Effects of Kisspeptin on rabbit ovulation: a comprehensive study of ovulatory, endocrine and histological response.

Gimeno-Martos S, Gómez-León A, Luigia B, Lorenzo PL, María AÁ, Rosa María GG, Rebollar PG

Theriogenology6 Jun 2025

PMID40505597DOI10.1016/j.theriogenology.2025.117524PepBankPUB-40505597

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbit does, Kp10 induced ovulation in 87.5 % of animals, matching the response in the gonadorelin group.
In plain wordsIn female rabbits, kisspeptin‑10 triggered ovulation in most animals, about as often as the standard drug gonadorelin.
Peptide
Kisspeptin-10
Outcome
No significant changeOvulation rate
Study
rabbitn: not reported in source
multiparous New Zealand White x California does
Comparator
Gonadorelin (GnRH analogue)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
250 ug · intravenousAs given in this study (rabbit).
Measurements
Ovulation rate
87.5%
Kp10 group
Source sentences
Summary
Kp10 induced ovulation in 87.5 % of does, matching the response observed in the GnRH group, with a comparable number of corpora lutea (CL) per ovulated doe (12.9 ± 1.4 vs 14.6 ± 1.4 CL/doe, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
Multiparous New Zealand White × California does were assigned to three groups: control group (0.5 % saline solution, i.v.), GnRH group (20 μg gonadorelin, i.m.), and Kp10 group (250 μg Kp10, i.v.).
Report a problemFND-4050559701
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbit does, the number of corpora lutea per ovulated doe was comparable between Kp10 (12.9) and gonadorelin (14.6).
In plain wordsIn female rabbits, kisspeptin‑10 and gonadorelin gave a similar number of corpora lutea per ovulated animal.
Peptide
Kisspeptin-10
Outcome
No significant changeCorpora lutea per ovulated doe
Study
rabbitn: not reported in source
multiparous New Zealand White x California does
Comparator
Gonadorelin (GnRH analogue)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
250 ug · intravenousAs given in this study (rabbit).
Measurements
Corpora lutea per ovulated doe
12.9 CL/doe
Kp10 group
Corpora lutea per ovulated doe
14.6 CL/doe
GnRH group
Source sentences
Summary
Kp10 induced ovulation in 87.5 % of does, matching the response observed in the GnRH group, with a comparable number of corpora lutea (CL) per ovulated doe (12.9 ± 1.4 vs 14.6 ± 1.4 CL/doe, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
Multiparous New Zealand White × California does were assigned to three groups: control group (0.5 % saline solution, i.v.), GnRH group (20 μg gonadorelin, i.m.), and Kp10 group (250 μg Kp10, i.v.).
Report a problemFND-4050559702
03AnimalAnimal study (in vivo)Efficacy outcome
In rabbit does, plasma progesterone on day 7 was significantly lower in ovulated Kp10-treated does than in ovulated GnRH-treated does.
In plain wordsIn female rabbits, progesterone a week later was lower after kisspeptin‑10 than after gonadorelin.
Peptide
Kisspeptin-10
Outcome
DecreasePlasma progesterone on day 7
Study
rabbitn: not reported in source
multiparous New Zealand White x California does
Comparator
Gonadorelin (GnRH analogue)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
250 ug · intravenousAs given in this study (rabbit).
Measurements
Plasma progesterone day 7
9.47 ng/mL
Kp10-treated ovulated does
Plasma progesterone day 7
25.12 ng/mL
GnRH-treated ovulated does
Source sentences
Summary
On day 7, plasma progesterone (P4) was significantly higher in ovulated GnRH-treated does than in Kp10-treated ones (25.12 ± 4.17 vs 9.47 ± 4.17 ng/mL; p < 0.0211)
1 context sentence(design, population, supporting numbers)
Summary · context
Multiparous New Zealand White × California does were assigned to three groups: control group (0.5 % saline solution, i.v.), GnRH group (20 μg gonadorelin, i.m.), and Kp10 group (250 μg Kp10, i.v.).
Report a problemFND-4050559703
04AnimalAnimal study (in vivo)Efficacy outcome
In rabbit does, plasma estradiol showed no significant differences across days or groups.
