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Study · Animal study (in vivo) · rat · 2025

2 results

From the pancreas to the amygdala: New brain area critical for ingestive and motivated behavior control exerted by amylin.

Byun S, Maric I, Börchers S, Sotzen MR, Olekanma D, Hayes MR, Skibicka KP

iScience17 Feb 2025Cited by 10 (Europe PMC)

PMID40124523 (opens in a new tab)PMCIDPMC11928841 (opens in a new tab)DOI10.1016/j.isci.2025.112040 (opens in a new tab)PepBankPUB-40124523
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, pramlintide reduced meal size through action on the central amygdala.

    In plain wordsIn rats, pramlintide reduced meal size through action on the central amygdala.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseMeal size
    Study

    ratsn: not reported in source

    Male and female rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Clinically used amylin analogue, pramlintide, reduced meal size and frequency by acting on the CeA.
    1 context sentence
    Summary · context
    Activation of CeA amylin receptors resulted in a robust hypophagia, reduced food-motivated behavior, and altered macronutrient preference in male and female rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, pramlintide reduced meal frequency through action on the central amygdala.

    In plain wordsIn rats, pramlintide reduced meal frequency through action on the central amygdala.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseMeal frequency
    Study

    ratsn: not reported in source

    Male and female rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Clinically used amylin analogue, pramlintide, reduced meal size and frequency by acting on the CeA.
    1 context sentence
    Summary · context
    Activation of CeA amylin receptors resulted in a robust hypophagia, reduced food-motivated behavior, and altered macronutrient preference in male and female rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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