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Study · Other design · 2025

8 results

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.

Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM

HSS journal : the musculoskeletal journal of Hospital for Special Surgery31 Jul 2025Cited by 12 (Europe PMC)

PMID40756949 (opens in a new tab)PMCIDPMC12313605 (opens in a new tab)DOI10.1177/15563316251355551 (opens in a new tab)PepBankPUB-40756949
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalOther designMechanism

    In the mostly preclinical studies reviewed, BPC‑157 enhanced growth hormone receptor expression and pathways involved in cell growth and angiogenesis.

    In plain wordsIn preclinical studies, BPC‑157 was linked to higher growth hormone receptor levels and to cell growth and blood vessel pathways, according to this review.

    Peptide
    BPC-157
    Outcome
    IncreaseGrowth hormone receptor expression
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC-157 enhances growth hormone receptor expression and several pathways involved in cell growth and angiogenesis
    1 context sentence
    Summary · context
    After duplicates were removed, 36 studies were included (35 preclinical studies, 1 clinical study).
  2. 02AnimalOther designMechanism

    In the mostly preclinical studies reviewed, BPC‑157 reduced inflammatory cytokines.

    In plain wordsIn preclinical studies, BPC‑157 was linked to lower inflammatory cytokine levels, according to this review.

    Peptide
    BPC-157
    Outcome
    DecreaseInflammatory cytokines
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The studies suggest that BPC-157 enhances growth hormone receptor expression and several pathways involved in cell growth and angiogenesis, while reducing inflammatory cytokines.
    1 context sentence
    Summary · context
    After duplicates were removed, 36 studies were included (35 preclinical studies, 1 clinical study).
  3. 03AnimalOther designEfficacy outcome

    In preclinical models, BPC‑157 improved functional, structural and biomechanical outcomes in muscle injuries.

    In plain wordsIn preclinical models, BPC‑157 was linked to better muscle healing, according to this review.

    Peptide
    BPC-157
    Outcome
    IncreaseMuscle injury outcomes
    Study

    n: not reported in source

    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In preclinical models, BPC-157 improved functional, structural, and biomechanical outcomes in muscle, tendon, ligament, and bony injuries.
    1 context sentence
    Summary · context
    After duplicates were removed, 36 studies were included (35 preclinical studies, 1 clinical study).
  4. 04AnimalOther designEfficacy outcome

    In preclinical models, BPC‑157 improved functional, structural and biomechanical outcomes in tendon injuries.

    In plain wordsIn preclinical models, BPC‑157 was linked to better tendon healing, according to this review.

    Peptide
    BPC-157
    Outcome
    IncreaseTendon injury outcomes
    Study

    n: not reported in source

    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In preclinical models, BPC-157 improved functional, structural, and biomechanical outcomes in muscle, tendon, ligament, and bony injuries.
    1 context sentence
    Summary · context
    After duplicates were removed, 36 studies were included (35 preclinical studies, 1 clinical study).
  5. 05AnimalOther designEfficacy outcome

    In preclinical models, BPC‑157 improved functional, structural and biomechanical outcomes in ligament injuries.

    In plain wordsIn preclinical models, BPC‑157 was linked to better ligament healing, according to this review.

    Peptide
    BPC-157
    Outcome
    IncreaseLigament injury outcomes
    Study

    n: not reported in source

    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In preclinical models, BPC-157 improved functional, structural, and biomechanical outcomes in muscle, tendon, ligament, and bony injuries.
    1 context sentence
    Summary · context
    After duplicates were removed, 36 studies were included (35 preclinical studies, 1 clinical study).
  6. 06AnimalOther designEfficacy outcome

    In preclinical models, BPC‑157 improved functional, structural and biomechanical outcomes in bony injuries.

    In plain wordsIn preclinical models, BPC‑157 was linked to better bone healing, according to this review.

    Peptide
    BPC-157
    Outcome
    IncreaseBone injury outcomes
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In preclinical models, BPC-157 improved functional, structural, and biomechanical outcomes in muscle, tendon, ligament, and bony injuries.
    1 context sentence
    Summary · context
    After duplicates were removed, 36 studies were included (35 preclinical studies, 1 clinical study).
  7. 07AnimalOther designPharmacokinetics

    The reviewed studies report that BPC‑157 is metabolized in the liver, has a half-life of less than 30 minutes and is cleared by the kidneys.

    In plain wordsAccording to this review, BPC‑157 is broken down in the liver, lasts under 30 minutes in the body, and is cleared by the kidneys.

    Peptide
    BPC-157
    Outcome
    Not applicablePlasma half-life
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    half-life
    < 30 minutes
    BPC-157

    Source sentences

    Summary
    BPC-157 is metabolized in the liver, with a half-life of less than 30 minutes, and is cleared by the kidneys.
    1 context sentence
    Summary · context
    After duplicates were removed, 36 studies were included (35 preclinical studies, 1 clinical study).
  8. 08AnimalOther designSafety outcome

    In the preclinical safety studies reviewed, BPC‑157 showed no adverse effects across several organ systems.

    In plain wordsIn preclinical safety studies, BPC‑157 showed no harmful effects in several organ systems, according to this review.

    Peptide
    BPC-157
    Outcome
    No significant changePreclinical organ-system safety
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preclinical safety studies showed no adverse effects across several organ systems.
    1 context sentence
    Summary · context
    After duplicates were removed, 36 studies were included (35 preclinical studies, 1 clinical study).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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