New Insights in Bovine Follicular Cysts.

Carbonari A, Martino NA, Burgio M, Cicirelli V, Frattina L, Dell'Aquila ME, Rizzo A

Reproduction in domestic animals = Zuchthygiene1 Mar 2025Cited by 3 (Europe PMC)

PMID40056005PMCIDPMC11889522DOI10.1111/rda.70048PepBankPUB-40056005

Summary

The aim of the present study was to understand the involved factors in follicular cysts in dairy cows. The study consisted of an in vivo and in vitro approach. The in vivo part, hormonal evaluation (Kisspeptin-10 [Kp-10], Gonadotropin inhibiting hormone [GnIH], Luteinizing hormone [LH], Oestrogens [E₂] and cortisol) was performed in sera of both healthy (H) and cows with follicular cysts (FC). The in vitro part was concentrated on estimating the distribution of GPR54 (Kp-10 receptor) and GPR147 (GnIH receptor) on cystic and preovulatory follicles. Serum concentrations of Kp-10, GnIH, LH, E₂ and cortisol were significantly higher in Group FC compared with Group H. Gene expression analysis showed a reduction in GPR54 mRNA levels in FC compared to preovulatory follicles, while no expression of the GPR147 receptor was detected. The lower presence of GPR54 in FC compared to the preovulatory follicle can be determined by a down-receptor regulation induced by elevated serum concentrations of Kp-10 in cows with ovarian FC. Endocrine imbalances of the hypothalamic-pituitary-ovarian axis, characterising FC, may reflect altered patterns of Kp-10 and GnIH secretion.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
Serum concentrations of the body's own Kp-10 were significantly higher in dairy cows with follicular cysts than in healthy cows.
In plain wordsIn dairy cows with ovarian cysts, the body's own Kp-10 levels in blood were higher than in healthy cows.
Peptide
Kisspeptin-10
Outcome
IncreaseSerum Kp-10 concentration
Study
cown: not reported in source
Dairy cows with follicular cysts versus healthy cows
Comparator
Healthy cows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Serum concentrations of Kp-10, GnIH, LH, E₂ and cortisol were significantly higher in Group FC compared with Group H.
1 context sentence(design, population, supporting numbers)
Summary · context
The in vivo part, hormonal evaluation (Kisspeptin-10 [Kp-10], Gonadotropin inhibiting hormone [GnIH], Luteinizing hormone [LH], Oestrogens [E₂] and cortisol) was performed in sera of both healthy (H) and cows with follicular cysts (FC).
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4005600501

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

02LabNot a test of Kisspeptin-10 aloneEx vivo tissueOther
GPR54, the Kp-10 receptor, had lower mRNA levels in cystic follicles than in preovulatory follicles of cows.
In plain wordsIn cow ovaries, cystic follicles had less of the receptor for the body's own Kp-10 than normal follicles.
Peptide
Kisspeptin-10
Outcome
DecreaseGPR54 (Kp-10 receptor) mRNA in follicles
Study
cown: not reported in source
Cystic versus preovulatory follicles
Comparator
Preovulatory follicles
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Gene expression analysis showed a reduction in GPR54 mRNA levels in FC compared to preovulatory follicles, while no expression of the GPR147 receptor was detected.
2 context sentences(design, population, supporting numbers)
Summary · context
The in vitro part was concentrated on estimating the distribution of GPR54 (Kp-10 receptor) and GPR147 (GnIH receptor) on cystic and preovulatory follicles.
Summary · context
The in vivo part, hormonal evaluation (Kisspeptin-10 [Kp-10], Gonadotropin inhibiting hormone [GnIH], Luteinizing hormone [LH], Oestrogens [E₂] and cortisol) was performed in sera of both healthy (H) and cows with follicular cysts (FC).
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Show in the study text Report a problemFND-4005600502

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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