Nicotinamide mononucleotide supplementation improves oocyte developmental competence in different ovarian damage conditions.

Ramírez-Martín N, Buigues A, Rodríguez-Varela C, Martínez J, Blázquez-Simón P, Rodríguez-Hernández C, Pellicer N, Pellicer A, Escribá MJ, Herraiz S

American journal of obstetrics and gynecology7 Feb 2025Cited by 8 (Europe PMC)

PMID39923879DOI10.1016/j.ajog.2025.02.006PepBankPUB-39923879

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study19

19 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diminished ovarian reserve mice, NMN over a complete folliculogenesis cycle improved chemotherapy-exposed oocyte quality.
In plain wordsIn mice with diminished ovarian reserve, NMN improved oocyte quality versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
MixedOocyte quality
Study
mousen: not reported in source
Chemotherapy-induced diminished ovarian reserve
Comparator
Without NMN treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
Nicotinamide mononucleotide supplementation over a complete folliculogenesis cycle (4 weeks) improved the quality of oocytes exposed to chemotherapy by recovering nicotinamide adenine dinucleotide levels (P=.006)
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387901
02AnimalAnimal study (in vivo)Efficacy outcome
In diminished ovarian reserve mice, NMN over a complete folliculogenesis cycle recovered oocyte NAD+ levels.
In plain wordsIn mice with diminished ovarian reserve, NMN restored oocyte NAD+ levels versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOocyte NAD+
Study
mousen: not reported in source
Chemotherapy-induced diminished ovarian reserve
Comparator
Without NMN treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
Nicotinamide mononucleotide supplementation over a complete folliculogenesis cycle (4 weeks) improved the quality of oocytes exposed to chemotherapy by recovering nicotinamide adenine dinucleotide levels (P=.006)
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387902
03AnimalAnimal study (in vivo)Efficacy outcome
In diminished ovarian reserve mice, NMN redistributed oocyte mitochondria to promote proper meiotic spindle assembly.
In plain wordsIn mice with diminished ovarian reserve, NMN redistributed oocyte mitochondria versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
MixedMitochondrial distribution
Study
mousen: not reported in source
Chemotherapy-induced diminished ovarian reserve
Comparator
Without NMN treatment
Outcome group
Mitochondrial function · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
redistributing mitochondria to promote proper meiotic spindle assembly, and ultimately, recovering fertilization rate (P=.003) in diminished ovarian reserve mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387903
04AnimalAnimal study (in vivo)Efficacy outcome
In diminished ovarian reserve mice, NMN promoted proper meiotic spindle assembly through mitochondrial redistribution.
In plain wordsIn mice with diminished ovarian reserve, NMN promoted proper oocyte spindle assembly versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
MixedMeiotic spindle assembly
Study
mousen: not reported in source
Chemotherapy-induced diminished ovarian reserve
Comparator
Without NMN treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
redistributing mitochondria to promote proper meiotic spindle assembly, and ultimately, recovering fertilization rate (P=.003) in diminished ovarian reserve mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387904
05AnimalAnimal study (in vivo)Efficacy outcome
In diminished ovarian reserve mice, NMN recovered fertilization rate.
In plain wordsIn mice with diminished ovarian reserve, NMN restored fertilization rate versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseFertilization rate
Study
mousen: not reported in source
Chemotherapy-induced diminished ovarian reserve
Comparator
Without NMN treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
redistributing mitochondria to promote proper meiotic spindle assembly, and ultimately, recovering fertilization rate (P=.003) in diminished ovarian reserve mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387905
06AnimalAnimal study (in vivo)Efficacy outcome
In premature ovarian insufficiency mice, NMN reduced reactive oxygen species abundance.
In plain wordsIn mice with premature ovarian insufficiency, NMN reduced reactive oxygen species versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseReactive oxygen species
Study
mousen: not reported in source
Chemotherapy-induced premature ovarian insufficiency
Comparator
Without NMN treatment
Outcome group
Mitochondrial function · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
In the premature ovarian insufficiency model, reduced reactive oxygen species abundance (P=.039), increased mitochondria quantity (P=.030), and improved expression of the DNA repair gene apurinic/apyrimidinic endonuclease 1 [Apex1] were found, thereby enhancing proper meiotic spindle formation and chromosome alignment.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387906
07AnimalAnimal study (in vivo)Efficacy outcome
In premature ovarian insufficiency mice, NMN increased mitochondria quantity.
In plain wordsIn mice with premature ovarian insufficiency, NMN increased mitochondria quantity versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMitochondria quantity
Study
mousen: not reported in source
Chemotherapy-induced premature ovarian insufficiency
Comparator
Without NMN treatment
Outcome group
Mitochondrial function · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
In the premature ovarian insufficiency model, reduced reactive oxygen species abundance (P=.039), increased mitochondria quantity (P=.030), and improved expression of the DNA repair gene apurinic/apyrimidinic endonuclease 1 [Apex1] were found, thereby enhancing proper meiotic spindle formation and chromosome alignment.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387907
08AnimalAnimal study (in vivo)Efficacy outcome
In premature ovarian insufficiency mice, NMN improved expression of the DNA repair gene Apex1.
