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Study · Animal study (in vivo) · mouse · 2025

12 results

Nicotinamide mononucleotide supplementation ameliorates testicular damage induced by ischemia-reperfusion through reshaping macrophage and neutrophil inflammatory properties.

Mou H, Zhang X, Ren F, Deng Y, Chi A, Zhan G, Li D, Sun Q, You W, Ge Y, Zhang M, Ju Z

International immunopharmacology11 Mar 2025Cited by 5 (Europe PMC)

PMID40073809 (opens in a new tab)DOI10.1016/j.intimp.2025.114407 (opens in a new tab)PepBankPUB-40073809
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with testicular ischemia-reperfusion injury, NMN could increase testicular NAD+ content versus saline.

    In plain wordsIn mice with testicular injury, NMN could increase testicular NAD+ versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseTesticular NAD+
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation could increase testicular NAD+ content, increase serum testosterone levels, prevent Leydig cell and germ cell injury, and improve sperm quantity.
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with testicular ischemia-reperfusion injury, NMN could increase serum testosterone versus saline.

    In plain wordsIn mice with testicular injury, NMN could increase blood testosterone versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSerum testosterone
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation could increase testicular NAD+ content, increase serum testosterone levels, prevent Leydig cell and germ cell injury, and improve sperm quantity.
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with testicular ischemia-reperfusion injury, NMN could prevent Leydig cell injury versus saline.

    In plain wordsIn mice with testicular injury, NMN could prevent Leydig cell damage versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLeydig cell injury
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation could increase testicular NAD+ content, increase serum testosterone levels, prevent Leydig cell and germ cell injury, and improve sperm quantity.
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with testicular ischemia-reperfusion injury, NMN could prevent germ cell injury versus saline.

    In plain wordsIn mice with testicular injury, NMN could prevent germ cell damage versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseGerm cell injury
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation could increase testicular NAD+ content, increase serum testosterone levels, prevent Leydig cell and germ cell injury, and improve sperm quantity.
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with testicular ischemia-reperfusion injury, NMN could improve sperm quantity versus saline.

    In plain wordsIn mice with testicular injury, NMN could improve sperm quantity versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSperm quantity
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation could increase testicular NAD+ content, increase serum testosterone levels, prevent Leydig cell and germ cell injury, and improve sperm quantity.
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with testicular ischemia-reperfusion injury, NMN could mitigate oxidative stress versus saline.

    In plain wordsIn mice with testicular injury, NMN could reduce oxidative stress versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOxidative stress
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, NMN supplementation could mitigate the oxidative stress and cell apoptosis in the I/R injured testes, downregulate the protein expression of p-p65 and p-STAT3 in inflammatory pathways
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with testicular ischemia-reperfusion injury, NMN could mitigate cell apoptosis versus saline.

    In plain wordsIn mice with testicular injury, NMN could reduce programmed cell death versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseCell apoptosis
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, NMN supplementation could mitigate the oxidative stress and cell apoptosis in the I/R injured testes, downregulate the protein expression of p-p65 and p-STAT3 in inflammatory pathways
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with testicular ischemia-reperfusion injury, NMN could downregulate p-p65 protein expression versus saline.

    In plain wordsIn mice with testicular injury, NMN could reduce p-p65 protein expression versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Decreasep-p65 protein
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, NMN supplementation could mitigate the oxidative stress and cell apoptosis in the I/R injured testes, downregulate the protein expression of p-p65 and p-STAT3 in inflammatory pathways
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with testicular ischemia-reperfusion injury, NMN could downregulate p-STAT3 protein expression versus saline.

    In plain wordsIn mice with testicular injury, NMN could reduce p-STAT3 protein expression versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Decreasep-STAT3 protein
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, NMN supplementation could mitigate the oxidative stress and cell apoptosis in the I/R injured testes, downregulate the protein expression of p-p65 and p-STAT3 in inflammatory pathways
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice with testicular ischemia-reperfusion injury, NMN could limit excessive inflammatory responses versus saline.

    In plain wordsIn mice with testicular injury, NMN could reduce excessive inflammation versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseInflammatory responses
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    limit the excessive activation of inflammatory responses in testicular tissues, and reshape the inflammatory properties of macrophages and neutrophils.
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice with testicular ischemia-reperfusion injury, NMN could reshape macrophage inflammatory properties versus saline.

    In plain wordsIn mice with testicular injury, NMN could change macrophage inflammatory properties versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    MixedMacrophage inflammatory properties
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Immune response · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    limit the excessive activation of inflammatory responses in testicular tissues, and reshape the inflammatory properties of macrophages and neutrophils.
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice with testicular ischemia-reperfusion injury, NMN could reshape neutrophil inflammatory properties versus saline.

    In plain wordsIn mice with testicular injury, NMN could change neutrophil inflammatory properties versus saline.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    MixedNeutrophil inflammatory properties
    Study

    mousen: not reported in source

    Testicular torsion-detorsion ischemia-reperfusion injury
    Comparator
    I/R plus saline
    Outcome group
    Immune response · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    limit the excessive activation of inflammatory responses in testicular tissues, and reshape the inflammatory properties of macrophages and neutrophils.
    2 context sentences
    Summary · context
    In this study, we analyzed the therapeutic potentials of NMN supplementation in testicular injury induced by torsion-detorsion in mice.
    Summary · context
    The levels of NAD+ related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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