Exploring the Relationship Between Thymosin β4 Protein and First Myocardial Infarction on the Basis of Proteomics.

Lu Z, Liu Q, Fan Y, Xiao Q, Yin D, Li Y

Journal of the American Heart Association14 Feb 2025Cited by 2 (Europe PMC)

PMID39950438PMCIDPMC12074714DOI10.1161/jaha.124.038177PepBankPUB-39950438

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In adults with first-onset acute myocardial infarction, plasma TMSB4 levels were higher than in healthy controls.
In plain wordsIn people with a first heart attack, the body's own thymosin beta‑4 level in blood was higher than in healthy people.
Peptide
Thymosin beta-4 (human)
Outcome
IncreasePlasma TMSB4 level in first-onset AMI
Study
n = 388
Comparator
Healthy controls
Outcome group
Cardiovascular events · Cardiovascular
Measurements
Plasma TMSB4 median
1093 ng/mL
first-onset AMI
Plasma TMSB4 median
421 ng/mL
controls
Source sentences
Summary
Plasma TMSB4 levels were significantly elevated in patients with first-onset AMI compared with the control group (1093 [701-1608] ng/mL versus 421 [245-658] ng/mL; P<0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
Using a case-control design, we recruited 6 patients with first-onset AMI and 6 age- and sex-matched healthy controls.
Summary · context
Additionally, we enrolled 156 patients with AMI and 232 healthy individuals to validate the differentially expressed proteins using ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3995043801
02HumanEndogenous levelObservational studyOther
Univariate and multivariate logistic regression indicated that TMSB4 is a risk factor for first-onset AMI.
In plain wordsA higher level of the body's own thymosin beta‑4 was linked to a first heart attack.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableTMSB4 as risk factor for first-onset AMI
Study
n: not reported in source
Comparator
Healthy controls
Outcome group
Cardiovascular events · Cardiovascular
Source sentences
Summary
Univariate and multivariate logistic regression analyses indicated that TMSB4 is a risk factor for first-onset AMI.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a case-control design, we recruited 6 patients with first-onset AMI and 6 age- and sex-matched healthy controls.
Summary · context
Additionally, we enrolled 156 patients with AMI and 232 healthy individuals to validate the differentially expressed proteins using ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3995043802
03HumanEndogenous levelObservational studyOther
The receiver operating characteristic curve for plasma TMSB4 gave an area under the curve of 0.849, with a cutoff of 682 ng/mL.
In plain wordsBlood levels of the body's own thymosin beta‑4 separated people with a first heart attack from healthy people fairly well.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableDiagnostic accuracy of TMSB4 for first-onset AMI
Study
n: not reported in source
Comparator
Healthy controls
Outcome group
Cardiovascular events · Cardiovascular
Measurements
AUC
0.849
TMSB4 for AMI
Optimal cutoff
682 ng/mL
TMSB4
Sensitivity
0.808
at cutoff
Specificity
0.793
at cutoff
Source sentences
Summary
The receiver operating characteristic curve yielded an area under the curve value of 0.849, with an optimal cutoff of 682 ng/mL, sensitivity of 0.808, and specificity of 0.793.
2 context sentences(design, population, supporting numbers)
Summary · context
Using a case-control design, we recruited 6 patients with first-onset AMI and 6 age- and sex-matched healthy controls.
Summary · context
Additionally, we enrolled 156 patients with AMI and 232 healthy individuals to validate the differentially expressed proteins using ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3995043803
04HumanEndogenous levelObservational studyOther
Plasma TMSB4 correlated closely with cardiac troponin I, and the kappa test gave moderate concordance.
In plain wordsThe body's own thymosin beta‑4 level in blood was closely linked to troponin I, a heart injury marker.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableTMSB4 correlation with cardiac troponin I
Study
n: not reported in source
Comparator
Cardiac troponin I
Outcome group
Cardiovascular events · Cardiovascular
Measurements
Correlation r
0.9044
TMSB4 vs troponin I
Kappa
0.59
concordance
Source sentences
Summary
A robust correlation was observed between TMSB4 and cardiac troponin I (r=0.9044, PP<0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
Using a case-control design, we recruited 6 patients with first-onset AMI and 6 age- and sex-matched healthy controls.
Summary · context
Additionally, we enrolled 156 patients with AMI and 232 healthy individuals to validate the differentially expressed proteins using ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3995043804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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