In plain wordsIn mice with premature ovarian insufficiency, NMN improved Apex1 DNA repair gene expression versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseApex1 expression
Study
mousen: not reported in source
Chemotherapy-induced premature ovarian insufficiency
Comparator
Without NMN treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
In the premature ovarian insufficiency model, reduced reactive oxygen species abundance (P=.039), increased mitochondria quantity (P=.030), and improved expression of the DNA repair gene apurinic/apyrimidinic endonuclease 1 [Apex1] were found, thereby enhancing proper meiotic spindle formation and chromosome alignment.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387908
09AnimalAnimal study (in vivo)Efficacy outcome
In premature ovarian insufficiency mice, NMN enhanced proper meiotic spindle formation.
In plain wordsIn mice with premature ovarian insufficiency, NMN improved oocyte spindle formation versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
MixedMeiotic spindle formation
Study
mousen: not reported in source
Chemotherapy-induced premature ovarian insufficiency
Comparator
Without NMN treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
In the premature ovarian insufficiency model, reduced reactive oxygen species abundance (P=.039), increased mitochondria quantity (P=.030), and improved expression of the DNA repair gene apurinic/apyrimidinic endonuclease 1 [Apex1] were found, thereby enhancing proper meiotic spindle formation and chromosome alignment.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387909
10AnimalAnimal study (in vivo)Efficacy outcome
In premature ovarian insufficiency mice, NMN enhanced chromosome alignment.
In plain wordsIn mice with premature ovarian insufficiency, NMN improved chromosome alignment versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
MixedChromosome alignment
Study
mousen: not reported in source
Chemotherapy-induced premature ovarian insufficiency
Comparator
Without NMN treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 4 weeksAs given in this study (mouse).
Source sentences
Summary
In the premature ovarian insufficiency model, reduced reactive oxygen species abundance (P=.039), increased mitochondria quantity (P=.030), and improved expression of the DNA repair gene apurinic/apyrimidinic endonuclease 1 [Apex1] were found, thereby enhancing proper meiotic spindle formation and chromosome alignment.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387910
11AnimalAnimal study (in vivo)Efficacy outcome
In mice, 14-day NMN supplementation improved oocyte quality versus no NMN, with smaller benefits than complete-cycle supplementation.
In plain wordsIn mice, 14-day NMN supplementation improved oocyte quality versus no NMN, with smaller benefits than complete-cycle supplementation.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
MixedOocyte quality
Study
mousen: not reported in source
Chemotherapy-induced ovarian damage
Comparator
Without NMN treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 14 daysAs given in this study (mouse).
Source sentences
Summary
Similarly, when nicotinamide mononucleotide supplementation was restricted to the later stages of folliculogenesis (14 days), positive effects on oocyte quality were observed, though to a lesser extent.
1 context sentence(design, population, supporting numbers)
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387911
12AnimalAnimal study (in vivo)Efficacy outcome
In diminished ovarian reserve mice, NMN during later folliculogenesis increased NAD+ levels.
In plain wordsIn mice with diminished ovarian reserve, later NMN treatment increased NAD+ levels versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOocyte NAD+
Study
mousen: not reported in source
Chemotherapy-induced diminished ovarian reserve
Comparator
Without NMN treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 14 daysAs given in this study (mouse).
Source sentences
Summary
Increased nicotinamide adenine dinucleotide levels (P˂.001) and embryo development rates (P=.048) were found in the diminished ovarian reserve group
2 context sentences(design, population, supporting numbers)
Summary · context
Similarly, when nicotinamide mononucleotide supplementation was restricted to the later stages of folliculogenesis (14 days), positive effects on oocyte quality were observed, though to a lesser extent.
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387912
13AnimalAnimal study (in vivo)Efficacy outcome
In diminished ovarian reserve mice, NMN during later folliculogenesis increased embryo development rates.
In plain wordsIn mice with diminished ovarian reserve, later NMN treatment increased embryo development rates versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseEmbryo development rates
Study
mousen: not reported in source
Chemotherapy-induced diminished ovarian reserve
Comparator
Without NMN treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 14 daysAs given in this study (mouse).
Source sentences
Summary
Increased nicotinamide adenine dinucleotide levels (P˂.001) and embryo development rates (P=.048) were found in the diminished ovarian reserve group
2 context sentences(design, population, supporting numbers)
Summary · context
Similarly, when nicotinamide mononucleotide supplementation was restricted to the later stages of folliculogenesis (14 days), positive effects on oocyte quality were observed, though to a lesser extent.
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387913
14AnimalAnimal study (in vivo)Efficacy outcome
In premature ovarian insufficiency mice, NMN during later folliculogenesis reduced reactive oxygen species abundance.
In plain wordsIn mice with premature ovarian insufficiency, later NMN treatment reduced reactive oxygen species versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseReactive oxygen species
Study
mousen: not reported in source
Chemotherapy-induced premature ovarian insufficiency
Comparator
Without NMN treatment
Outcome group
Mitochondrial function · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 14 daysAs given in this study (mouse).
