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Study · Animal study (in vivo) · mouse · 2025

7 results

Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice.

Hiroshige S, Kajimura Y, Nagao Y, Taguchi A, Hatanaka R, Yodokawa C, Fujioka Y, Akiyama M, Tanizawa Y, Ohta Y

Endocrine journal3 Jun 2025

PMID40467473 (opens in a new tab)PMCIDPMC12436074 (opens in a new tab)DOI10.1507/endocrj.ej24-0312 (opens in a new tab)PepBankPUB-40467473
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, NMN injection increased hepatic Sirt1 mRNA levels.

    In plain wordsIn mice, NMN injection increased Sirt1 gene expression in the liver.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseHepatic Sirt1 mRNA
    Study

    mousen: not reported in source

    mice
    Outcome group
    Energy expenditure and thermogenesis · Liver
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Sirt1 and Nampt mRNA levels were increased in the liver suggesting that intracellular NAD+ increased after injection.
    1 context sentence
    Summary · context
    We observed metabolic dynamics after a single bolus injection of NMN.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, NMN injection increased hepatic Nampt mRNA levels.

    In plain wordsIn mice, NMN injection increased Nampt gene expression in the liver.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseHepatic Nampt mRNA
    Study

    mousen: not reported in source

    mice
    Outcome group
    Energy expenditure and thermogenesis · Liver
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Sirt1 and Nampt mRNA levels were increased in the liver suggesting that intracellular NAD+ increased after injection.
    1 context sentence
    Summary · context
    We observed metabolic dynamics after a single bolus injection of NMN.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN did not significantly change glucose tolerance during OGTT.

    In plain wordsIn mice, NMN did not significantly change glucose tolerance during an oral glucose test.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeGlucose tolerance during OGTT
    Study

    mousen: not reported in source

    mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    During OGTT, glucose tolerance and insulin secretion did not change significantly in response to NMN administration, while during ITT, increased insulin sensitivity was observed in muscle.
    1 context sentence
    Summary · context
    We observed metabolic dynamics after a single bolus injection of NMN.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN did not significantly change insulin secretion during OGTT.

    In plain wordsIn mice, NMN did not significantly change insulin release during an oral glucose test.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeInsulin secretion during OGTT
    Study

    mousen: not reported in source

    mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    During OGTT, glucose tolerance and insulin secretion did not change significantly in response to NMN administration, while during ITT, increased insulin sensitivity was observed in muscle.
    1 context sentence
    Summary · context
    We observed metabolic dynamics after a single bolus injection of NMN.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN increased muscle insulin sensitivity during ITT.

    In plain wordsIn mice, NMN increased muscle sensitivity to insulin during an insulin tolerance test.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMuscle insulin sensitivity during ITT
    Study

    mousen: not reported in source

    mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    During OGTT, glucose tolerance and insulin secretion did not change significantly in response to NMN administration, while during ITT, increased insulin sensitivity was observed in muscle.
    1 context sentence
    Summary · context
    We observed metabolic dynamics after a single bolus injection of NMN.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN reduced serum non-esterified free fatty acid concentrations.

    In plain wordsIn mice, NMN reduced free fatty acids in blood.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSerum non-esterified free fatty acids
    Study

    mousen: not reported in source

    mice
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    NMN administration decreased serum non-esterified free fatty acid (NEFA) concentrations, which would presumably be responsible for the increased muscle insulin sensitivity.
    1 context sentence
    Summary · context
    We observed metabolic dynamics after a single bolus injection of NMN.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN reduced the respiratory quotient.

    In plain wordsIn mice, NMN reduced the respiratory quotient, consistent with greater fat use for energy.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseRespiratory quotient
    Study

    mousen: not reported in source

    mice
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, NMN administration reduced the respiratory quotient, confirming that NMN promotes utilization of lipids as an energy source.
    1 context sentence
    Summary · context
    We observed metabolic dynamics after a single bolus injection of NMN.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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