In mouse embryos with disrupted mitochondrial activity, pooled mitochondrially-targeted agents (BGP-15, MitoQ, SS‑31, metformin) restored deficiencies in neonatal telomere length.
In plain wordsIn mice, a group of mitochondria-targeted agents that included SS‑31 restored shorter newborn telomere length.
- Peptide
- Elamipretide (SS-31)
- Outcome
- IncreaseNeonatal telomere length restoration
- Study
mousen: not reported in source
mouse zygotes and preimplantation embryos- Outcome group
- Aging markers · Aging and longevity
Source sentences
Using mitochondrially-targeted therapeutics (BGP-15, MitoQ, SS-31, metformin) we demonstrate that it is possible to modulate the preimplantation telomere resetting process and restore deficiencies in neonatal telomere length.
1 context sentence(design, population, supporting numbers)
We now show that when mitochondrial activity is disrupted in mouse zygotes, via exposure to 20% O2 or rotenone, telomere elongation between the 8-cell and blastocyst stage is impaired, with shorter telomeres apparent in the pluripotent Inner Cell Mass (ICM) and persisting after organogenesis.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).