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Study · Measured the body's own peptide · 2025

4 results

Association Between Thymosin β4 and Coronary Arterial Lesions in Children with Kawasaki Disease.

Wu J, Yang P, Zhang J, Chen Z, Wei Y, Su Y, Yi Q

Journal of inflammation research3 Jul 2025

PMID40631047 (opens in a new tab)PMCIDPMC12235015 (opens in a new tab)DOI10.2147/jir.s519589 (opens in a new tab)PepBankPUB-40631047
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In children with Kawasaki disease, serum Tβ4 levels were significantly lower than in healthy controls.

    In plain wordsIn children with Kawasaki disease, the body's own Tβ4 levels in blood were lower than in healthy children.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseSerum Tβ4 level in Kawasaki disease versus healthy controls
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    Serum Tβ4 levels were significantly lower in patients with KD compared to healthy controls and were further reduced in patients with CALs.
    2 context sentences
    Summary · context
    Serum Tβ4 levels were measured using enzyme-linked immunosorbent assay (ELISA) in children with KD and age-matched healthy controls.
    Summary · context
    The KD group was further categorized into patients with and without CALs.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In children with Kawasaki disease, serum Tβ4 levels were further reduced in those with coronary artery lesions (CALs).

    In plain wordsIn children with Kawasaki disease, the body's own Tβ4 levels were lowest in those with heart artery lesions.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseSerum Tβ4 level in Kawasaki disease with coronary artery lesions
    Study

    n: not reported in source

    Comparator
    Kawasaki disease without coronary artery lesions
    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    Serum Tβ4 levels were significantly lower in patients with KD compared to healthy controls and were further reduced in patients with CALs.
    2 context sentences
    Summary · context
    Serum Tβ4 levels were measured using enzyme-linked immunosorbent assay (ELISA) in children with KD and age-matched healthy controls.
    Summary · context
    The KD group was further categorized into patients with and without CALs.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In children with Kawasaki disease, serum Tβ4 levels increased significantly after intravenous immunoglobulin (IVIG) treatment.

    In plain wordsIn children with Kawasaki disease, the body's own Tβ4 levels rose after treatment with intravenous immunoglobulin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSerum Tβ4 level after IVIG treatment
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    After intravenous immunoglobulin (IVIG) treatment, Tβ4 levels significantly increased.
    2 context sentences
    Summary · context
    Serum Tβ4 levels were measured using enzyme-linked immunosorbent assay (ELISA) in children with KD and age-matched healthy controls.
    Summary · context
    The KD group was further categorized into patients with and without CALs.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In children with Kawasaki disease, Tβ4 levels were negatively correlated with several pro-inflammatory and anti-inflammatory cytokines.

    In plain wordsIn children with Kawasaki disease, lower natural Tβ4 levels were linked to higher levels of several inflammation-related proteins.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCorrelation of Tβ4 with cytokines
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    Tβ4 levels were negatively correlated with several pro-inflammatory (eg, TNF-α, IL-1β) and anti-inflammatory cytokines (eg, IL-4, IL-10).
    2 context sentences
    Summary · context
    Serum Tβ4 levels were measured using enzyme-linked immunosorbent assay (ELISA) in children with KD and age-matched healthy controls.
    Summary · context
    The KD group was further categorized into patients with and without CALs.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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