In plain wordsIn female rabbits, estradiol did not differ significantly between days or between groups.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma estradiol
Study
rabbitn: not reported in source
multiparous New Zealand White x California does
Comparator
Gonadorelin (GnRH analogue)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
250 ug · intravenousAs given in this study (rabbit).
Source sentences
Summary
Plasma estradiol (E2) levels showed no significant differences across days or groups, with mean values of 32.74 ± 4.33 pg/mL on day 0 and 37.27 ± 5.49 pg/mL on day 7, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Multiparous New Zealand White × California does were assigned to three groups: control group (0.5 % saline solution, i.v.), GnRH group (20 μg gonadorelin, i.m.), and Kp10 group (250 μg Kp10, i.v.).
Report a problemFND-4050559704
05AnimalAnimal study (in vivo)Efficacy outcome
In rabbit does, Kp10 promoted preovulatory follicle development, mirroring GnRH effects.
In plain wordsIn female rabbits, kisspeptin‑10 helped follicles develop before ovulation, as gonadorelin did.
Peptide
Kisspeptin-10
Outcome
IncreasePreovulatory follicle development
Study
rabbitn: not reported in source
multiparous New Zealand White x California does
Comparator
Gonadorelin (GnRH analogue)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
250 ug · intravenousAs given in this study (rabbit).
Source sentences
Summary
Histological analysis confirmed that Kp10 promoted preovulatory follicle development and CL formation, mirroring GnRH effects.
1 context sentence(design, population, supporting numbers)
Summary · context
Multiparous New Zealand White × California does were assigned to three groups: control group (0.5 % saline solution, i.v.), GnRH group (20 μg gonadorelin, i.m.), and Kp10 group (250 μg Kp10, i.v.).
Report a problemFND-4050559705
06AnimalAnimal study (in vivo)Efficacy outcome
In rabbit does, Kp10 promoted corpus luteum formation, mirroring GnRH effects.
In plain wordsIn female rabbits, kisspeptin‑10 helped corpora lutea form, as gonadorelin did.
Peptide
Kisspeptin-10
Outcome
IncreaseCorpus luteum formation
Study
rabbitn: not reported in source
multiparous New Zealand White x California does
Comparator
Gonadorelin (GnRH analogue)
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
250 ug · intravenousAs given in this study (rabbit).
Source sentences
Summary
Histological analysis confirmed that Kp10 promoted preovulatory follicle development and CL formation, mirroring GnRH effects.
1 context sentence(design, population, supporting numbers)
Summary · context
Multiparous New Zealand White × California does were assigned to three groups: control group (0.5 % saline solution, i.v.), GnRH group (20 μg gonadorelin, i.m.), and Kp10 group (250 μg Kp10, i.v.).
Report a problemFND-4050559706
07AnimalAnimal study (in vivo)Mechanism
In rabbit does, Kp10 increased vascular endothelial growth factor expression in more developed follicles and corpora lutea.
In plain wordsIn female rabbits, kisspeptin‑10 raised the blood-vessel growth factor VEGF in more developed follicles and corpora lutea.
Peptide
Kisspeptin-10
Outcome
IncreaseVEGF expression in follicles and corpora lutea
Study
rabbitn: not reported in source
multiparous New Zealand White x California does
Comparator
Gonadorelin (GnRH analogue)
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
250 ug · intravenousAs given in this study (rabbit).
Source sentences
Summary
Additionally, Kp10 enhanced angiogenesis, indicated by increased vascular endothelial growth factor (VEGF) expression in more developed follicles and CL.
1 context sentence(design, population, supporting numbers)
Summary · context
Multiparous New Zealand White × California does were assigned to three groups: control group (0.5 % saline solution, i.v.), GnRH group (20 μg gonadorelin, i.m.), and Kp10 group (250 μg Kp10, i.v.).
Report a problemFND-4050559707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Journal Article

MeSH terms

Keywords

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