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Study · Case report or series · n = 1 · 2025

1 result

Echoes of Dormancy: Anomic Aphasia Unveils Neurocysticercosis Reactivation in a Patient on Semaglutide.

Osorio Borjas M, Hernandez RJ, Lopez-Lacayo A, Laffita Perez D, Oliva Y, Mercado J, Hussain H

NeuroSci5 May 2025Cited by 1 (Europe PMC)

PMID40407613 (opens in a new tab)PMCIDPMC12101238 (opens in a new tab)DOI10.3390/neurosci6020040 (opens in a new tab)PepBankPUB-40407613
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Summary

Neurocysticercosis (NCC), a parasitic infection caused by Taenia solium larvae, remains a leading cause of acquired epilepsy worldwide, particularly in regions with inadequate sanitation and healthcare access. We present a case of NCC reactivation in a 64-year-old female who developed anomic aphasia-a rare manifestation of NCC-decades after her initial diagnosis. The patient's clinical course was complicated by a potential trigger of semaglutide, which potentially attenuated the protective inflammatory response maintained by astrocytes and microglia, leading to the reactivation of dormant cysts. Brain imaging confirmed localized cystic changes, and treatment with antiparasitic agents and corticosteroids led to marked clinical improvement. This case highlights the complexity of NCC reactivation, highlighting the interplay of metabolic, immune, and parasitic factors. It emphasizes the need for vigilance in managing patients with dormant infections and investigating potential risks associated with novel therapeutic agents like GLP-1 receptor agonists. Further research is essential to unravel the mechanisms linking metabolic modulation to parasitic reactivation, offering insights into prevention and treatment strategies.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanCase report or seriesSafety outcome

    In a 64-year-old woman, neurocysticercosis reactivated with anomic aphasia during semaglutide use; the authors suggest semaglutide as a potential trigger.

    In plain wordsIn one 64-year-old woman, a dormant brain parasite infection reactivated during semaglutide use. The authors say semaglutide may have been a trigger.

    Peptide
    Semaglutide
    Outcome
    IncreaseNeurocysticercosis reactivation during semaglutide use
    Study

    n = 1

    Outcome group
    Adverse events · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The patient's clinical course was complicated by a potential trigger of semaglutide, which potentially attenuated the protective inflammatory response maintained by astrocytes and microglia, leading to the reactivation of dormant cysts.
    1 context sentence
    Summary · context
    We present a case of NCC reactivation in a 64-year-old female who developed anomic aphasia-a rare manifestation of NCC-decades after her initial diagnosis.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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