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Study · Not a test of the peptide alone · 2025

2 results

Humanin variants aggregate to produce different fibril morphologies.

Morris DL, Nyenhuis SB, Gruschus JM, Nyenhuis DA, Puja R, Hinshaw JE, Tjandra N

The Journal of biological chemistry19 Jun 2025Cited by 1 (Europe PMC)

PMID40543583 (opens in a new tab)PMCIDPMC12281593 (opens in a new tab)DOI10.1016/j.jbc.2025.110403 (opens in a new tab)PepBankPUB-40543583
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    In cell-free biophysical tests, Humanin formed amyloid-like beta-sheet fibrils with defined secondary structure.

    In plain wordsIn lab tests, Humanin formed fibre-like structures with a beta-sheet shape.

    Peptide
    Humanin
    Outcome
    Not applicableAmyloid-like beta-sheet fibrillization of Humanin
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    the amyloid-like β-sheet fibrillization of HN along with characterization of its secondary structure properties via transmission electron microscopy and other biophysical techniques

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    In cell-free tests, Humanin mutants changed the fibrillization process, and mutants with inhibited beta-sheet fibrillization matched those previously identified as secretion deficient in vitro.

    In plain wordsIn lab tests, changes to the Humanin sequence altered fibre formation. Mutants that formed fewer fibres matched those not secreted from cells.

    Peptide
    Humanin
    Outcome
    Not applicableEffect of Humanin mutants on fibrillization
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    We identified several important HN mutants and documented their effects on the fibrillization process.
    1 context sentence
    Summary · context
    Mutants that display inhibited β-sheet fibrillization were associated with those previously identified to be secretion deficient in vitro, highlighting the importance of β-sheet structure for membrane interactions.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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