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Study · Animal study (in vivo) · mouse · 2025

8 results

Nicotinamide Mononucleotide Alleviates Aging Defects in Hutchinson-Gilford Progeria Syndrome.

Xu Y, Wu M, Fan Y, Zhang J, Xue D, Zhang M, Shao R, Cai L, Liao X, Zhang L, Zhang J

FASEB journal : official publication of the Federation of American Societies for Experimental Biology1 Aug 2025Cited by 2 (Europe PMC)

PMID40742332 (opens in a new tab)DOI10.1096/fj.202500469rr (opens in a new tab)PepBankPUB-40742332
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In G608G transgenic mice, NMN administration improved gonadal function.

    In plain wordsIn mice with the G608G mutation, NMN improved gonadal function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGonadal function
    Study

    mousen: not reported in source

    G608G transgenic mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 4 monthsAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, 4 months of NMN administration in G608G transgenic mouse models resulted in significant improvements in gonadal function, cardiovascular parameters, skin pathology, and lifespan extension.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In G608G transgenic mice, NMN administration improved cardiovascular parameters.

    In plain wordsIn mice with the G608G mutation, NMN improved cardiovascular measures.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableCardiovascular parameters
    Study

    mousen: not reported in source

    G608G transgenic mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · 4 monthsAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, 4 months of NMN administration in G608G transgenic mouse models resulted in significant improvements in gonadal function, cardiovascular parameters, skin pathology, and lifespan extension.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In G608G transgenic mice, NMN administration improved skin pathology.

    In plain wordsIn mice with the G608G mutation, NMN improved skin abnormalities.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableSkin pathology
    Study

    mousen: not reported in source

    G608G transgenic mice
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 4 monthsAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, 4 months of NMN administration in G608G transgenic mouse models resulted in significant improvements in gonadal function, cardiovascular parameters, skin pathology, and lifespan extension.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In G608G transgenic mice, NMN administration extended lifespan.

    In plain wordsIn mice with the G608G mutation, NMN increased lifespan.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseLifespan
    Study

    mousen: not reported in source

    G608G transgenic mice
    Outcome group
    Mortality · Aging and longevity
    Studied dose
    Dose not stated · 4 monthsAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, 4 months of NMN administration in G608G transgenic mouse models resulted in significant improvements in gonadal function, cardiovascular parameters, skin pathology, and lifespan extension.
  5. 05LabIn vitro (cells)Efficacy outcome

    In patient-derived HGPS cells, NMN enhanced NAD+ biosynthesis.

    In plain wordsIn lab tests with progeria-derived cells, NMN increased NAD+ production.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNAD+ biosynthesis
    Study

    humann: not reported in source

    patient-derived induced pluripotent stem cell-mesenchymal stem cells
    Outcome group
    Energy expenditure and thermogenesis · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In patient-derived induced pluripotent stem cell-mesenchymal stem cells, NMN supplementation enhanced NAD+ biosynthesis, restored mitochondrial function, reduced DNA damage, and mitigated oxidative stress.
  6. 06LabIn vitro (cells)Efficacy outcome

    In patient-derived HGPS cells, NMN restored mitochondrial function.

    In plain wordsIn lab tests with progeria-derived cells, NMN restored mitochondrial function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableMitochondrial function
    Study

    humann: not reported in source

    patient-derived induced pluripotent stem cell-mesenchymal stem cells
    Outcome group
    Mitochondrial function · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In patient-derived induced pluripotent stem cell-mesenchymal stem cells, NMN supplementation enhanced NAD+ biosynthesis, restored mitochondrial function, reduced DNA damage, and mitigated oxidative stress.
  7. 07LabIn vitro (cells)Efficacy outcome

    In patient-derived HGPS cells, NMN reduced DNA damage.

    In plain wordsIn lab tests with progeria-derived cells, NMN reduced DNA damage.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseDNA damage
    Study

    humann: not reported in source

    patient-derived induced pluripotent stem cell-mesenchymal stem cells
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In patient-derived induced pluripotent stem cell-mesenchymal stem cells, NMN supplementation enhanced NAD+ biosynthesis, restored mitochondrial function, reduced DNA damage, and mitigated oxidative stress.
  8. 08LabIn vitro (cells)Efficacy outcome

    In patient-derived HGPS cells, NMN mitigated oxidative stress.

    In plain wordsIn lab tests with progeria-derived cells, NMN reduced oxidative stress.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOxidative stress
    Study

    humann: not reported in source

    patient-derived induced pluripotent stem cell-mesenchymal stem cells
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In patient-derived induced pluripotent stem cell-mesenchymal stem cells, NMN supplementation enhanced NAD+ biosynthesis, restored mitochondrial function, reduced DNA damage, and mitigated oxidative stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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