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Study · Not a test of the peptide alone · 2024

6 results

Complex NADASE Infusions Improve Clinical Outcome in Substance Use Disorder: Descriptive Annotation in Fifty Cases.

Blum K, Mclaughlin T, Lewandrowski KU, Sharafshah A, Dennen C, Thanos PK, Baron D, Modestino EJ, Sunder K, Murphy KT, Makle M, Giley E, Braverman ER, Giordano J, Badgaiyan RD

Journal of addiction psychiatry1 Aug 2024Cited by 1 (Europe PMC)

PMID39949994 (opens in a new tab)PMCIDPMC11823434 (opens in a new tab)DOI10.17756/jap.2024-046 (opens in a new tab)PepBankPUB-39949994
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Summary

BackgroundThe present study relates to a method to treat and detoxify patients with substance use disorder (SUD) utilizing a series of nicotinamide adenine dinucleotide (NAD+) and enkephalinase infusions (NADASE) in subjects attending chemical dependency programs.ObjectiveThe primary objective of the current investigation is to provide some additional clinical evidence to show that NAD+ other amino acids including d-phenylalanine, glycine and ananylglutamine dipeptide and Myer's cocktail (B complex) infusions significantly attenuates substance craving behavior and concomitant psychiatric burden sequalae in poly-drug abusers attending both in-patient and out-patient level of care in a number of chemical dependency programs in orange country.MethodsAt symmetry approximately 1,000 now performed approximately 1,000 infusions on 900 patients without any serious side effects pointing to the safety of this procedure. The study cohort (n = 50) as a subgroup consisted of highly addicted poly-drug mixed gender and varied ethnic individuals previously resistant to standard treatment with a range of failed treatment attempts from one to ten. Each patient included in this study received a minimum of 7 infusions for an average duration of four weeks. The data includes craving scores, anxiety, depression, and sleep. We utilized likert scales (1 - 10) self-reported responses, accomplished via a counselor to patient structured interview.ResultsIn summary considering all fifty subjects using wilcoxon signed rank tests and sign tests, we found the following significance comparing the baseline scores to post outcome scores after NAD infusions; craving scores (P = 1.063E-9); anxiety (P = 5.487E-7); and depression (P = 1.763E-4). There was an improvement trend in the number of sleep hours post infusions, it was non-significant (Pre 6.28, and post 7.34). Importantly, urine analysis of a standard panel of illicit drugs of abuse during the course of NAD infusions resulted in a subset of 40 patients tested at midway during infusions 100% of these patients tested negative.ConclusionThese annotated notes serve an important function showing patient to patient similarities and differences and contribute to the emerging literature concerning NAD efficacy in SUD.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  1. 01HumanNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneCase report or seriesSafety outcome

    In patients receiving the combined NADASE infusion procedure, the report described no serious side effects in 900 patients.

    In plain wordsIn 900 patients, the combined NADASE infusion procedure had no reported serious side effects.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableSerious side effects
    Study

    n = 900

    Outcome group
    Adverse events · Whole body

    Source sentences

    Summary
    At symmetry approximately 1,000 now performed approximately 1,000 infusions on 900 patients without any serious side effects pointing to the safety of this procedure.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  2. 02HumanNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneCase report or seriesEfficacy outcome

    In patients with substance use disorder, craving scores changed significantly from baseline after combined NADASE infusions.

    In plain wordsIn patients with substance use disorder, craving scores changed significantly after combined NADASE infusions compared with baseline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedCraving score
    Study

    n = 50

    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood

    Source sentences

    Summary
    In summary considering all fifty subjects using wilcoxon signed rank tests and sign tests, we found the following significance comparing the baseline scores to post outcome scores after NAD infusions; craving scores (P = 1.063E-9); anxiety (P = 5.487E-7); and depression (P = 1.763E-4).
    3 context sentences
    Summary · context
    The study cohort (n = 50) as a subgroup consisted of highly addicted poly-drug mixed gender and varied ethnic individuals previously resistant to standard treatment with a range of failed treatment attempts from one to ten.
    Summary · context
    Each patient included in this study received a minimum of 7 infusions for an average duration of four weeks.
    Summary · context
    We utilized likert scales (1 - 10) self-reported responses, accomplished via a counselor to patient structured interview.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  3. 03HumanNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneCase report or seriesEfficacy outcome

    In patients with substance use disorder, anxiety scores changed significantly from baseline after combined NADASE infusions.

