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Study · Animal study (in vivo) · mouse · 2025

9 results

NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway.

Zhao X, He M, He L, Han R, Liu Y

Scientific reports7 Aug 2025Cited by 6 (Europe PMC)

PMID40775529 (opens in a new tab)PMCIDPMC12332049 (opens in a new tab)DOI10.1038/s41598-025-14349-6 (opens in a new tab)PepBankPUB-40775529
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In SIRT3 knockout mice, NMN increased myocardial NAD+ content.

    In plain wordsIn mice lacking SIRT3, NMN increased NAD+ in heart tissue.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMyocardial NAD+ content
    Study

    mousen: not reported in source

    SIRT3 knockout mice
    Outcome group
    Energy expenditure and thermogenesis · Cardiovascular
    Studied dose
    Dose not stated · intraperitoneal · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that NMN injection effectively increased the NAD + content as well as the NAD+/NADH ratio within the myocardial tissue of SIRT3 knockout mice and stimulated the expression of SIRT1 protein.
    1 context sentence
    Summary · context
    we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In SIRT3 knockout mice, NMN increased the myocardial NAD+/NADH ratio.

    In plain wordsIn mice lacking SIRT3, NMN increased the NAD+/NADH ratio in heart tissue.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMyocardial NAD+/NADH ratio
    Study

    mousen: not reported in source

    SIRT3 knockout mice
    Outcome group
    Energy expenditure and thermogenesis · Cardiovascular
    Studied dose
    Dose not stated · intraperitoneal · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that NMN injection effectively increased the NAD + content as well as the NAD+/NADH ratio within the myocardial tissue of SIRT3 knockout mice and stimulated the expression of SIRT1 protein.
    1 context sentence
    Summary · context
    we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In SIRT3 knockout mice, NMN increased myocardial SIRT1 protein expression.

    In plain wordsIn mice lacking SIRT3, NMN increased SIRT1 protein in heart tissue.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMyocardial SIRT1 protein
    Study

    mousen: not reported in source

    SIRT3 knockout mice
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · intraperitoneal · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that NMN injection effectively increased the NAD + content as well as the NAD+/NADH ratio within the myocardial tissue of SIRT3 knockout mice and stimulated the expression of SIRT1 protein.
    1 context sentence
    Summary · context
    we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In SIRT3 knockout mice, NMN increased PGC-1α protein expression in myocardial mitochondria.

    In plain wordsIn mice lacking SIRT3, NMN increased PGC-1α protein in heart mitochondria.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial PGC-1alpha protein
    Study

    mousen: not reported in source

    SIRT3 knockout mice
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated · intraperitoneal · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    In addition, protein expression of PGC-1α and its downstream molecules as well as molecules related to subunits of the respiratory chain complex was increased in mouse myocardial mitochondria.
    1 context sentence
    Summary · context
    we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In SIRT3 knockout mice, NMN increased PGC-1α downstream molecule expression in myocardial mitochondria.

    In plain wordsIn mice lacking SIRT3, NMN increased molecules downstream of PGC-1α in heart mitochondria.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePGC-1alpha downstream molecules
    Study

    mousen: not reported in source

    SIRT3 knockout mice
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated · intraperitoneal · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    In addition, protein expression of PGC-1α and its downstream molecules as well as molecules related to subunits of the respiratory chain complex was increased in mouse myocardial mitochondria.
    1 context sentence
    Summary · context
    we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In SIRT3 knockout mice, NMN increased respiratory chain complex subunit-related molecule expression in myocardial mitochondria.

    In plain wordsIn mice lacking SIRT3, NMN increased molecules related to respiratory chain subunits in heart mitochondria.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseRespiratory chain complex-related molecules
    Study

    mousen: not reported in source

    SIRT3 knockout mice
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated · intraperitoneal · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    In addition, protein expression of PGC-1α and its downstream molecules as well as molecules related to subunits of the respiratory chain complex was increased in mouse myocardial mitochondria.
    1 context sentence
    Summary · context
    we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In SIRT3 knockout mice, NMN improved cardiomyocyte structure.

    In plain wordsIn mice lacking SIRT3, NMN improved heart cell structure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableCardiomyocyte structure
    Study

    mousen: not reported in source

    SIRT3 knockout mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intraperitoneal · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Meanwhile, NMN injection improved the cardiomyocyte and mitochondrial structure of mice, ultimately ameliorating cardiac insufficiency in SIRT3 knockout mice.
    1 context sentence
    Summary · context
    we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In SIRT3 knockout mice, NMN improved mitochondrial structure.

    In plain wordsIn mice lacking SIRT3, NMN improved mitochondrial structure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableMitochondrial structure
    Study

    mousen: not reported in source

    SIRT3 knockout mice
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated · intraperitoneal · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Meanwhile, NMN injection improved the cardiomyocyte and mitochondrial structure of mice, ultimately ameliorating cardiac insufficiency in SIRT3 knockout mice.
    1 context sentence
    Summary · context
    we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In SIRT3 knockout mice, NMN ameliorated cardiac insufficiency.

    In plain wordsIn mice lacking SIRT3, NMN reduced impaired heart function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCardiac insufficiency
    Study

    mousen: not reported in source

    SIRT3 knockout mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intraperitoneal · 14 daysAs given in this study (mouse).

    Source sentences

    Summary
    Meanwhile, NMN injection improved the cardiomyocyte and mitochondrial structure of mice, ultimately ameliorating cardiac insufficiency in SIRT3 knockout mice.
    1 context sentence
    Summary · context
    we selected 6-week-old SIRT3 knockout mice with similar body weights of both sexes and performed intraperitoneal injections of NMN over a 14-day period to increase the content of NAD + in the myocardial tissue of the mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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