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Study · Animal study (in vivo) · mouse · 2025

7 results

HNGF6A ameliorates oxidative stress-mediated mitochondrial dysfunction in degenerative meniscus.

Liu R, Du X, Chen Y, Zhu Z, Jiang Z, Zhang C, Jiang D, Zhang Z

Bone & joint research7 Apr 2025Cited by 8 (Europe PMC)

PMID40192588 (opens in a new tab)PMCIDPMC11975064 (opens in a new tab)DOI10.1302/2046-3758.144.bjr-2024-0318.r1 (opens in a new tab)PepBankPUB-40192588
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with destabilization of the medial meniscus, HNGF6A alleviated meniscus degeneration.

    In plain wordsIn mice with meniscus injury, a Humanin analogue (HNGF6A) reduced meniscus damage.

    Peptide
    Humanin
    Outcome
    DecreaseMeniscus degeneration
    Study

    mousen: not reported in source

    C57BL/6 mice with destabilization of the medial meniscus
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNGF6A alleviates meniscus degeneration and osteophyte volume
    1 context sentence
    Summary · context
    C57BL/6 mice subjected to destabilization of the medial meniscus (DMM) were either administered or not administered HNGF6A, and gait analysis was performed at eight weeks after surgery.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with destabilization of the medial meniscus, HNGF6A reduced osteophyte volume.

    In plain wordsIn mice with meniscus injury, a Humanin analogue (HNGF6A) reduced bone spur volume.

    Peptide
    Humanin
    Outcome
    DecreaseOsteophyte volume
    Study

    mousen: not reported in source

    C57BL/6 mice with destabilization of the medial meniscus
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNGF6A alleviates meniscus degeneration and osteophyte volume
    1 context sentence
    Summary · context
    C57BL/6 mice subjected to destabilization of the medial meniscus (DMM) were either administered or not administered HNGF6A, and gait analysis was performed at eight weeks after surgery.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with destabilization of the medial meniscus, HNGF6A ameliorated the osteoarthritis phenotype.

    In plain wordsIn mice with meniscus injury, a Humanin analogue (HNGF6A) improved signs of osteoarthritis.

    Peptide
    Humanin
    Outcome
    DecreaseOA phenotype
    Study

    mousen: not reported in source

    C57BL/6 mice with destabilization of the medial meniscus
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ameliorates the OA phenotype in vivo.
    1 context sentence
    Summary · context
    C57BL/6 mice subjected to destabilization of the medial meniscus (DMM) were either administered or not administered HNGF6A, and gait analysis was performed at eight weeks after surgery.
  4. 04LabIn vitro (cells)Efficacy outcome

    In human meniscus cells under oxidative stress, HNGF6A pretreatment restored matrix degradation induced by TBHP.

    In plain wordsIn cells, pretreatment with a Humanin analogue (HNGF6A) reduced matrix damage caused by oxidative stress.

    Peptide
    Humanin
    Outcome
    DecreaseMatrix degradation
    Study

    humann: not reported in source

    primary human meniscus cells with TBHP oxidative stress
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with HNGF6A significantly restored the matrix degradation and cell apoptosis induced by TBHP
    1 context sentence
    Summary · context
    Primary human meniscus cells were subjected to oxidative stress using tert-butyl hydrogen peroxide (TBHP).
  5. 05LabIn vitro (cells)Efficacy outcome

    In human meniscus cells under oxidative stress, HNGF6A pretreatment restored cell apoptosis induced by TBHP.

    In plain wordsIn cells, pretreatment with a Humanin analogue (HNGF6A) reduced cell death caused by oxidative stress.

    Peptide
    Humanin
    Outcome
    DecreaseCell apoptosis
    Study

    humann: not reported in source

    primary human meniscus cells with TBHP oxidative stress
    Outcome group
    Organ injury · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with HNGF6A significantly restored the matrix degradation and cell apoptosis induced by TBHP
    1 context sentence
    Summary · context
    Primary human meniscus cells were subjected to oxidative stress using tert-butyl hydrogen peroxide (TBHP).
  6. 06LabIn vitro (cells)Mechanism

    In human meniscus cells under oxidative stress, HNGF6A pretreatment maintained mitochondrial redox homeostasis.

    In plain wordsIn cells, a Humanin analogue (HNGF6A) helped keep mitochondrial redox balance during oxidative stress.

    Peptide
    Humanin
    Outcome
    Not applicableMitochondrial redox homeostasis
    Study

    humann: not reported in source

    primary human meniscus cells with TBHP oxidative stress
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    maintained mitochondrial redox homeostasis, which corresponded with the activation of autophagy and FUN14 domain containing 1 (FUNDC1) upon HNGF6A treatment
    1 context sentence
    Summary · context
    Primary human meniscus cells were subjected to oxidative stress using tert-butyl hydrogen peroxide (TBHP).
  7. 07LabIn vitro (cells)Mechanism

    In human meniscus cells under oxidative stress, HNGF6A treatment corresponded with activation of autophagy and FUNDC1.

    In plain wordsIn cells, a Humanin analogue (HNGF6A) was linked to switching on autophagy and the FUNDC1 protein.

    Peptide
    Humanin
    Outcome
    IncreaseAutophagy and FUNDC1 activation
    Study

    humann: not reported in source

    primary human meniscus cells with TBHP oxidative stress
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    which corresponded with the activation of autophagy and FUN14 domain containing 1 (FUNDC1) upon HNGF6A treatment.
    1 context sentence
    Summary · context
    Primary human meniscus cells were subjected to oxidative stress using tert-butyl hydrogen peroxide (TBHP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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