Neurotropic Effects of Cortexin on Models of Mental and Physical Developmental Delay.

Kurkin DV, Bakulin DA, Morkovin EI, Petrov VI, Strygin AV, Smirnov AV, Shmidt MV, Gorbunova JV, Kolosov YA, Ivanova OV, Krysanov IS, Dzhavakhyan MA and 7 more

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Zaborovsky AV, Saparova VB, Makarenko IE, Drai RI, Lugovik IA, Verlov NA, Burdakov VS

Biomedicines2 Apr 2025

PMID40299434PMCIDPMC12024793DOI10.3390/biomedicines13040860PepBankPUB-40299434

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Summary

Objective: To evaluate the efficacy of the neurotropic action of cortexin in models of mental and physical developmental delays in rat offspring. Methods: The neurotropic properties of bovine brain cortex polypeptides were studied using two models of mental and physical developmental delays in rats: toxic CNS damage (oral administration of ethanol during the last week of pregnancy) and neonatal trauma (ischemia-hypoxia). The drug was administered intramuscularly or rectally as suppositories for 20 days. Treatment efficacy was evaluated using the mNSS scale, open field, rotarod, and adhesive removal tests. A histological examination of the brain was subsequently performed. In a separate series of experiments in mice, the concentration of the test drug cortexin and the reference drug cerebrolysin was determined in blood and brain tissue samples using radioactive iodine (Na125I) labeling of these preparations. Results: Modeling developmental delay in rat offspring (due to the toxic effect of ethanol in late pregnancy or neonatal trauma) led to pronounced neurological deficits, manifested by decreased motor activity, and sensorimotor, and coordination disorders. Administration of cortexin in all forms reduced the severity of neurological deficits as measured by mNSS scores, improved motor activity in the Open Field test, enhanced performance in the Adhesive Removal and Rotarod tests, and decreased structural changes in brain tissues. Histological examination revealed reduced neuronal damage in multiple cortical regions, with a significant increase in normal, unchanged neurons compared to placebo groups. Comparison of the blood concentrations of labeled Na125I cortexin depending on the type of administration showed similar distribution profiles in brain tissues, primarily dependent on its blood concentration, which was influenced by the route of administration. Conclusions: The results indicate that brain polypeptides (cortexin), administered either intramuscularly or rectally, can reach the systemic circulation and cross the blood-brain barrier, as demonstrated by our distribution studies using radiolabeled preparations. These polypeptides exert comparable neurotropic effects in models of mental and physical developmental delays in offspring caused by neonatal trauma or the toxic effect of ethanol in late pregnancy in rats.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rat offspring with developmental delay, Cortexin reduced neurological deficits measured by mNSS.
In plain wordsIn rats with developmental delay, Cortexin reduced neurological deficits.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreasemNSS neurological deficit
Study
ratn: not reported in source
Developmental delay after prenatal ethanol or neonatal ischemia-hypoxia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intramuscular or rectal · 20 daysAs given in this study (rat).
Source sentences
Summary
Administration of cortexin in all forms reduced the severity of neurological deficits as measured by mNSS scores, improved motor activity in the Open Field test, enhanced performance in the Adhesive Removal and Rotarod tests, and decreased structural changes in brain tissues.
2 context sentences(design, population, supporting numbers)
Summary · context
The neurotropic properties of bovine brain cortex polypeptides were studied using two models of mental and physical developmental delays in rats: toxic CNS damage (oral administration of ethanol during the last week of pregnancy) and neonatal trauma (ischemia-hypoxia).
Summary · context
The drug was administered intramuscularly or rectally as suppositories for 20 days.
Show in the study text Report a problemFND-4029943401
02AnimalAnimal study (in vivo)Efficacy outcome
In rat offspring with developmental delay, Cortexin improved motor activity in the Open Field test.
In plain wordsIn rats with developmental delay, Cortexin improved movement in the Open Field test.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseOpen Field motor activity
Study
ratn: not reported in source
Developmental delay after prenatal ethanol or neonatal ischemia-hypoxia
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · intramuscular or rectal · 20 daysAs given in this study (rat).
Source sentences
Summary
Administration of cortexin in all forms reduced the severity of neurological deficits as measured by mNSS scores, improved motor activity in the Open Field test, enhanced performance in the Adhesive Removal and Rotarod tests, and decreased structural changes in brain tissues.
2 context sentences(design, population, supporting numbers)
Summary · context
The neurotropic properties of bovine brain cortex polypeptides were studied using two models of mental and physical developmental delays in rats: toxic CNS damage (oral administration of ethanol during the last week of pregnancy) and neonatal trauma (ischemia-hypoxia).
Summary · context
The drug was administered intramuscularly or rectally as suppositories for 20 days.
Show in the study text Report a problemFND-4029943402
03AnimalAnimal study (in vivo)Efficacy outcome
In rat offspring with developmental delay, Cortexin improved Adhesive Removal test performance.
In plain wordsIn rats with developmental delay, Cortexin improved performance in the Adhesive Removal test.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseAdhesive Removal performance
Study
ratn: not reported in source
Developmental delay after prenatal ethanol or neonatal ischemia-hypoxia
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · intramuscular or rectal · 20 daysAs given in this study (rat).
Source sentences
Summary
