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Study · Observational study · n = 2,018 · 2025

7 results

Effects of semaglutide in patients with chronic ankle instability: evidence from a prospective cohort.

Zhang J, Wang C, Wang J, Gu W, Wang H, Zhu H, Ma X, Shi Z

Journal of orthopaedic surgery and research6 Mar 2025Cited by 1 (Europe PMC)

PMID40050929 (opens in a new tab)PMCIDPMC11884071 (opens in a new tab)DOI10.1186/s13018-025-05664-9 (opens in a new tab)PepBankPUB-40050929
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In adults with chronic ankle instability, semaglutide was linked to a larger improvement in the FAAM sports subscale than in controls (adjusted mean difference 16.3).

    In plain wordsIn adults with chronic ankle instability, people who took semaglutide improved more on a sports ability score than people who did not.

    Peptide
    Semaglutide
    Outcome
    IncreaseFAAM sports subscale change from baseline
    Study

    n = 2,018

    Comparator
    Control group without semaglutide
    Analysis
    Primary
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Adjusted mean difference in change, FAAM sports subscale
    16.3 points
    semaglutide vs control

    Source sentences

    Summary
    After controlling baseline characteristics, the adjusted mean difference in change from baseline was 16.3 for FAAM sports subscale and 9.3 for FAAM ADL subscale.
    3 context sentences
    Summary · context
    The primary endpoint was the change from baseline of the Foot and Ankle Ability Measure (FAAM) sports subscale at the last follow up.
    Summary · context
    In this observational study, we recruited more than 2000 adults with CAI according to the selection criteria proposed by International Ankle Consortium with at least two-year follow up from three medical centers.
    Summary · context
    In this study, 71 out of 2018 patients who received semaglutide in purpose of treating type 2 diabetes (T2DM) and/or weight loss during the study period.
  2. 02HumanObservational studyEfficacy outcome

    In adults with chronic ankle instability, semaglutide was linked to a larger improvement in the FAAM ADL subscale than in controls (adjusted mean difference 9.3).

    In plain wordsIn adults with chronic ankle instability, people who took semaglutide improved more on a daily activity score than people who did not.

    Peptide
    Semaglutide
    Outcome
    IncreaseFAAM activities of daily living subscale change from baseline
    Study

    n = 2,018

    Comparator
    Control group without semaglutide
    Analysis
    Secondary
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Adjusted mean difference in change, FAAM ADL subscale
    9.3 points
    semaglutide vs control

    Source sentences

    Summary
    After controlling baseline characteristics, the adjusted mean difference in change from baseline was 16.3 for FAAM sports subscale and 9.3 for FAAM ADL subscale.
    2 context sentences
    Summary · context
    In this observational study, we recruited more than 2000 adults with CAI according to the selection criteria proposed by International Ankle Consortium with at least two-year follow up from three medical centers.
    Summary · context
    In this study, 71 out of 2018 patients who received semaglutide in purpose of treating type 2 diabetes (T2DM) and/or weight loss during the study period.
  3. 03HumanObservational studyEfficacy outcome

    In adults with chronic ankle instability, the adjusted analysis of five FAOS subscales consistently favored the semaglutide group over controls.

    In plain wordsIn adults with chronic ankle instability, five ankle outcome scores all favored people who took semaglutide over people who did not.

    Peptide
    Semaglutide
    Outcome
    IncreaseFAOS subscales
    Study

    n = 2,018

    Comparator
    Control group without semaglutide
    Analysis
    Secondary
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Likewise, the adjusted analysis of five subscales of FAOS showed similar results, all consistently favoring semaglutide group.
    2 context sentences
    Summary · context
    In this observational study, we recruited more than 2000 adults with CAI according to the selection criteria proposed by International Ankle Consortium with at least two-year follow up from three medical centers.
    Summary · context
    In this study, 71 out of 2018 patients who received semaglutide in purpose of treating type 2 diabetes (T2DM) and/or weight loss during the study period.
  4. 04HumanObservational studyEfficacy outcome

    In adults with chronic ankle instability, the semaglutide group had a statistically significant improvement in the CAIT score compared with controls.

