Skip to content

Study · Animal study (in vivo) · wistar albino rats (male) · 2025

4 results

Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Experimental Lower-Extremity Ischemia-Reperfusion Injury.

Demirtaş H, Özer A, Yıldırım AK, Dursun AD, Sezen ŞC, Arslan M

Medicina (Kaunas, Lithuania)8 Feb 2025Cited by 16 (Europe PMC)

PMID40005408 (opens in a new tab)PMCIDPMC11857380 (opens in a new tab)DOI10.3390/medicina61020291 (opens in a new tab)PepBankPUB-40005408
Download PDFPubMedAsk about this study
Jump to 4 results

Summary

Background and Objectives: Ischemia-reperfusion (I/R) injury can affect multiple distant organs following I/R in the lower extremities. BPC-157's anti-inflammatory and free radical-neutralizing properties suggest its potential in mitigating ischemia-reperfusion damage. This study evaluates the protective effects of BPC-157 on remote organ damage, including the kidneys, liver, and lungs, in a rat model of skeletal muscle I/R injury. Materials and Methods: A total of 24 male Wistar albino rats were randomly divided into four groups: sham (S), BPC-157(B), lower extremity I/R(IR) and lower extremity I/R+BPC-157(I/RB). Some 45 min of ischemia of lower extremity was followed by 2 h of reperfusion of limbs. BPC-157 was applied to groups B and I/RB at the beginning of the procedure. After 2 h of reperfusion, liver, kidney and lung tissues were harvested for biochemical and histopathological analyses. Results: In the histopathological examination, vascular and glomerular vacuolization, tubular dilation, hyaline casts, and tubular cell shedding in renal tissue were significantly lower in the I/RB group compared to other groups. Lung tissue showed reduced interstitial edema, alveolar congestion, and total damage scores in the I/RB group. Similarly, in liver tissue, sinusoidal dilation, necrotic cells, and mononuclear cell infiltration were significantly lower in the I/RB group. Additionally, the evaluation of TAS, TOS, OSI, and PON-1 revealed a statistically significant increase in antioxidant activity in the liver, lung, and kidney tissues of the I/RB group. Conclusions: The findings of this study demonstrate that BPC-157 exerts a significant protective effect against distant organ damage in the liver, kidneys, and lungs following lower extremity ischemia-reperfusion injury in rats.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats with lower-extremity ischemia-reperfusion injury, renal histopathological damage (vacuolization, tubular dilation, hyaline casts, tubular cell shedding) was significantly lower in the I/R group given BPC‑157 than in the other groups.

    In plain wordsIn rats with limb injury from blocked and restored blood flow, BPC‑157 led to less kidney damage than in other groups.

    Peptide
    BPC-157
    Outcome
    DecreaseRenal histopathological damage
    Study

    Wistar albino rats (male)n = 24

    Lower-extremity skeletal muscle ischemia-reperfusion injury (45 min ischemia, 2 h reperfusion)
    Comparator
    Other groups (sham, BPC-157 alone, lower-extremity I/R)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · Applied at the beginning of the procedure; tissues harvested after 2 h of reperfusionAs given in this study (Wistar albino rats (male)).

    Source sentences

    Summary
    In the histopathological examination, vascular and glomerular vacuolization, tubular dilation, hyaline casts, and tubular cell shedding in renal tissue were significantly lower in the I/RB group compared to other groups.
    2 context sentences
    Summary · context
    A total of 24 male Wistar albino rats were randomly divided into four groups: sham (S), BPC-157(B), lower extremity I/R(IR) and lower extremity I/R+BPC-157(I/RB).
    Summary · context
    BPC-157 was applied to groups B and I/RB at the beginning of the procedure.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats with lower-extremity ischemia-reperfusion injury, lung tissue of the I/R group given BPC‑157 showed reduced interstitial edema, alveolar congestion and total damage scores.

    In plain wordsIn rats with limb injury from blocked and restored blood flow, BPC‑157 was followed by less lung damage.

    Peptide
    BPC-157
    Outcome
    DecreaseLung histopathological damage
    Study

    Wistar albino rats (male)n = 24

    Lower-extremity skeletal muscle ischemia-reperfusion injury (45 min ischemia, 2 h reperfusion)
    Outcome group
    Organ injury · Respiratory
    Studied dose
    Dose not stated · Applied at the beginning of the procedure; tissues harvested after 2 h of reperfusionAs given in this study (Wistar albino rats (male)).

    Source sentences

    Summary
    Lung tissue showed reduced interstitial edema, alveolar congestion, and total damage scores in the I/RB group.
    2 context sentences
    Summary · context
    A total of 24 male Wistar albino rats were randomly divided into four groups: sham (S), BPC-157(B), lower extremity I/R(IR) and lower extremity I/R+BPC-157(I/RB).
    Summary · context
    BPC-157 was applied to groups B and I/RB at the beginning of the procedure.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats with lower-extremity ischemia-reperfusion injury, sinusoidal dilation, necrotic cells and mononuclear cell infiltration in liver tissue were significantly lower in the I/R group given BPC‑157.

    In plain wordsIn rats with limb injury from blocked and restored blood flow, BPC‑157 was followed by less liver damage.

    Peptide
    BPC-157
    Outcome
    DecreaseLiver histopathological damage
    Study

    Wistar albino rats (male)n = 24

    Lower-extremity skeletal muscle ischemia-reperfusion injury (45 min ischemia, 2 h reperfusion)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · Applied at the beginning of the procedure; tissues harvested after 2 h of reperfusionAs given in this study (Wistar albino rats (male)).

    Source sentences

    Summary
    Similarly, in liver tissue, sinusoidal dilation, necrotic cells, and mononuclear cell infiltration were significantly lower in the I/RB group.
    2 context sentences
    Summary · context
    A total of 24 male Wistar albino rats were randomly divided into four groups: sham (S), BPC-157(B), lower extremity I/R(IR) and lower extremity I/R+BPC-157(I/RB).
    Summary · context
    BPC-157 was applied to groups B and I/RB at the beginning of the procedure.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats with lower-extremity ischemia-reperfusion injury, TAS, TOS, OSI and PON-1 measures showed a statistically significant increase in antioxidant activity in liver, lung and kidney tissue of the I/R group given BPC‑157.

    In plain wordsIn rats with limb injury from blocked and restored blood flow, BPC‑157 was followed by higher antioxidant activity in liver, lung and kidney tissue.

    Peptide
    BPC-157
    Outcome
    IncreaseTissue antioxidant activity (TAS, TOS, OSI, PON-1)
    Study

    Wistar albino rats (male)n = 24

    Lower-extremity skeletal muscle ischemia-reperfusion injury (45 min ischemia, 2 h reperfusion)
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated · Applied at the beginning of the procedure; tissues harvested after 2 h of reperfusionAs given in this study (Wistar albino rats (male)).

    Source sentences

    Summary
    Additionally, the evaluation of TAS, TOS, OSI, and PON-1 revealed a statistically significant increase in antioxidant activity in the liver, lung, and kidney tissues of the I/RB group.
    2 context sentences
    Summary · context
    A total of 24 male Wistar albino rats were randomly divided into four groups: sham (S), BPC-157(B), lower extremity I/R(IR) and lower extremity I/R+BPC-157(I/RB).
    Summary · context
    BPC-157 was applied to groups B and I/RB at the beginning of the procedure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 12:39 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.