Polyphosphate- and Antioxidant Peptide-Based Coacervate Delivers miRNA.

Wang C, Xu X, Dai S, Xie Z, Lu J, Wang B, Zhang F, Zhou R, Du Y, Tian B

ACS applied materials & interfaces6 Jun 2025Cited by 5 (Europe PMC)

PMID40478241DOI10.1021/acsami.5c00048PepBankPUB-40478241

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

01AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In mice with acute lung injury, intratracheal Coac@miR and intravenous EMCoac@miR (SS‑31 coacervates with miRNA-223) alleviated lung injury.
In plain wordsIn mice with lung injury, coacervate products carrying miRNA-223 and SS‑31 eased the injury. The effect is for the whole product.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseAcute lung injury
Study
mousen: not reported in source
acute lung injury model
Outcome group
Inflammation markers · Respiratory
Source sentences
Summary
With acute lung injury (ALI) mouse model, we find that both intratracheal injection (i.t.) of Coac@miR and intravenous injection (i.v.) of EMCoac@miR could alleviate ALI by reprogramming macrophages to an anti-inflammatory (M2) phenotype, inhibiting inflammatory factors, and relieving ROS stress.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we developed a type of coacervate droplet as the delivery vector formed by the LLPS of sodium hexametaphosphate (SHMP) and antioxidant peptide SS-31, followed by loading with microRNA-223 (miRNA-223) as a coacervate artificial cell (Coac@miR).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4047824102
02AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism
In mice with acute lung injury, SS‑31 coacervates with miRNA-223 reprogrammed macrophages to an anti-inflammatory M2 phenotype.
In plain wordsIn mice with lung injury, coacervate products carrying miRNA-223 and SS‑31 shifted macrophages to an anti-inflammatory type. The effect is for the whole product.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMacrophage polarisation to M2 phenotype
Study
mousen: not reported in source
acute lung injury model
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
With acute lung injury (ALI) mouse model, we find that both intratracheal injection (i.t.) of Coac@miR and intravenous injection (i.v.) of EMCoac@miR could alleviate ALI by reprogramming macrophages to an anti-inflammatory (M2) phenotype, inhibiting inflammatory factors, and relieving ROS stress.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we developed a type of coacervate droplet as the delivery vector formed by the LLPS of sodium hexametaphosphate (SHMP) and antioxidant peptide SS-31, followed by loading with microRNA-223 (miRNA-223) as a coacervate artificial cell (Coac@miR).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4047824103
03AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In mice with acute lung injury, SS‑31 coacervates with miRNA-223 inhibited inflammatory factors.
In plain wordsIn mice with lung injury, coacervate products carrying miRNA-223 and SS‑31 lowered inflammatory factors. The effect is for the whole product.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseInflammatory factors
Study
mousen: not reported in source
acute lung injury model
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
With acute lung injury (ALI) mouse model, we find that both intratracheal injection (i.t.) of Coac@miR and intravenous injection (i.v.) of EMCoac@miR could alleviate ALI by reprogramming macrophages to an anti-inflammatory (M2) phenotype, inhibiting inflammatory factors, and relieving ROS stress.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we developed a type of coacervate droplet as the delivery vector formed by the LLPS of sodium hexametaphosphate (SHMP) and antioxidant peptide SS-31, followed by loading with microRNA-223 (miRNA-223) as a coacervate artificial cell (Coac@miR).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4047824104
04AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In mice with acute lung injury, SS‑31 coacervates with miRNA-223 relieved ROS stress.
In plain wordsIn mice with lung injury, coacervate products carrying miRNA-223 and SS‑31 eased oxidative stress. The effect is for the whole product.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseROS stress
Study
mousen: not reported in source
acute lung injury model
Outcome group
Oxidative stress · Respiratory
Source sentences
Summary
With acute lung injury (ALI) mouse model, we find that both intratracheal injection (i.t.) of Coac@miR and intravenous injection (i.v.) of EMCoac@miR could alleviate ALI by reprogramming macrophages to an anti-inflammatory (M2) phenotype, inhibiting inflammatory factors, and relieving ROS stress.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we developed a type of coacervate droplet as the delivery vector formed by the LLPS of sodium hexametaphosphate (SHMP) and antioxidant peptide SS-31, followed by loading with microRNA-223 (miRNA-223) as a coacervate artificial cell (Coac@miR).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4047824105
05LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Activity measurement
SS‑31 and polyphosphate coacervate artificial cells loaded with miRNA-223 raised the cytoplasmic delivery efficiency of miRNA-223 10-fold compared with miRNA-223 alone.
In plain wordsIn lab tests, a coacervate carrying miRNA-223 delivered 10-fold more miRNA into cells than miRNA alone. The coacervate contains SS‑31 and other parts.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseCytoplasmic delivery efficiency of miRNA-223
Study
n: not reported in source
coacervate artificial cells
Comparator
miRNA-223 alone
Outcome group
Formulation, delivery and stability · Pharmacology
Measurements
cytoplasmic delivery efficiency
10 fold
versus miRNA-223 alone
Source sentences
Summary
The coacervate artificial cells demonstrate increased cytoplasmic delivery efficiency of miRNA-223 by 10-fold higher than the miRNA-223 alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we developed a type of coacervate droplet as the delivery vector formed by the LLPS of sodium hexametaphosphate (SHMP) and antioxidant peptide SS-31, followed by loading with microRNA-223 (miRNA-223) as a coacervate artificial cell (Coac@miR).
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-4047824101

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

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Journal Article

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