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Study · Randomized controlled trial · n = 58 · 2025

6 results

[Proinflammatory cytokines - as a marker of the effectiveness of neuroprotection in children with perinatal nervous system damage].

Degtyareva VG, Drobyshev VA

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2025

PMID40577182 (opens in a new tab)DOI10.17116/jnevro202512506162 (opens in a new tab)PepBankPUB-40577182
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In infants with moderate perinatal CNS damage, adjunctive Cortexin reduced IL-Iß, while standard therapy alone did not correct cytokine levels.

    In plain wordsIn infants with moderate perinatal brain damage, added Cortexin reduced IL-Iß, while standard therapy alone did not correct cytokine levels.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseSerum IL-Iß in moderate perinatal CNS damage
    Study

    n = 58

    Comparator
    standard therapy alone in the same severity group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    IL-Iß decrease
    1.4 fold
    subgroup 2A by 3 months from baseline

    Source sentences

    Summary
    In subgroup 2A, the concentration of IL-Iß decreased by 1.4 times, TNF-α by 1.2 times (p=0.038) by 3 months (p=0.037) from baseline values, whereas in patients of subgroup 2B, no correction of cytokine levels was observed.
    4 context sentences
    Summary · context
    146 children (86 boys, 60 girls) aged from 20 days to 6 months (the average age of boys was 2.7±1.2, and girls 2.9±1.1 months) with CNS PP were examined.
    Summary · context
    Depending on the severity of CNS PP, patients were divided into 3 groups: the 1st (n=50) included patients with severe CNS PP, the 2nd (n=58) - moderate and the 3rd (n=38) - with mild severity.
    Summary · context
    By random sampling, each group was divided into 2 subgroups: patients of subgroups 1A, 2A, and 3A were prescribed Cortexin in addition to standard therapy in accordance with current clinical guidelines.
    Summary · context
    Patients in subgroups 1B, 2B, and 3B received only standard therapy.
  2. 02HumanRandomized controlled trialMechanism

    In infants with moderate perinatal CNS damage, adjunctive Cortexin reduced TNF-α, while standard therapy alone did not correct cytokine levels.

    In plain wordsIn infants with moderate perinatal brain damage, added Cortexin reduced TNF-α, while standard therapy alone did not correct cytokine levels.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseSerum TNF-α in moderate perinatal CNS damage
    Study

    n = 58

    Comparator
    standard therapy alone in the same severity group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    TNF-α decrease
    1.2 fold
    subgroup 2A by 3 months from baseline

    Source sentences

    Summary
    In subgroup 2A, the concentration of IL-Iß decreased by 1.4 times, TNF-α by 1.2 times (p=0.038) by 3 months (p=0.037) from baseline values, whereas in patients of subgroup 2B, no correction of cytokine levels was observed.
    4 context sentences
    Summary · context
    146 children (86 boys, 60 girls) aged from 20 days to 6 months (the average age of boys was 2.7±1.2, and girls 2.9±1.1 months) with CNS PP were examined.
    Summary · context
    Depending on the severity of CNS PP, patients were divided into 3 groups: the 1st (n=50) included patients with severe CNS PP, the 2nd (n=58) - moderate and the 3rd (n=38) - with mild severity.
    Summary · context
    By random sampling, each group was divided into 2 subgroups: patients of subgroups 1A, 2A, and 3A were prescribed Cortexin in addition to standard therapy in accordance with current clinical guidelines.
    Summary · context
    Patients in subgroups 1B, 2B, and 3B received only standard therapy.
  3. 03HumanRandomized controlled trialMechanism

    In infants with severe perinatal CNS damage, adjunctive Cortexin reduced IL-Iß more than standard therapy alone.

    In plain wordsIn infants with severe perinatal brain damage, added Cortexin reduced IL-Iß more than standard therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseSerum IL-Iß in severe perinatal CNS damage
    Study

    n = 50

    Comparator
    standard therapy alone in the same severity group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    IL-Iß decrease
    1.5 fold
    subgroup 1A after treatment

    Source sentences

    Summary
    In subgroup 1A, the concentration of IL-Iß decreased by 1.5 times after treatment (p=0.022), and TNF-α by 1.4 times (p=0.033), which was statistically significantly higher than the similar changes in subgroup 1B.
    4 context sentences
    Summary · context
    146 children (86 boys, 60 girls) aged from 20 days to 6 months (the average age of boys was 2.7±1.2, and girls 2.9±1.1 months) with CNS PP were examined.
    Summary · context
    Depending on the severity of CNS PP, patients were divided into 3 groups: the 1st (n=50) included patients with severe CNS PP, the 2nd (n=58) - moderate and the 3rd (n=38) - with mild severity.
    Summary · context
    By random sampling, each group was divided into 2 subgroups: patients of subgroups 1A, 2A, and 3A were prescribed Cortexin in addition to standard therapy in accordance with current clinical guidelines.
    Summary · context
    Patients in subgroups 1B, 2B, and 3B received only standard therapy.
  4. 04HumanRandomized controlled trialMechanism

    In infants with severe perinatal CNS damage, adjunctive Cortexin reduced TNF-α more than standard therapy alone.

