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Study · Not a test of the peptide alone · 2025

7 results

CagriSema drives weight loss in rats by reducing energy intake and preserving energy expenditure.

Jacobsen JM, Halling JF, Blom I, Moreno Martinez J, Hald B, Pedersen K, Fels JJ, Snitker S, Secher A, Lundh S, le Roux CW, Raun K, Reitman ML, Kuhre RE

Nature metabolism8 Jul 2025Cited by 8 (Europe PMC)

PMID40629149 (opens in a new tab)PMCIDPMC12286864 (opens in a new tab)DOI10.1038/s42255-025-01324-8 (opens in a new tab)PepBankPUB-40629149
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01AnimalNot a test of Cagrilintide aloneAnimal study (in vivo)Efficacy outcome

    In rats, CagriSema produced 12% weight loss.

    In plain wordsIn rats, CagriSema led to 12% weight loss.

    Peptide
    Cagrilintide
    Outcome
    DecreaseBody weight loss
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    Weight loss
    12%
    CagriSema

    Source sentences

    Summary
    Quantifying CagriSema's action on energy intake and expenditure in rats we observe 12% weight loss with a 39% reduction in food intake.

    In this study, Cagrilintide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cagrilintide.

  2. 02AnimalNot a test of Cagrilintide aloneAnimal study (in vivo)Efficacy outcome

    In rats, CagriSema reduced food intake by 39%.

    In plain wordsIn rats, CagriSema lowered food intake by 39%.

    Peptide
    Cagrilintide
    Outcome
    DecreaseFood intake
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Appetite and food intake · Metabolic and weight

    Measurements

    Food intake reduction
    39%
    CagriSema

    Source sentences

    Summary
    Quantifying CagriSema's action on energy intake and expenditure in rats we observe 12% weight loss with a 39% reduction in food intake.

    In this study, Cagrilintide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cagrilintide.

  3. 03AnimalNot a test of Cagrilintide aloneAnimal study (in vivo)Mechanism

    In rats, CagriSema blunted metabolic adaptation, and about one-third of its weight loss arose from an effect on energy expenditure.

    In plain wordsIn rats, about one-third of the weight loss with CagriSema came from an effect on energy use, not only from eating less.

    Peptide
    Cagrilintide
    Outcome
    Not applicableEnergy expenditure and metabolic adaptation
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Here, we show that CagriSema blunts metabolic adaptation in rats.
    1 context sentence
    Summary · context
    Therefore, approximately one-third of CagriSema's weight loss efficacy arises from an effect on energy expenditure, the blunting of metabolic adaptation, which contributes to the successful treatment of obesity.

    In this study, Cagrilintide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cagrilintide.

  4. 04AnimalNot a test of Cagrilintide aloneAnimal study (in vivo)Mechanism

    In rats, matching the weight loss of CagriSema by diet required a 51% decrease in food intake, whereas pair-feeding caused less weight loss.

    In plain wordsIn rats, matching the weight loss of CagriSema by diet alone needed a 51% cut in food intake; pair-feeding gave less weight loss.

    Peptide
    Cagrilintide
    Outcome
    Not applicableFood intake reduction needed to match CagriSema weight loss
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Appetite and food intake · Metabolic and weight

    Measurements

    Food intake decrease needed for weight matching
    51%
    weight-matched rats

    Source sentences

    Summary
    By contrast, pair-feeding causes less-pronounced weight loss, while weight matching requires a 51% decrease in food intake.

    In this study, Cagrilintide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cagrilintide.

  5. 05AnimalNot a test of Semaglutide aloneAnimal study (in vivo)Efficacy outcome

    In rats, the combination CagriSema produced 12% weight loss.

    In plain wordsIn rats, the two-drug combination CagriSema led to 12% weight loss.

    Peptide
    Semaglutide
    Outcome
    DecreaseBody weight loss with CagriSema
    Study

    ratn: not reported in source

    Outcome group
    Body weight · Metabolic and weight

    Measurements

    Weight loss
    12%
    CagriSema

    Source sentences

    Summary
    Quantifying CagriSema's action on energy intake and expenditure in rats we observe 12% weight loss with a 39% reduction in food intake.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  6. 06AnimalNot a test of Semaglutide aloneAnimal study (in vivo)Efficacy outcome

    In rats, the combination CagriSema reduced food intake by 39%.

    In plain wordsIn rats, the two-drug combination CagriSema cut food intake by 39%.

    Peptide
    Semaglutide
    Outcome
    DecreaseFood intake reduction with CagriSema
    Study

    ratn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight

    Measurements

    Food intake reduction
    39%
    CagriSema

    Source sentences

    Summary
    Quantifying CagriSema's action on energy intake and expenditure in rats we observe 12% weight loss with a 39% reduction in food intake.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  7. 07AnimalNot a test of Semaglutide aloneAnimal study (in vivo)Mechanism

    In rats, pair-feeding caused less weight loss than CagriSema, and weight matching needed a 51% cut in food intake, so about one-third of the CagriSema weight loss came from an effect on energy expenditure.

    In plain wordsIn rats, about one-third of the weight loss from the combination CagriSema came from an effect on energy expenditure, not only from eating less.

    Peptide
    Semaglutide
    Outcome
    MixedEnergy expenditure and weight loss versus pair-feeding with CagriSema
    Study

    ratn: not reported in source

    Comparator
    Pair-fed and weight-matched rats
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    Food intake decrease needed for weight matching
    51%
    weight-matched rats

    Source sentences

    Summary
    By contrast, pair-feeding causes less-pronounced weight loss, while weight matching requires a 51% decrease in food intake. Therefore, approximately one-third of CagriSema's weight loss efficacy arises from an effect on energy expenditure, the blunting of metabolic adaptation, which contributes to t…

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 38Current

    28 Oct 2026, 02:04 UTC

    The same notice was added 36 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.

    Study results updated

  2. Version 2

    9 Oct 2026, 03:06 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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