    In plain wordsIn adults with chronic ankle instability, people who took semaglutide had a clearly better ankle instability score than people who did not.

    Peptide
    Semaglutide
    Outcome
    IncreaseCAIT score
    Study

    n = 2,018

    Comparator
    Control group without semaglutide
    Analysis
    Secondary
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    For CAIT, patients in the semaglutide group had achieved statistically significant improvement compared with control group.
    2 context sentences
    Summary · context
    In this observational study, we recruited more than 2000 adults with CAI according to the selection criteria proposed by International Ankle Consortium with at least two-year follow up from three medical centers.
    Summary · context
    In this study, 71 out of 2018 patients who received semaglutide in purpose of treating type 2 diabetes (T2DM) and/or weight loss during the study period.
  5. 05HumanObservational studyEfficacy outcome

    In adults with chronic ankle instability, the semaglutide group had a statistically significant decrease in recurrent ankle sprains compared with controls.

    In plain wordsIn adults with chronic ankle instability, people who took semaglutide had clearly fewer repeat ankle sprains than people who did not.

    Peptide
    Semaglutide
    Outcome
    DecreaseRecurrent ankle sprains
    Study

    n = 2,018

    Comparator
    Control group without semaglutide
    Analysis
    Secondary
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also observed statistically significant decreases in number of recurrent ankle sprains during study period.
    2 context sentences
    Summary · context
    In this observational study, we recruited more than 2000 adults with CAI according to the selection criteria proposed by International Ankle Consortium with at least two-year follow up from three medical centers.
    Summary · context
    In this study, 71 out of 2018 patients who received semaglutide in purpose of treating type 2 diabetes (T2DM) and/or weight loss during the study period.
  6. 06HumanObservational studyEfficacy outcome

    In adults with chronic ankle instability, ankle surgery was less frequent with semaglutide (1.4%) than in controls (7.8%).

    In plain wordsIn adults with chronic ankle instability, fewer people who took semaglutide had ankle surgery than people who did not.

    Peptide
    Semaglutide
    Outcome
    DecreaseIncident ankle surgery
    Study

    n = 2,018

    Comparator
    Control group without semaglutide
    Analysis
    Secondary
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Ankle surgery
    1.4%
    semaglutide, 1 of 71
    Ankle surgery
    7.8%
    control, 151 of 1947

    Source sentences

    Summary
    For incident ankle surgery, 1 out of 71 patients (1.4%) and 151 out of 1947 patients (7.8%) received ankle surgeries in semaglutide and control groups, respectively (P = 0.047).
    2 context sentences
    Summary · context
    In this observational study, we recruited more than 2000 adults with CAI according to the selection criteria proposed by International Ankle Consortium with at least two-year follow up from three medical centers.
    Summary · context
    In this study, 71 out of 2018 patients who received semaglutide in purpose of treating type 2 diabetes (T2DM) and/or weight loss during the study period.
  7. 07HumanObservational studyMechanism

    In adults with chronic ankle instability, weight loss measured by BMI mediated about a third of the link between semaglutide and FAAM improvement.

    In plain wordsIn adults with chronic ankle instability, about a third of the better ankle scores in people who took semaglutide was linked to weight loss.

    Peptide
    Semaglutide
    Outcome
    Not applicableMediation of FAAM improvement by BMI weight loss
    Study

    n = 2,018

    Comparator
    Control group without semaglutide
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Mediation proportion, FAAM sports subscale
    31.2%
    semaglutide
    Mediation proportion, ADL subscale
    34.1%
    semaglutide

    Source sentences

    Summary
    The association of semaglutide exposure with improvement in FAAM sports and ADL subscales was mediated by the weight loss measured by BMI (mediation proportion: FAAM sports subscale, 31.2% [22.2-41.2%]; FHSQ ADL subscale, 34.1% [24.4-44.8%]).
    2 context sentences
    Summary · context
    In this observational study, we recruited more than 2000 adults with CAI according to the selection criteria proposed by International Ankle Consortium with at least two-year follow up from three medical centers.
    Summary · context
    In this study, 71 out of 2018 patients who received semaglutide in purpose of treating type 2 diabetes (T2DM) and/or weight loss during the study period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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