    In plain wordsIn infants with severe perinatal brain damage, added Cortexin reduced TNF-α more than standard therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseSerum TNF-α in severe perinatal CNS damage
    Study

    n = 50

    Comparator
    standard therapy alone in the same severity group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    TNF-α decrease
    1.4 fold
    subgroup 1A after treatment

    Source sentences

    Summary
    In subgroup 1A, the concentration of IL-Iß decreased by 1.5 times after treatment (p=0.022), and TNF-α by 1.4 times (p=0.033), which was statistically significantly higher than the similar changes in subgroup 1B.
    4 context sentences
    Summary · context
    146 children (86 boys, 60 girls) aged from 20 days to 6 months (the average age of boys was 2.7±1.2, and girls 2.9±1.1 months) with CNS PP were examined.
    Summary · context
    Depending on the severity of CNS PP, patients were divided into 3 groups: the 1st (n=50) included patients with severe CNS PP, the 2nd (n=58) - moderate and the 3rd (n=38) - with mild severity.
    Summary · context
    By random sampling, each group was divided into 2 subgroups: patients of subgroups 1A, 2A, and 3A were prescribed Cortexin in addition to standard therapy in accordance with current clinical guidelines.
    Summary · context
    Patients in subgroups 1B, 2B, and 3B received only standard therapy.
  5. 05HumanRandomized controlled trialMechanism

    In infants with mild perinatal CNS damage, IL-Iß showed a more favorable trend with adjunctive Cortexin than with standard therapy alone.

    In plain wordsIn infants with mild perinatal brain damage, IL-Iß trends were more favorable with added Cortexin than with standard therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedSerum IL-Iß trend in mild perinatal CNS damage
    Study

    n = 38

    Comparator
    standard therapy alone in the same severity group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In subgroup 3A, the dynamics of IL-Iß and TNF-α concentrations had a positive trend and exceeded similar indicators in subgroup 3B.
    4 context sentences
    Summary · context
    146 children (86 boys, 60 girls) aged from 20 days to 6 months (the average age of boys was 2.7±1.2, and girls 2.9±1.1 months) with CNS PP were examined.
    Summary · context
    Depending on the severity of CNS PP, patients were divided into 3 groups: the 1st (n=50) included patients with severe CNS PP, the 2nd (n=58) - moderate and the 3rd (n=38) - with mild severity.
    Summary · context
    By random sampling, each group was divided into 2 subgroups: patients of subgroups 1A, 2A, and 3A were prescribed Cortexin in addition to standard therapy in accordance with current clinical guidelines.
    Summary · context
    Patients in subgroups 1B, 2B, and 3B received only standard therapy.
  6. 06HumanRandomized controlled trialMechanism

    In infants with mild perinatal CNS damage, TNF-α showed a more favorable trend with adjunctive Cortexin than with standard therapy alone.

    In plain wordsIn infants with mild perinatal brain damage, TNF-α trends were more favorable with added Cortexin than with standard therapy alone.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Direction not reportedSerum TNF-α trend in mild perinatal CNS damage
    Study

    n = 38

    Comparator
    standard therapy alone in the same severity group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In subgroup 3A, the dynamics of IL-Iß and TNF-α concentrations had a positive trend and exceeded similar indicators in subgroup 3B.
    4 context sentences
    Summary · context
    146 children (86 boys, 60 girls) aged from 20 days to 6 months (the average age of boys was 2.7±1.2, and girls 2.9±1.1 months) with CNS PP were examined.
    Summary · context
    Depending on the severity of CNS PP, patients were divided into 3 groups: the 1st (n=50) included patients with severe CNS PP, the 2nd (n=58) - moderate and the 3rd (n=38) - with mild severity.
    Summary · context
    By random sampling, each group was divided into 2 subgroups: patients of subgroups 1A, 2A, and 3A were prescribed Cortexin in addition to standard therapy in accordance with current clinical guidelines.
    Summary · context
    Patients in subgroups 1B, 2B, and 3B received only standard therapy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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