The safety and efficacy of liraglutide combined with metformin in clinical treatment of polycystic ovary syndrome patients: a meta-analysis.

Huang R, He Y

BMC women's health6 Jun 2025Cited by 1 (Europe PMC)

PMID40481408PMCIDPMC12143058DOI10.1186/s12905-025-03787-zPepBankPUB-40481408

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

01HumanSystematic reviewEfficacy outcome
In patients with polycystic ovary syndrome, adding liraglutide to metformin was superior to metformin alone for body mass index; the outcome-specific coefficient and analyzed N were unstated.
In plain wordsIn people with PCOS, adding liraglutide to metformin was superior to metformin alone for body mass index.
Peptide
Liraglutide
Outcome
Direction not reportedBody mass index
Study
n: not reported in source
Comparator
metformin alone
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
The meta-analysis revealed that the group receiving metformin combined with liraglutide demonstrated superiority over the group receiving metformin alone in terms of body mass index (BMI), glucose levels, lipid levels, hormone levels, establishment of menstrual cycles, normal ovulation rate, and rat…
3 context sentences(design, population, supporting numbers)
Summary · context
This study aims to investigate the effectiveness and safety of the combination of liraglutide and metformin for clinical treatment of patients with polycystic ovary syndrome.
Summary · context
Computerized searches were performed on PubMed, Embase, Web of Science, The Cochrane Library, CNKI, CBM, Wanfang, and VIP databases to collect randomized controlled trials(RCT) on the efficacy of metformin and liraglutide in the treatment of polycystic ovary syndrome.
Summary · context
The search period spanned from the inception of the databases to August 2024.
Report a problemFND-4048140801
02HumanSystematic reviewEfficacy outcome
In patients with polycystic ovary syndrome, adding liraglutide to metformin was superior to metformin alone for glucose levels; the outcome-specific coefficient and analyzed N were unstated.
In plain wordsIn people with PCOS, adding liraglutide to metformin was superior to metformin alone for glucose levels.
Peptide
Liraglutide
Outcome
Direction not reportedGlucose levels
Study
n: not reported in source
Comparator
metformin alone
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
The meta-analysis revealed that the group receiving metformin combined with liraglutide demonstrated superiority over the group receiving metformin alone in terms of body mass index (BMI), glucose levels, lipid levels, hormone levels, establishment of menstrual cycles, normal ovulation rate, and rat…
3 context sentences(design, population, supporting numbers)
Summary · context
This study aims to investigate the effectiveness and safety of the combination of liraglutide and metformin for clinical treatment of patients with polycystic ovary syndrome.
Summary · context
Computerized searches were performed on PubMed, Embase, Web of Science, The Cochrane Library, CNKI, CBM, Wanfang, and VIP databases to collect randomized controlled trials(RCT) on the efficacy of metformin and liraglutide in the treatment of polycystic ovary syndrome.
Summary · context
The search period spanned from the inception of the databases to August 2024.
Report a problemFND-4048140802
03HumanSystematic reviewEfficacy outcome
In patients with polycystic ovary syndrome, adding liraglutide to metformin was superior to metformin alone for lipid levels; the outcome-specific coefficient and analyzed N were unstated.
In plain wordsIn people with PCOS, adding liraglutide to metformin was superior to metformin alone for lipid levels.
Peptide
Liraglutide
Outcome
Direction not reportedLipid levels
Study
n: not reported in source
Comparator
metformin alone
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
The meta-analysis revealed that the group receiving metformin combined with liraglutide demonstrated superiority over the group receiving metformin alone in terms of body mass index (BMI), glucose levels, lipid levels, hormone levels, establishment of menstrual cycles, normal ovulation rate, and rat…
3 context sentences(design, population, supporting numbers)
Summary · context
This study aims to investigate the effectiveness and safety of the combination of liraglutide and metformin for clinical treatment of patients with polycystic ovary syndrome.
Summary · context
Computerized searches were performed on PubMed, Embase, Web of Science, The Cochrane Library, CNKI, CBM, Wanfang, and VIP databases to collect randomized controlled trials(RCT) on the efficacy of metformin and liraglutide in the treatment of polycystic ovary syndrome.
Summary · context
The search period spanned from the inception of the databases to August 2024.
Report a problemFND-4048140803
04HumanSystematic reviewEfficacy outcome
In patients with polycystic ovary syndrome, adding liraglutide to metformin was superior to metformin alone for hormone levels; the outcome-specific coefficient and analyzed N were unstated.
In plain wordsIn people with polycystic ovary syndrome, metformin plus liraglutide was superior to metformin alone for hormone levels.
Peptide
Liraglutide
Outcome
Direction not reportedHormone levels
Study
n: not reported in source
Comparator
metformin alone
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The meta-analysis revealed that the group receiving metformin combined with liraglutide demonstrated superiority over the group receiving metformin alone in terms of body mass index (BMI), glucose levels, lipid levels, hormone levels, establishment of menstrual cycles, normal ovulation rate, and rat…
3 context sentences(design, population, supporting numbers)
Summary · context
This study aims to investigate the effectiveness and safety of the combination of liraglutide and metformin for clinical treatment of patients with polycystic ovary syndrome.
Summary · context
Computerized searches were performed on PubMed, Embase, Web of Science, The Cochrane Library, CNKI, CBM, Wanfang, and VIP databases to collect randomized controlled trials(RCT) on the efficacy of metformin and liraglutide in the treatment of polycystic ovary syndrome.
Summary · context
The search period spanned from the inception of the databases to August 2024.
Report a problemFND-4048140804
05HumanSystematic reviewEfficacy outcome
