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Study · Case report or series · n = 1 · 2025

2 results

Type 2 Diabetes in a 4-Year-Old With Obesity: Considerations for Use of Semaglutide and Bariatric Surgery in Children.

Connard J, Simonian A, Monzavi R, Samakar K, Vidmar AP

JCEM case reports17 Jul 2025

PMID40689302 (opens in a new tab)PMCIDPMC12269755 (opens in a new tab)DOI10.1210/jcemcr/luaf142 (opens in a new tab)PepBankPUB-40689302
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In a 4-year-old with obesity and type 2 diabetes on metformin, HbA1c improved to 5.1% by 27 months after semaglutide was started.

    In plain wordsIn one 4-year-old with obesity and type 2 diabetes, blood sugar control improved after semaglutide was added.

    Peptide
    Semaglutide
    Outcome
    DecreaseHbA1c at 27 months
    Study

    n = 1

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    titrated to 2 mg weeklyAs given in this study (human).

    Measurements

    HbA1c
    5.1%
    27 months

    Source sentences

    Summary
    By 27 months, her HbA1c improved to 5.1%
    2 context sentences
    Summary · context
    so semaglutide was started and titrated to 2 mg weekly.
    Summary · context
    A 4-year-old Hispanic female with early-onset obesity and newly diagnosed T2D presented with a hemoglobin A1c (HbA1c) level of 8.0% (reference: < 5.7%), a fasting glucose of 147 mg/dL (SI units: 8.17 mmol/L) (reference: 70-115 mg/dL [3.33-6.39 mmol/L]), and a body mass index (BMI) of 41 kg/m².
  2. 02HumanCase report or seriesEfficacy outcome

    In a 4-year-old with obesity and type 2 diabetes on metformin, the percent above the 95th BMI percentile fell by 12% by 27 months after semaglutide was started.

    In plain wordsIn one 4-year-old with obesity, body mass index relative to the 95th percentile fell after semaglutide was added.

    Peptide
    Semaglutide
    Outcome
    DecreasePercent above the 95th BMI percentile
    Study

    n = 1

    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    titrated to 2 mg weeklyAs given in this study (human).

    Measurements

    reduction in %BMIp95
    12%
    27 months

    Source sentences

    Summary
    overall, she had a 12% reduction in her percent above the 95th percentile (%BMIp95; BMI 41 kg/m²→35 kg/m²; %BMIp95 = 205%→190%).
    2 context sentences
    Summary · context
    so semaglutide was started and titrated to 2 mg weekly.
    Summary · context
    A 4-year-old Hispanic female with early-onset obesity and newly diagnosed T2D presented with a hemoglobin A1c (HbA1c) level of 8.0% (reference: < 5.7%), a fasting glucose of 147 mg/dL (SI units: 8.17 mmol/L) (reference: 70-115 mg/dL [3.33-6.39 mmol/L]), and a body mass index (BMI) of 41 kg/m².

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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