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Study · Animal study (in vivo) · rat · 2025

6 results

Influence of carnosine supplementation on disease progression in a rat model of focal segmental glomerulosclerosis.

Xu X, Pastene DO, Qiu J, Schnell B, Maihöfer T, Hettler S, Krämer BK, Hoffmann S, Yard BA

American journal of physiology. Renal physiology13 Mar 2025Cited by 2 (Europe PMC)

PMID40079823 (opens in a new tab)DOI10.1152/ajprenal.00017.2024 (opens in a new tab)PepBankPUB-40079823
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male TGRNeph-hAT1 rats, carnosine ameliorated glomerular hypertrophy.

    In plain wordsIn rats, carnosine reduced enlargement of kidney glomeruli.

    Peptide
    L-carnosine
    Outcome
    DecreaseGlomerular hypertrophy
    Study

    ratn: not reported in source

    Male TGRNeph-hAT1 rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · drinking water · 20 wkAs given in this study (rat).

    Source sentences

    Summary
    Carnosine supplementation ameliorated the glomerular hypertrophy but did not affect albuminuria, renal fibrosis, and podocyte loss.
    1 context sentence
    Summary · context
    Next, male TGRNeph-hAT1 rats were supplemented with carnosine in drinking water for 20 wk.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male TGRNeph-hAT1 rats, carnosine did not affect albuminuria.

    In plain wordsIn rats, carnosine did not change urinary albumin loss.

    Peptide
    L-carnosine
    Outcome
    No significant changeAlbuminuria
    Study

    ratn: not reported in source

    Male TGRNeph-hAT1 rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · drinking water · 20 wkAs given in this study (rat).

    Source sentences

    Summary
    Carnosine supplementation ameliorated the glomerular hypertrophy but did not affect albuminuria, renal fibrosis, and podocyte loss.
    1 context sentence
    Summary · context
    Next, male TGRNeph-hAT1 rats were supplemented with carnosine in drinking water for 20 wk.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male TGRNeph-hAT1 rats, carnosine did not affect renal fibrosis.

    In plain wordsIn rats, carnosine did not change kidney fibrosis.

    Peptide
    L-carnosine
    Outcome
    No significant changeRenal fibrosis
    Study

    ratn: not reported in source

    Male TGRNeph-hAT1 rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · drinking water · 20 wkAs given in this study (rat).

    Source sentences

    Summary
    Carnosine supplementation ameliorated the glomerular hypertrophy but did not affect albuminuria, renal fibrosis, and podocyte loss.
    1 context sentence
    Summary · context
    Next, male TGRNeph-hAT1 rats were supplemented with carnosine in drinking water for 20 wk.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male TGRNeph-hAT1 rats, carnosine did not affect podocyte loss.

    In plain wordsIn rats, carnosine did not change podocyte loss.

    Peptide
    L-carnosine
    Outcome
    No significant changePodocyte loss
    Study

    ratn: not reported in source

    Male TGRNeph-hAT1 rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · drinking water · 20 wkAs given in this study (rat).

    Source sentences

    Summary
    Carnosine supplementation ameliorated the glomerular hypertrophy but did not affect albuminuria, renal fibrosis, and podocyte loss.
    1 context sentence
    Summary · context
    Next, male TGRNeph-hAT1 rats were supplemented with carnosine in drinking water for 20 wk.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In male TGRNeph-hAT1 rats, carnosine significantly reduced renal renin expression.

    In plain wordsIn rats, carnosine reduced renin expression in the kidney.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal renin expression
    Study

    ratn: not reported in source

    Male TGRNeph-hAT1 rats
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated · drinking water · 20 wkAs given in this study (rat).

    Source sentences

    Summary
    Moreover, carnosine significantly reduced renin and increased angiotensin-converting enzyme 2 expression within the kidney.
    1 context sentence
    Summary · context
    Next, male TGRNeph-hAT1 rats were supplemented with carnosine in drinking water for 20 wk.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In male TGRNeph-hAT1 rats, carnosine increased renal angiotensin-converting enzyme 2 expression.

    In plain wordsIn rats, carnosine increased angiotensin-converting enzyme 2 expression in the kidney.

    Peptide
    L-carnosine
    Outcome
    IncreaseRenal ACE2 expression
    Study

    ratn: not reported in source

    Male TGRNeph-hAT1 rats
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated · drinking water · 20 wkAs given in this study (rat).

    Source sentences

    Summary
    Moreover, carnosine significantly reduced renin and increased angiotensin-converting enzyme 2 expression within the kidney.
    1 context sentence
    Summary · context
    Next, male TGRNeph-hAT1 rats were supplemented with carnosine in drinking water for 20 wk.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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