In adults with difficult-to-control type 2 diabetes, tirzepatide use was associated with a higher prevalence of hypercortisolism (odds ratio 1.981).
In plain wordsIn adults with hard-to-control type 2 diabetes, tirzepatide use was linked to more excess cortisol. This does not show tirzepatide caused it.
- Peptide
- Tirzepatide
- Outcome
- IncreaseAssociation of tirzepatide use with hypercortisolism prevalence
- Study
n = 1,057
- Outcome group
- Stress hormones · Endocrine and hormones
Measurements
- Odds ratio
- 1.981 ratio
- tirzepatide use
Source sentences
tirzepatide (1.981), or a higher number of blood pressure-lowering medications (1.390); older age (1.316); BMI <30 kg/m2 (1.639); non-Latino/Hispanic ethnicity (3.718); and use of fibrates (2.676) or analgesics (1.457) were associated with higher prevalence (all P < 0.03).
1 context sentence(design, population, supporting numbers)
Individuals with type 2 diabetes and HbA1c 7.5%-11.5% (58-102 mmol/mol) on two or more glucose-lowering medications with or without micro-/macrovascular complications or taking multiple blood pressure-lowering medications were screened with a 1-mg dexamethasone suppression test.
In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.