rats).
Source sentences
Summary
Cortexin treatment significantly decreased expression of all markers (p < 0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
Immunohistochemical analysis revealed significantly elevated OPG, RANK, RANKL, and TRPC1 expression in ischemia and I/R groups (p < 0.001).
Summary · context
Thirty-five male Wistar albino rats were divided into five groups: control, ischemia (45 minutes), I/R (7 days), I/R + 1 mg/kg Cortexin, and I/R + 2 mg/kg Cortexin.
Summary · context
Immunohistochemical staining was used to assess biomarker expression in brain tissue, while serum total oxidant status (TOS) and total antioxidant status (TAS) were measured using ELISA.
Report a problemFND-4078384406
07AnimalAnimal study (in vivo)Mechanism
In rats with cerebral ischemia-reperfusion injury, Cortexin significantly decreased brain TRPC1 expression.
In plain wordsIn rats with brain ischemia-reperfusion injury, Cortexin decreased brain TRPC1 expression.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseBrain TRPC1 expression
Study
Wistar albino ratsn: not reported in source
cerebral ischemia-reperfusion injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
1 or 2 mg/kgAs given in this study (Wistar albino rats).
Source sentences
Summary
Cortexin treatment significantly decreased expression of all markers (p < 0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
Immunohistochemical analysis revealed significantly elevated OPG, RANK, RANKL, and TRPC1 expression in ischemia and I/R groups (p < 0.001).
Summary · context
Thirty-five male Wistar albino rats were divided into five groups: control, ischemia (45 minutes), I/R (7 days), I/R + 1 mg/kg Cortexin, and I/R + 2 mg/kg Cortexin.
Summary · context
Immunohistochemical staining was used to assess biomarker expression in brain tissue, while serum total oxidant status (TOS) and total antioxidant status (TAS) were measured using ELISA.
Report a problemFND-4078384407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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