Source sentences
Summary
while reduced reactive oxygen species abundance (P=.040), and increased mitochondrial DNA copy number (P=.006) and DNA repair gene expression (Apex1: P=.041; AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase (Alkbh2): P=.029) were observed in premature ovarian insufficiency mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Similarly, when nicotinamide mononucleotide supplementation was restricted to the later stages of folliculogenesis (14 days), positive effects on oocyte quality were observed, though to a lesser extent.
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387914
15AnimalAnimal study (in vivo)Efficacy outcome
In premature ovarian insufficiency mice, NMN during later folliculogenesis increased mitochondrial DNA copy number.
In plain wordsIn mice with premature ovarian insufficiency, later NMN treatment increased mitochondrial DNA copy number versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseMitochondrial DNA copy number
Study
mousen: not reported in source
Chemotherapy-induced premature ovarian insufficiency
Comparator
Without NMN treatment
Outcome group
Mitochondrial function · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 14 daysAs given in this study (mouse).
Source sentences
Summary
while reduced reactive oxygen species abundance (P=.040), and increased mitochondrial DNA copy number (P=.006) and DNA repair gene expression (Apex1: P=.041; AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase (Alkbh2): P=.029) were observed in premature ovarian insufficiency mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Similarly, when nicotinamide mononucleotide supplementation was restricted to the later stages of folliculogenesis (14 days), positive effects on oocyte quality were observed, though to a lesser extent.
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387915
16AnimalAnimal study (in vivo)Efficacy outcome
In premature ovarian insufficiency mice, NMN during later folliculogenesis increased Apex1 expression.
In plain wordsIn mice with premature ovarian insufficiency, later NMN treatment increased Apex1 expression versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseApex1 expression
Study
mousen: not reported in source
Chemotherapy-induced premature ovarian insufficiency
Comparator
Without NMN treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 14 daysAs given in this study (mouse).
Source sentences
Summary
while reduced reactive oxygen species abundance (P=.040), and increased mitochondrial DNA copy number (P=.006) and DNA repair gene expression (Apex1: P=.041; AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase (Alkbh2): P=.029) were observed in premature ovarian insufficiency mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Similarly, when nicotinamide mononucleotide supplementation was restricted to the later stages of folliculogenesis (14 days), positive effects on oocyte quality were observed, though to a lesser extent.
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387916
17AnimalAnimal study (in vivo)Efficacy outcome
In premature ovarian insufficiency mice, NMN during later folliculogenesis increased Alkbh2 expression.
In plain wordsIn mice with premature ovarian insufficiency, later NMN treatment increased Alkbh2 expression versus no NMN.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseAlkbh2 expression
Study
mousen: not reported in source
Chemotherapy-induced premature ovarian insufficiency
Comparator
Without NMN treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
2 g/L · drinking water · 14 daysAs given in this study (mouse).
Source sentences
Summary
while reduced reactive oxygen species abundance (P=.040), and increased mitochondrial DNA copy number (P=.006) and DNA repair gene expression (Apex1: P=.041; AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase (Alkbh2): P=.029) were observed in premature ovarian insufficiency mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Similarly, when nicotinamide mononucleotide supplementation was restricted to the later stages of folliculogenesis (14 days), positive effects on oocyte quality were observed, though to a lesser extent.
Summary · context
Mice of each ovarian condition were treated with or without 2 g/L nicotinamide mononucleotide in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis.
Report a problemFND-3992387917
18LabEx vivo tissueEfficacy outcome
In immature oocytes from women with advanced maternal age, in vitro NMN improved nuclear competence.
In plain wordsIn lab tests of isolated immature oocytes, NMN improved nuclear competence.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseNuclear competence
Study
humann: not reported in source
Immature oocytes from women with advanced maternal age
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 µMAs given in this study (human).
Source sentences
Summary
Finally, in vitro supplementation with 100 µM nicotinamide mononucleotide was able to improve the nuclear competence (P=.039) and parthenogenetic activation of immature oocytes from women with advanced maternal age (>38 years old).
Report a problemFND-3992387918
19LabEx vivo tissueEfficacy outcome
In immature oocytes from women with advanced maternal age, in vitro NMN improved parthenogenetic activation.
In plain wordsIn lab tests of isolated immature oocytes, NMN improved activation without fertilization.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseParthenogenetic activation
Study
humann: not reported in source
Immature oocytes from women with advanced maternal age
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 µMAs given in this study (human).
Source sentences
Summary
Finally, in vitro supplementation with 100 µM nicotinamide mononucleotide was able to improve the nuclear competence (P=.039) and parthenogenetic activation of immature oocytes from women with advanced maternal age (>38 years old).
Report a problemFND-3992387919

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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