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Study · Animal study (in vivo) · rat · 2025

6 results

Comparative Analysis of Pioglitazone and Tirzepatide on Body Weight, Glucose Levels, Neuroinflammation, and Oxidative Stress in Diabetic Rats.

Alhowail A, Aldawsari MF, Aldubayan M

Drug design, development and therapy31 Jul 2025Cited by 3 (Europe PMC)

PMID40771859 (opens in a new tab)PMCIDPMC12325112 (opens in a new tab)DOI10.2147/dddt.s525690 (opens in a new tab)PepBankPUB-40771859
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with streptozotocin and nicotinamide-induced type 2 diabetes, tirzepatide increased survival rates.

    In plain wordsIn diabetic rats, tirzepatide increased survival.

    Peptide
    Tirzepatide
    Outcome
    IncreaseSurvival rate
    Study

    ratn = 10

    Streptozotocin and nicotinamide-induced type 2 diabetes in male albino rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    The TZP and PIO increased survival rates and cognitive function as well as decreased glucose levels, neuroinflammation, and oxidative stress in diabetic rats, with PIO demonstrating a more pronounced effect on neuroinflammation and oxidative stress, contrasted with TZP.
    2 context sentences
    Summary · context
    A total of six distinct groups of sixty albino rat males (n = 10) were allocated at random: Saline, TZP, PIO, T2DM, T2DM+TZP, and T2DM+PIO.
    Summary · context
    Intramuscular doses of streptozotocin (50 mg/kg) and nicotinamide (120 mg/kg) precipitated T2DM.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with streptozotocin and nicotinamide-induced type 2 diabetes, tirzepatide increased cognitive function.

    In plain wordsIn diabetic rats, tirzepatide improved performance in memory and learning tests.

    Peptide
    Tirzepatide
    Outcome
    IncreaseCognitive function (Y-maze, novel object recognition)
    Study

    ratn = 10

    Streptozotocin and nicotinamide-induced type 2 diabetes in male albino rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    The TZP and PIO increased survival rates and cognitive function as well as decreased glucose levels, neuroinflammation, and oxidative stress in diabetic rats, with PIO demonstrating a more pronounced effect on neuroinflammation and oxidative stress, contrasted with TZP.
    2 context sentences
    Summary · context
    A total of six distinct groups of sixty albino rat males (n = 10) were allocated at random: Saline, TZP, PIO, T2DM, T2DM+TZP, and T2DM+PIO.
    Summary · context
    Intramuscular doses of streptozotocin (50 mg/kg) and nicotinamide (120 mg/kg) precipitated T2DM.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with streptozotocin and nicotinamide-induced type 2 diabetes, tirzepatide decreased glucose levels.

    In plain wordsIn diabetic rats, tirzepatide lowered blood glucose.

    Peptide
    Tirzepatide
    Outcome
    DecreaseGlucose levels
    Study

    ratn = 10

    Streptozotocin and nicotinamide-induced type 2 diabetes in male albino rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    The TZP and PIO increased survival rates and cognitive function as well as decreased glucose levels, neuroinflammation, and oxidative stress in diabetic rats, with PIO demonstrating a more pronounced effect on neuroinflammation and oxidative stress, contrasted with TZP.
    2 context sentences
    Summary · context
    A total of six distinct groups of sixty albino rat males (n = 10) were allocated at random: Saline, TZP, PIO, T2DM, T2DM+TZP, and T2DM+PIO.
    Summary · context
    Intramuscular doses of streptozotocin (50 mg/kg) and nicotinamide (120 mg/kg) precipitated T2DM.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with streptozotocin and nicotinamide-induced type 2 diabetes, tirzepatide decreased neuroinflammation.

    In plain wordsIn diabetic rats, tirzepatide reduced signs of brain inflammation.

    Peptide
    Tirzepatide
    Outcome
    DecreaseNeuroinflammation (TNF-alpha, IL-6, IL-1 beta)
    Study

    ratn = 10

    Streptozotocin and nicotinamide-induced type 2 diabetes in male albino rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    The TZP and PIO increased survival rates and cognitive function as well as decreased glucose levels, neuroinflammation, and oxidative stress in diabetic rats, with PIO demonstrating a more pronounced effect on neuroinflammation and oxidative stress, contrasted with TZP.
    2 context sentences
    Summary · context
    A total of six distinct groups of sixty albino rat males (n = 10) were allocated at random: Saline, TZP, PIO, T2DM, T2DM+TZP, and T2DM+PIO.
    Summary · context
    Intramuscular doses of streptozotocin (50 mg/kg) and nicotinamide (120 mg/kg) precipitated T2DM.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with streptozotocin and nicotinamide-induced type 2 diabetes, tirzepatide decreased oxidative stress.

    In plain wordsIn diabetic rats, tirzepatide reduced signs of oxidative stress.

    Peptide
    Tirzepatide
    Outcome
    DecreaseOxidative stress (SOD, GPx, MDA, lipid peroxidation)
    Study

    ratn = 10

    Streptozotocin and nicotinamide-induced type 2 diabetes in male albino rats
    Comparator
    Untreated diabetic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    The TZP and PIO increased survival rates and cognitive function as well as decreased glucose levels, neuroinflammation, and oxidative stress in diabetic rats, with PIO demonstrating a more pronounced effect on neuroinflammation and oxidative stress, contrasted with TZP.
    2 context sentences
    Summary · context
    A total of six distinct groups of sixty albino rat males (n = 10) were allocated at random: Saline, TZP, PIO, T2DM, T2DM+TZP, and T2DM+PIO.
    Summary · context
    Intramuscular doses of streptozotocin (50 mg/kg) and nicotinamide (120 mg/kg) precipitated T2DM.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, pioglitazone had a more pronounced effect than tirzepatide on neuroinflammation and oxidative stress.

    In plain wordsIn diabetic rats, pioglitazone reduced brain inflammation and oxidative stress more than tirzepatide did.

    Peptide
    Tirzepatide
    Outcome
    Not applicableNeuroinflammation and oxidative stress, tirzepatide versus pioglitazone
    Study

    ratn = 10

    Streptozotocin and nicotinamide-induced type 2 diabetes in male albino rats
    Comparator
    Pioglitazone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    with PIO demonstrating a more pronounced effect on neuroinflammation and oxidative stress, contrasted with TZP.
    2 context sentences
    Summary · context
    A total of six distinct groups of sixty albino rat males (n = 10) were allocated at random: Saline, TZP, PIO, T2DM, T2DM+TZP, and T2DM+PIO.
    Summary · context
    Intramuscular doses of streptozotocin (50 mg/kg) and nicotinamide (120 mg/kg) precipitated T2DM.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:07 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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