In pooled human hepatocytes incubated with alexamorelin for 3 h, the only metabolite detected was examorelin (hexarelin), from C-terminal cleavage of Ala.
In plain wordsIn lab tests with human liver cells, alexamorelin broke down into hexarelin (examorelin) as the only metabolite found after 3 hours.
- Peptide
- Hexarelin
- Outcome
- Not applicableMetabolite detected after 3 h hepatocyte incubation of alexamorelin
- Study
humann: not reported in source
Pooled human hepatocytes from 10 donors- Outcome group
- Pharmacokinetics · Pharmacology
Source sentences
After 3 h of incubation with hepatocytes, only one metabolite (known as examorelin or hexarelin) was detected, resulting from the C-terminal cleavage of the Ala amino acid; this metabolic reaction is mediated by a carboxypeptidase.
1 context sentence(design, population, supporting numbers)
In silico metabolite predictions were performed using GLORYx freeware, and in vitro incubations were conducted with pooled human hepatocytes from 10 donors.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.