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Study · Ex vivo tissue · mouse · 2025

6 results

Reverse Effects of Nicotinamide Mononucleotide Supplementation on Declining Quality of Oocytes With Polycystic Ovary Syndrome.

Fan Y, Hu Q, Wu X, Lang P, Wei Y, Yi R, He C, Geng T, Zhao C, Zhou S, Zhang J, Ling X

FASEB journal : official publication of the Federation of American Societies for Experimental Biology1 Jul 2025Cited by 3 (Europe PMC)

PMID40678956 (opens in a new tab)PMCIDPMC12272325 (opens in a new tab)DOI10.1096/fj.202500921r (opens in a new tab)PepBankPUB-40678956
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In PCOS mouse oocytes, NMN restored NAD+ homeostasis.

    In plain wordsIn lab tests, NMN restored NAD+ balance in oocytes from mice with PCOS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableOocyte NAD+ homeostasis
    Study

    mousen: not reported in source

    PCOS mouse oocytes during in vitro maturation
    Outcome group
    Energy expenditure and thermogenesis · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study demonstrates that nicotinamide mononucleotide (NMN) not only restores NAD+ homeostasis in oocytes from PCOS mice but also enhances the developmental rate of PCOS oocytes during in vitro maturation (IVM).
  2. 02LabEx vivo tissueEfficacy outcome

    In PCOS mouse oocytes, NMN increased the developmental rate during in vitro maturation.

    In plain wordsIn lab tests, NMN increased development during maturation of oocytes from mice with PCOS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOocyte developmental rate
    Study

    mousen: not reported in source

    PCOS mouse oocytes during in vitro maturation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study demonstrates that nicotinamide mononucleotide (NMN) not only restores NAD+ homeostasis in oocytes from PCOS mice but also enhances the developmental rate of PCOS oocytes during in vitro maturation (IVM).
  3. 03LabEx vivo tissueEfficacy outcome

    In PCOS mouse oocytes, transcriptomic analysis and experimental validation suggested that NMN mitigated oxidative stress.

    In plain wordsIn lab tests, analyses suggested that NMN reduced oxidative stress in oocytes from mice with PCOS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOocyte oxidative stress
    Study

    mousen: not reported in source

    PCOS mouse oocytes during in vitro maturation
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Transcriptomic analysis and experimental validation suggest that NMN helps reverse the decline in PCOS oocyte quality by mitigating oxidative stress, improving mitochondrial function, and preserving spindle morphology.
    1 context sentence
    Summary · context
    Our study demonstrates that nicotinamide mononucleotide (NMN) not only restores NAD+ homeostasis in oocytes from PCOS mice but also enhances the developmental rate of PCOS oocytes during in vitro maturation (IVM).
  4. 04LabEx vivo tissueEfficacy outcome

    In PCOS mouse oocytes, transcriptomic analysis and experimental validation suggested that NMN improved mitochondrial function.

    In plain wordsIn lab tests, analyses suggested that NMN improved mitochondrial function in oocytes from mice with PCOS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOocyte mitochondrial function
    Study

    mousen: not reported in source

    PCOS mouse oocytes during in vitro maturation
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Transcriptomic analysis and experimental validation suggest that NMN helps reverse the decline in PCOS oocyte quality by mitigating oxidative stress, improving mitochondrial function, and preserving spindle morphology.
    1 context sentence
    Summary · context
    Our study demonstrates that nicotinamide mononucleotide (NMN) not only restores NAD+ homeostasis in oocytes from PCOS mice but also enhances the developmental rate of PCOS oocytes during in vitro maturation (IVM).
  5. 05LabEx vivo tissueEfficacy outcome

    In PCOS mouse oocytes, transcriptomic analysis and experimental validation suggested that NMN preserved spindle morphology.

    In plain wordsIn lab tests, analyses suggested that NMN preserved spindle structure in oocytes from mice with PCOS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableOocyte spindle morphology
    Study

    mousen: not reported in source

    PCOS mouse oocytes during in vitro maturation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Transcriptomic analysis and experimental validation suggest that NMN helps reverse the decline in PCOS oocyte quality by mitigating oxidative stress, improving mitochondrial function, and preserving spindle morphology.
    1 context sentence
    Summary · context
    Our study demonstrates that nicotinamide mononucleotide (NMN) not only restores NAD+ homeostasis in oocytes from PCOS mice but also enhances the developmental rate of PCOS oocytes during in vitro maturation (IVM).
  6. 06LabEx vivo tissueMechanism

    In PCOS mouse oocytes, NMN supplementation increased SIRT1 expression.

    In plain wordsIn lab tests, NMN increased SIRT1 expression in oocytes from mice with PCOS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOocyte SIRT1 expression
    Study

    mousen: not reported in source

    PCOS mouse oocytes during in vitro maturation
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, we found that NMN supplementation upregulates SIRT1 expression, which responds to fluctuations in NAD+ levels through the NAD+ salvage pathway regulated by nicotinamide mononucleotide adenylyltransferase (NMNAT).
    1 context sentence
    Summary · context
    Our study demonstrates that nicotinamide mononucleotide (NMN) not only restores NAD+ homeostasis in oocytes from PCOS mice but also enhances the developmental rate of PCOS oocytes during in vitro maturation (IVM).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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