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Study · Animal study (in vivo) · mouse · 2025

7 results

NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal Barrier.

Liu S, Du N, Ge K, Hu J, Zhang W

Investigative ophthalmology & visual science1 Apr 2025Cited by 11 (Europe PMC)

PMID40249604 (opens in a new tab)PMCIDPMC12013676 (opens in a new tab)DOI10.1167/iovs.66.4.51 (opens in a new tab)PepBankPUB-40249604
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with high-altitude hypoxic barrier injury, NMN reduced endothelial cell apoptosis.

    In plain wordsIn mice with hypoxic retinal barrier injury, NMN reduced programmed endothelial cell death.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseEndothelial apoptosis
    Study

    mousen: not reported in source

    Simulated high-altitude BRB injury
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both in vitro and in vivo experiments showed that NMN intervention reduced endothelial cell apoptosis and permeability.
    1 context sentence
    Summary · context
    We established a mouse model of high-altitude BRB injury using a simulated high-altitude environment chamber.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with high-altitude hypoxic barrier injury, NMN reduced endothelial permeability.

    In plain wordsIn mice with hypoxic retinal barrier injury, NMN reduced endothelial permeability.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseEndothelial permeability
    Study

    mousen: not reported in source

    Simulated high-altitude BRB injury
    Outcome group
    Vascular function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both in vitro and in vivo experiments showed that NMN intervention reduced endothelial cell apoptosis and permeability.
    1 context sentence
    Summary · context
    We established a mouse model of high-altitude BRB injury using a simulated high-altitude environment chamber.
  3. 03LabIn vitro (cells)Efficacy outcome

    In hypoxic HUVECs, NMN reduced endothelial cell apoptosis.

    In plain wordsIn cells under low oxygen, NMN reduced programmed endothelial cell death.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseEndothelial apoptosis
    Study

    humann: not reported in source

    Hypoxic HUVECs
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both in vitro and in vivo experiments showed that NMN intervention reduced endothelial cell apoptosis and permeability.
    1 context sentence
    Summary · context
    Human umbilical vein endothelial cells (HUVECs) were cultured in a hypoxic chamber, and the permeability of a confluent monolayer to FITC-dextran was monitored.
  4. 04LabIn vitro (cells)Efficacy outcome

    In hypoxic HUVECs, NMN reduced endothelial permeability.

    In plain wordsIn cells under low oxygen, NMN reduced endothelial permeability.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseEndothelial permeability
    Study

    humann: not reported in source

    Hypoxic HUVECs
    Outcome group
    Vascular function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both in vitro and in vivo experiments showed that NMN intervention reduced endothelial cell apoptosis and permeability.
    1 context sentence
    Summary · context
    Human umbilical vein endothelial cells (HUVECs) were cultured in a hypoxic chamber, and the permeability of a confluent monolayer to FITC-dextran was monitored.
  5. 05LabIn vitro (cells)Mechanism

    In endothelial cells, NMN regulated ROS levels while protecting the endothelial barrier.

    In plain wordsIn cells, NMN regulated reactive oxygen species levels while protecting the endothelial barrier.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedROS levels
    Study

    humann: not reported in source

    Hypoxic HUVECs
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, NMN protected the endothelial barrier by regulating ROS levels in endothelial cells, inhibiting Src phosphorylation, and downregulating the downstream Pi3k/Akt signaling pathway.
    1 context sentence
    Summary · context
    Human umbilical vein endothelial cells (HUVECs) were cultured in a hypoxic chamber, and the permeability of a confluent monolayer to FITC-dextran was monitored.
  6. 06LabIn vitro (cells)Mechanism

    In endothelial cells, NMN inhibited Src phosphorylation.

    In plain wordsIn cells, NMN reduced Src phosphorylation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSrc phosphorylation
    Study

    humann: not reported in source

    Hypoxic HUVECs
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, NMN protected the endothelial barrier by regulating ROS levels in endothelial cells, inhibiting Src phosphorylation, and downregulating the downstream Pi3k/Akt signaling pathway.
    1 context sentence
    Summary · context
    Human umbilical vein endothelial cells (HUVECs) were cultured in a hypoxic chamber, and the permeability of a confluent monolayer to FITC-dextran was monitored.
  7. 07LabIn vitro (cells)Mechanism

    In endothelial cells, NMN downregulated downstream Pi3k/Akt signaling.

    In plain wordsIn cells, NMN reduced downstream Pi3k/Akt signaling.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasePi3k/Akt signaling
    Study

    humann: not reported in source

    Hypoxic HUVECs
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, NMN protected the endothelial barrier by regulating ROS levels in endothelial cells, inhibiting Src phosphorylation, and downregulating the downstream Pi3k/Akt signaling pathway.
    1 context sentence
    Summary · context
    Human umbilical vein endothelial cells (HUVECs) were cultured in a hypoxic chamber, and the permeability of a confluent monolayer to FITC-dextran was monitored.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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