    In plain wordsIn patients with substance use disorder, anxiety scores changed significantly after combined NADASE infusions compared with baseline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedAnxiety score
    Study

    n = 50

    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    In summary considering all fifty subjects using wilcoxon signed rank tests and sign tests, we found the following significance comparing the baseline scores to post outcome scores after NAD infusions; craving scores (P = 1.063E-9); anxiety (P = 5.487E-7); and depression (P = 1.763E-4).
    3 context sentences
    Summary · context
    The study cohort (n = 50) as a subgroup consisted of highly addicted poly-drug mixed gender and varied ethnic individuals previously resistant to standard treatment with a range of failed treatment attempts from one to ten.
    Summary · context
    Each patient included in this study received a minimum of 7 infusions for an average duration of four weeks.
    Summary · context
    We utilized likert scales (1 - 10) self-reported responses, accomplished via a counselor to patient structured interview.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  4. 04HumanNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneCase report or seriesEfficacy outcome

    In patients with substance use disorder, depression scores changed significantly from baseline after combined NADASE infusions.

    In plain wordsIn patients with substance use disorder, depression scores changed significantly after combined NADASE infusions compared with baseline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedDepression score
    Study

    n = 50

    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    In summary considering all fifty subjects using wilcoxon signed rank tests and sign tests, we found the following significance comparing the baseline scores to post outcome scores after NAD infusions; craving scores (P = 1.063E-9); anxiety (P = 5.487E-7); and depression (P = 1.763E-4).
    3 context sentences
    Summary · context
    The study cohort (n = 50) as a subgroup consisted of highly addicted poly-drug mixed gender and varied ethnic individuals previously resistant to standard treatment with a range of failed treatment attempts from one to ten.
    Summary · context
    Each patient included in this study received a minimum of 7 infusions for an average duration of four weeks.
    Summary · context
    We utilized likert scales (1 - 10) self-reported responses, accomplished via a counselor to patient structured interview.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  5. 05HumanNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneCase report or seriesEfficacy outcome

    In patients with substance use disorder, sleep hours increased nonsignificantly from baseline after combined NADASE infusions.

    In plain wordsIn patients with substance use disorder, sleep hours did not change significantly after combined NADASE infusions compared with baseline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    No significant changeSleep hours
    Study

    n = 50

    Outcome group
    Sleep · Sleep

    Measurements

    Sleep hours
    6.28 hours
    pre infusion
    Sleep hours
    7.34 hours
    post infusion

    Source sentences

    Summary
    There was an improvement trend in the number of sleep hours post infusions, it was non-significant (Pre 6.28, and post 7.34).
    3 context sentences
    Summary · context
    The study cohort (n = 50) as a subgroup consisted of highly addicted poly-drug mixed gender and varied ethnic individuals previously resistant to standard treatment with a range of failed treatment attempts from one to ten.
    Summary · context
    Each patient included in this study received a minimum of 7 infusions for an average duration of four weeks.
    Summary · context
    We utilized likert scales (1 - 10) self-reported responses, accomplished via a counselor to patient structured interview.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  6. 06HumanNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneCase report or seriesEfficacy outcome

    In the tested substance use disorder subset, 100% had negative illicit-drug urine panels midway through combined NADASE infusions.

    In plain wordsIn 40 tested patients with substance use disorder, 100% had negative illicit-drug urine tests midway through combined NADASE infusions.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableNegative illicit-drug urine tests
    Study

    n = 40

    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood

    Measurements

    Negative urine tests
    100%
    midway infusions

    Source sentences

    Summary
    Importantly, urine analysis of a standard panel of illicit drugs of abuse during the course of NAD infusions resulted in a subset of 40 patients tested at midway during infusions 100% of these patients tested negative.
    3 context sentences
    Summary · context
    The study cohort (n = 50) as a subgroup consisted of highly addicted poly-drug mixed gender and varied ethnic individuals previously resistant to standard treatment with a range of failed treatment attempts from one to ten.
    Summary · context
    Each patient included in this study received a minimum of 7 infusions for an average duration of four weeks.
    Summary · context
    We utilized likert scales (1 - 10) self-reported responses, accomplished via a counselor to patient structured interview.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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