Administration of cortexin in all forms reduced the severity of neurological deficits as measured by mNSS scores, improved motor activity in the Open Field test, enhanced performance in the Adhesive Removal and Rotarod tests, and decreased structural changes in brain tissues.
2 context sentences(design, population, supporting numbers)
Summary · context
The neurotropic properties of bovine brain cortex polypeptides were studied using two models of mental and physical developmental delays in rats: toxic CNS damage (oral administration of ethanol during the last week of pregnancy) and neonatal trauma (ischemia-hypoxia).
Summary · context
The drug was administered intramuscularly or rectally as suppositories for 20 days.
Show in the study text Report a problemFND-4029943403
04AnimalAnimal study (in vivo)Efficacy outcome
In rat offspring with developmental delay, Cortexin improved Rotarod performance.
In plain wordsIn rats with developmental delay, Cortexin improved Rotarod performance.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseRotarod performance
Study
ratn: not reported in source
Developmental delay after prenatal ethanol or neonatal ischemia-hypoxia
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · intramuscular or rectal · 20 daysAs given in this study (rat).
Source sentences
Summary
Administration of cortexin in all forms reduced the severity of neurological deficits as measured by mNSS scores, improved motor activity in the Open Field test, enhanced performance in the Adhesive Removal and Rotarod tests, and decreased structural changes in brain tissues.
2 context sentences(design, population, supporting numbers)
Summary · context
The neurotropic properties of bovine brain cortex polypeptides were studied using two models of mental and physical developmental delays in rats: toxic CNS damage (oral administration of ethanol during the last week of pregnancy) and neonatal trauma (ischemia-hypoxia).
Summary · context
The drug was administered intramuscularly or rectally as suppositories for 20 days.
Show in the study text Report a problemFND-4029943404
05AnimalAnimal study (in vivo)Efficacy outcome
In rat offspring with developmental delay, Cortexin decreased structural changes in brain tissue.
In plain wordsIn rats with developmental delay, Cortexin reduced structural brain changes.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseStructural brain changes
Study
ratn: not reported in source
Developmental delay after prenatal ethanol or neonatal ischemia-hypoxia
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intramuscular or rectal · 20 daysAs given in this study (rat).
Source sentences
Summary
Administration of cortexin in all forms reduced the severity of neurological deficits as measured by mNSS scores, improved motor activity in the Open Field test, enhanced performance in the Adhesive Removal and Rotarod tests, and decreased structural changes in brain tissues.
2 context sentences(design, population, supporting numbers)
Summary · context
The neurotropic properties of bovine brain cortex polypeptides were studied using two models of mental and physical developmental delays in rats: toxic CNS damage (oral administration of ethanol during the last week of pregnancy) and neonatal trauma (ischemia-hypoxia).
Summary · context
The drug was administered intramuscularly or rectally as suppositories for 20 days.
Show in the study text Report a problemFND-4029943405
06AnimalAnimal study (in vivo)Efficacy outcome
In rat offspring with developmental delay, Cortexin reduced neuronal damage in multiple cortical regions versus placebo.
In plain wordsIn rats with developmental delay, Cortexin reduced damage to cortical neurons versus placebo.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseNeuronal damage
Study
ratn: not reported in source
Developmental delay after prenatal ethanol or neonatal ischemia-hypoxia
Comparator
placebo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intramuscular or rectal · 20 daysAs given in this study (rat).
Source sentences
Summary
Histological examination revealed reduced neuronal damage in multiple cortical regions, with a significant increase in normal, unchanged neurons compared to placebo groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The neurotropic properties of bovine brain cortex polypeptides were studied using two models of mental and physical developmental delays in rats: toxic CNS damage (oral administration of ethanol during the last week of pregnancy) and neonatal trauma (ischemia-hypoxia).
Summary · context
The drug was administered intramuscularly or rectally as suppositories for 20 days.
Show in the study text Report a problemFND-4029943406
07AnimalAnimal study (in vivo)Efficacy outcome
In rat offspring with developmental delay, Cortexin significantly increased normal unchanged neurons versus placebo.
In plain wordsIn rats with developmental delay, Cortexin increased normal neurons versus placebo.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseNormal unchanged neurons
Study
ratn: not reported in source
Developmental delay after prenatal ethanol or neonatal ischemia-hypoxia
Comparator
placebo
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intramuscular or rectal · 20 daysAs given in this study (rat).
Source sentences
Summary
Histological examination revealed reduced neuronal damage in multiple cortical regions, with a significant increase in normal, unchanged neurons compared to placebo groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The neurotropic properties of bovine brain cortex polypeptides were studied using two models of mental and physical developmental delays in rats: toxic CNS damage (oral administration of ethanol during the last week of pregnancy) and neonatal trauma (ischemia-hypoxia).
Summary · context
The drug was administered intramuscularly or rectally as suppositories for 20 days.
Show in the study text Report a problemFND-4029943407

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 2
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Neurotropic Effects of Cortexin on Models of Mental and Physical Developmental Delay.

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Results from this study7

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