Potential Drug Interaction Between Liraglutide and Clonazepam: A Case Report.

Kheradmand A, Mehrvar A, Abbasinazari M

Case reports in psychiatry11 Feb 2025

PMID39974287PMCIDPMC11835470DOI10.1155/crps/9100558PepBankPUB-39974287

Summary

Aviophobia, that is, fear of flying, is a common type of anxiety disorder. Benzodiazepines are used in the treatment of anxiety. Liraglutide is a treatment for obesity or overweight in combination with weight-related comorbidity. We present the case of a 23-year-old woman with overweight and aviophobia, who used clonazepam as antianxious protection when flying. When taking liraglutide shortly before clonazepam the efficacy of clonazepam seemed absent as the patient experienced a panic attack at the airport. This finding suggests that liraglutide may interfere with clonazepam and reduce its effect. Further research is needed to establish this association.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Liraglutide.

01HumanNot a test of Liraglutide aloneCase report or seriesOther
In a woman with overweight and aviophobia, clonazepam efficacy seemed absent after liraglutide was taken shortly before it; no measured efficacy contrast was reported.
In plain wordsIn a woman with overweight and fear of flying, clonazepam seemed ineffective after liraglutide was taken shortly before it.
Peptide
Liraglutide
Outcome
Not applicableClonazepam efficacy
Study
n = 1
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
When taking liraglutide shortly before clonazepam the efficacy of clonazepam seemed absent as the patient experienced a panic attack at the airport.
1 context sentence(design, population, supporting numbers)
Summary · context
We present the case of a 23-year-old woman with overweight and aviophobia, who used clonazepam as antianxious protection when flying.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-3997428701
02HumanNot a test of Liraglutide aloneCase report or seriesSafety outcome
In a woman with overweight and aviophobia, a panic attack occurred at the airport when liraglutide was taken shortly before clonazepam.
In plain wordsIn one woman with overweight and fear of flying, a panic attack occurred after liraglutide was taken shortly before clonazepam.
Peptide
Liraglutide
Outcome
Not applicablePanic attack
Study
n = 1
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
When taking liraglutide shortly before clonazepam the efficacy of clonazepam seemed absent as the patient experienced a panic attack at the airport.
1 context sentence(design, population, supporting numbers)
Summary · context
We present the case of a 23-year-old woman with overweight and aviophobia, who used clonazepam as antianxious protection when flying.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Show in the study text Report a problemFND-3997428702

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 11:11 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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