In patients with polycystic ovary syndrome, adding liraglutide to metformin was superior to metformin alone for establishment of menstrual cycles; the outcome-specific coefficient and analyzed N were unstated.
In plain wordsIn people with polycystic ovary syndrome, metformin plus liraglutide was superior to metformin alone for menstrual cycle establishment.
Peptide
Liraglutide
Outcome
Direction not reportedMenstrual cycle establishment
Study
n: not reported in source
Comparator
metformin alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The meta-analysis revealed that the group receiving metformin combined with liraglutide demonstrated superiority over the group receiving metformin alone in terms of body mass index (BMI), glucose levels, lipid levels, hormone levels, establishment of menstrual cycles, normal ovulation rate, and rat…
3 context sentences(design, population, supporting numbers)
Summary · context
This study aims to investigate the effectiveness and safety of the combination of liraglutide and metformin for clinical treatment of patients with polycystic ovary syndrome.
Summary · context
Computerized searches were performed on PubMed, Embase, Web of Science, The Cochrane Library, CNKI, CBM, Wanfang, and VIP databases to collect randomized controlled trials(RCT) on the efficacy of metformin and liraglutide in the treatment of polycystic ovary syndrome.
Summary · context
The search period spanned from the inception of the databases to August 2024.
Report a problemFND-4048140805
06HumanSystematic reviewEfficacy outcome
In patients with polycystic ovary syndrome, adding liraglutide to metformin was superior to metformin alone for normal ovulation rate; the outcome-specific coefficient and analyzed N were unstated.
In plain wordsIn people with polycystic ovary syndrome, metformin plus liraglutide was superior to metformin alone for normal ovulation rate.
Peptide
Liraglutide
Outcome
Direction not reportedNormal ovulation rate
Study
n: not reported in source
Comparator
metformin alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The meta-analysis revealed that the group receiving metformin combined with liraglutide demonstrated superiority over the group receiving metformin alone in terms of body mass index (BMI), glucose levels, lipid levels, hormone levels, establishment of menstrual cycles, normal ovulation rate, and rat…
3 context sentences(design, population, supporting numbers)
Summary · context
This study aims to investigate the effectiveness and safety of the combination of liraglutide and metformin for clinical treatment of patients with polycystic ovary syndrome.
Summary · context
Computerized searches were performed on PubMed, Embase, Web of Science, The Cochrane Library, CNKI, CBM, Wanfang, and VIP databases to collect randomized controlled trials(RCT) on the efficacy of metformin and liraglutide in the treatment of polycystic ovary syndrome.
Summary · context
The search period spanned from the inception of the databases to August 2024.
Report a problemFND-4048140806
07HumanSystematic reviewEfficacy outcome
In patients with polycystic ovary syndrome, adding liraglutide to metformin was superior to metformin alone for spontaneous conception rate; the outcome-specific coefficient and analyzed N were unstated.
In plain wordsIn people with polycystic ovary syndrome, metformin plus liraglutide was superior to metformin alone for spontaneous conception rate.
Peptide
Liraglutide
Outcome
Direction not reportedSpontaneous conception rate
Study
n: not reported in source
Comparator
metformin alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The meta-analysis revealed that the group receiving metformin combined with liraglutide demonstrated superiority over the group receiving metformin alone in terms of body mass index (BMI), glucose levels, lipid levels, hormone levels, establishment of menstrual cycles, normal ovulation rate, and rat…
3 context sentences(design, population, supporting numbers)
Summary · context
This study aims to investigate the effectiveness and safety of the combination of liraglutide and metformin for clinical treatment of patients with polycystic ovary syndrome.
Summary · context
Computerized searches were performed on PubMed, Embase, Web of Science, The Cochrane Library, CNKI, CBM, Wanfang, and VIP databases to collect randomized controlled trials(RCT) on the efficacy of metformin and liraglutide in the treatment of polycystic ovary syndrome.
Summary · context
The search period spanned from the inception of the databases to August 2024.
Report a problemFND-4048140807
08HumanSystematic reviewSafety outcome
In patients with polycystic ovary syndrome, adding liraglutide to metformin had a higher incidence of gastrointestinal reactions than metformin alone; the outcome-specific coefficient and analyzed N were unstated.
In plain wordsIn people with polycystic ovary syndrome, metformin plus liraglutide had a higher incidence of gastrointestinal reactions than metformin alone.
Peptide
Liraglutide
Outcome
IncreaseGastrointestinal reactions
Study
n: not reported in source
Comparator
metformin alone
Outcome group
Gastrointestinal adverse events · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
However, the former group also exhibited a higher incidence of gastrointestinal reactions compared to the latter group.
4 context sentences(design, population, supporting numbers)
Summary · context
The meta-analysis revealed that the group receiving metformin combined with liraglutide demonstrated superiority over the group receiving metformin alone in terms of body mass index (BMI), glucose levels, lipid levels, hormone levels, establishment of menstrual cycles, normal ovulation rate, and rat…
Summary · context
This study aims to investigate the effectiveness and safety of the combination of liraglutide and metformin for clinical treatment of patients with polycystic ovary syndrome.
Summary · context
Computerized searches were performed on PubMed, Embase, Web of Science, The Cochrane Library, CNKI, CBM, Wanfang, and VIP databases to collect randomized controlled trials(RCT) on the efficacy of metformin and liraglutide in the treatment of polycystic ovary syndrome.
Summary · context
The search period spanned from the inception of the databases to August 2024.
Report a problemFND-4048140808

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 11:11 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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